Protein Alignment Ddr and Ephb3

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_034273.1
• Gene: Ephb3 / 13845
• MGIID: 104770
• Length: 993
• Species: Mus musculus
• Alignment Length: 299
• Identity: 98/299 - (32%)
• Similarity: 161/299 - (53%)
• Gaps: 34/299 - (11%)

  Fly   745 ERANCQVQEFPRQ---SLVIVEK-LGSGVFGELHLCETNV----LNATLVAVATLRPGANDHLRK 801
            |..|..|:||.::   |.|.:|: :|:|.|||  :|...:    .....||:.||:.|..:..|:
Mouse   610 EDPNEAVREFAKEIDVSCVKIEEVIGAGEFGE--VCRGRLKLPGRREVFVAIKTLKVGYTERQRR 672

  Fly   802 EFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDY-SHCLGDLNQFLQEHVAETSGLMAKKSLS 865
            :|.|:|..:.|...||:.||.|...:..|:.|:.:: .:|.  |:.||:.:..:.:.:.
Mouse   673 DFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCA--LDSFLRLNDGQFTVIQ------ 729

  Fly   866 FGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGF 930
               ||.:...||:|||:|.:||:||||||.|:.::...|..||...|.    |.:..|......:
Mouse   730 ---LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGL----SRFLEDDPSDPTY 787

  Fly   931 TGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYR 995
            |......:||||.|.|::...|||:.|||||:.:.:||::::. |:||..:|::.|   |..:.:
Mouse   788 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYG-ERPYWDMSNQDV---INAVEQ 848

  Fly   996 DYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            ||:    ||.|.:||..::.||.:||.||.:.||.|.:|
Mouse   849 DYR----LPPPMDCPTALHQLMLDCWVRDRNLRPKFSQI 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	95/291 (33%)
Ephb3	NP_034273.1	EphR_LBD_B3	31..203	CDD:198446
		Ephrin_rec_like	264..308	CDD:429604
		fn3	333..431	CDD:394996
		FN3	<468..537	CDD:238020
		EphA2_TM	555..625	CDD:464211	5/14 (36%)
		PTKc_EphR_B	623..891	CDD:173638	93/286 (33%)
		SAM_superfamily	917..985	CDD:472832
		PDZ-binding. /evidence=ECO:0000255	991..993