Protein Alignment Ddr and Epha4

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_031962.2
• Gene: Epha4 / 13838
• MGIID: 98277
• Length: 986
• Species: Mus musculus
• Alignment Length: 578
• Identity: 148/578 - (25%)
• Similarity: 241/578 - (41%)
• Gaps: 160/578 - (27%)

  Fly   529 HVRSRENGL--------DAFQH-NFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYT 584
            |...::|||        |...| |::.:....|||.|...:.|.:.|             ..:.|
Mouse   385 HYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVS-------------VTVTT 436

  Fly   585 SAASACPMNDLQRQHVSPDYT--------DVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTG 641
            :.|:...:..:|.:.|: .|:        |.|:.|..:|.|.:.::
Mouse   437 NQAAPSSIALVQAKEVT-RYSVALAWLEPDRPNGVILEYEVKYYEK------------------- 481

  Fly   642 PGRGSSPEFVVATGKVTASARNS----LNAATLPLPSPPVPPPLEKYY----AATPVS----SKP 694
             .:......:|.|     :|||:    ||             ||..|.    |.|...    |:|
Mouse   482 -DQNERSYRIVRT-----AARNTDIKGLN-------------PLTSYVFHVRARTAAGYGDFSEP 527

  Fly   695 MPVAP---PGSQSSGSLSSSTTAATTPTSGVVGV-----------------------GKPHHYNL 733
            :.|..   | |:..|..::||....:.:..||.|                       .:..|.|.
Mouse   528 LEVTTNTVP-SRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQ 591

  Fly   734 DMSANFADINEERANCQVQEFPRQ---SLVIVEK-LGSGVFGEL-----------HLCETNVLNA 783
            .:.........|..|..|:||.::   |.:.:|| :|.|.|||:           .:|
Mouse   592 GVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIC------- 649

  Fly   784 TLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFL 848
              ||:.||:.|..|..|::|.|:|..:.|...||:..|.|...:.:|:.|:.:|.. .|.|:.||
Mouse   650 --VAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYME-NGSLDAFL 711

  Fly   849 QEHVAETSGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIG- 912
            :::....:.:.         ||.:...|.||||:|..|::||||||.|:.::...|..||...|
Mouse   712 RKNDGRFTVIQ---------LVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGM 767

  Fly   913 -TVINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQ 976
             .|:.....|:       :|.|..: :||||.|.|::...|||:.|||||:.:.:||::::. |:
Mouse   768 SRVLEDDPEAA-------YTTRGGK-IPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYG-ER 823

  Fly   977 PYEHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREI 1034
            ||..:|::.||:.|...||       ||.|.:||..::.||.:|||::.|.||.|.:|
Mouse   824 PYWDMSNQDVIKAIEEGYR-------LPPPMDCPIALHQLMLDCWQKERSDRPKFGQI 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	97/299 (32%)
Epha4	NP_031962.2	EphR_LBD_A4	30..203	CDD:198450
		FN3	<323..>547	CDD:442628	41/214 (19%)
		FN3	441..532	CDD:238020	23/129 (18%)
		EphA2_TM	562..618	CDD:464211	7/55 (13%)
		PTKc_EphR_A	616..882	CDD:270651	95/294 (32%)
		SAM_EPH-A4	911..981	CDD:188944
		PDZ-binding. /evidence=ECO:0000255	984..986