DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ddr and Epha8

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_031965.2 Gene:Epha8 / 13842 MGIID:109378 Length:1004 Species:Mus musculus


Alignment Length:687 Identity:157/687 - (22%)
Similarity:250/687 - (36%) Gaps:219/687 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   439 SAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVI---SPKPIDHQE---- 496
            ||||  |....: ||  .|||.|:....|.        |.||..|...:   .|..:.|.|    
Mouse   329 SAPV--NLISSV-NG--TSVTLEWAPPLDP--------GGRSDITYNAVCRRCPWALSHCEACGS 380

  Fly   497 ------PETSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPD-------- 547
                  .:||.....:.|...:..:..:|.:..|          ||:.    |.||:        
Mouse   381 GTRFVPQQTSLAQASLLVANLLAHMNYSFWIEAV----------NGVS----NLSPEPRSAAVVN 431

  Fly   548 -TLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIV 611
             |.|.....:||....:.......:.|:.||                            :.|:.:
Mouse   432 ITTNQAAPSQVVVIRQERAGQTSVSLLWQEP----------------------------EQPNGI 468

  Fly   612 CQDYAVPH------------MQQLLPNAPPCGSGCGT--------GTGTGPGRGSS--------- 647
            ..:|.:.:            ::.:...|...|...||        .|..|.||.|.         
Mouse   469 ILEYEIKYYEKDKEMQSYSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKP 533

  Fly   648 -PEF----------VVATGKVT--------------ASARNSLNAATLPLPSPPVPPPLEKYYAA 687
             |.:          .:.||.|.              :.|....:...:...:...|||:     .
Mouse   534 RPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPV-----F 593

  Fly   688 TPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEE--RANCQ 750
            .|::.      |||.......|:                :||.|            ||  ||.  
Mouse   594 LPLNH------PPGKFPETQFSA----------------EPHTY------------EEPGRAG-- 622

  Fly   751 VQEFPRQ---SLVIVEK-LGSGVFGELHLCETNV--LNATLVAVATLRPGANDHLRKEFRSKAKQ 809
             :.|.|:   |.:.:|| :|||..||:......|  .....||:..|:.|..:..|::|.|:|..
Mouse   623 -RSFTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLSEAAI 686

  Fly   810 LAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYIAT 874
            :.|...||:.||.|...|.....||.:|.. .|.|:.||:.|..:.:.:.         ||.:..
Mouse   687 MGQFDHPNIIRLEGVVTRGRLAMIVTEYME-NGSLDAFLRTHDGQFTIVQ---------LVGMLR 741

  Fly   875 QIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINR-------SAYASDYCQLEGFTG 932
            .:.:||::|..:.::|||||.|:.::...|..||...|  ::|       :||.:          
Mouse   742 GVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFG--LSRALEDDPEAAYTT---------- 794

  Fly   933 RQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDY 997
             ....:||||.|.|::....|::.||||||.|.:||:|.:. |:||.:::::.||.::...||  
Mouse   795 -AGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYG-ERPYWNMTNQDVISSVEEGYR-- 855

  Fly   998 KMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
                 ||.|..|||.::.||.:||.:|.:.||.|..:
Mouse   856 -----LPAPMGCPRALHQLMLDCWHKDRAQRPRFAHV 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 90/295 (31%)
Epha8NP_031965.2 EphR_LBD_A8 30..202 CDD:198454
FN3 <325..>518 CDD:442628 43/243 (18%)
FN3 439..530 CDD:238020 16/118 (14%)
EphA2_TM <561..631 CDD:464211 18/111 (16%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000269|PubMed:17875921 563..569 0/5 (0%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000269|PubMed:11416136 588..643 21/96 (22%)
Protein Kinases, catalytic domain 629..895 CDD:473864 88/290 (30%)
SAM_EPH-A8 932..994 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1002..1004
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.