DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ddr and Epha3

DIOPT Version :10

Sequence 1:NP_001014474.3 Gene:Ddr / 3346209 FlyBaseID:FBgn0053531 Length:1054 Species:Drosophila melanogaster
Sequence 2:NP_034270.1 Gene:Epha3 / 13837 MGIID:99612 Length:984 Species:Mus musculus


Alignment Length:648 Identity:152/648 - (23%)
Similarity:250/648 - (38%) Gaps:221/648 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   445 NFTDELANGEKQ----SVTSE-------YPLQRDEVGR-AISSGGERSQHTTQVI---SPKPIDH 494
            |...||::..:|    |:|:.       ..:::|...| :||...:..:|...:|   ..|..:.
Mouse   413 NGVSELSSPPRQYAAVSITTNQAAPSPVMTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEK 477

  Fly   495 QEPETSFVGVIITVLGTIIMLL-----VAFILLIVARNK---HVRSRENGLDAFQHNFSPDTLNG 551
            ||.|||:  .|:...||.:.:.     ..::..|.||..   ...||:     |:...|||:.:.
Mouse   478 QEQETSY--TILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTNSRK-----FEFETSPDSFSI 535

  Fly   552 NG-----------------VLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQH 599
            :|                 ||.|||.:     .:.:...||:        |..||    :.:|.|
Mouse   536 SGENSHVVMIAISAAVAIIVLTVVTYV-----LVGRFCGYHK--------SKHSA----EEKRLH 583

  Fly   600 VSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGRGSSPEFVVATGKVTASARNS 664
            ....:..:|.:  :.|..||..:                                          
Mouse   584 FGNGHLKLPGL--RTYVDPHTYE------------------------------------------ 604

  Fly   665 LNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPH 729
                                                                .||..|      |
Mouse   605 ----------------------------------------------------DPTQAV------H 611

  Fly   730 HYNLDMSANFADINEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNV----LNATLVAVAT 790
            .:..::.|.                   ::.|.:.:|:|.|||  :|...:    .....||:.|
Mouse   612 EFAKELDAT-------------------NISIDKVVGAGEFGE--VCSGRLKLPSKKEISVAIKT 655

  Fly   791 LRPGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAET 855
            |:.|..:..|::|..:|..:.|...||:.||.|...:.:|:.||.:|.. .|.|:.||::|.|:.
Mouse   656 LKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYME-NGSLDSFLRKHDAQF 719

  Fly   856 SGLMAKKSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIG--TVINRS 918
            :.:.         ||.:...||||||:|..|.:||||||.|:.:|...|..||...|  .|:...
Mouse   720 TVIQ---------LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDD 775

  Fly   919 AYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSD 983
            ..|:       :|.|..: :||||.:.|::...|||:.|||||:.:.|||::::. |:||..:|:
Mouse   776 PEAA-------YTTRGGK-IPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYG-ERPYWEMSN 831

  Fly   984 KSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQR--KNLG 1044
            :.||:.:...||       ||.|.:||..:|.||.:|||:|.::||.|.:|...|.:  :|.|
Mouse   832 QDVIKAVDEGYR-------LPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPG 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DdrNP_001014474.3 FA58C 109..261 CDD:238014
PTKc_DDR 753..1040 CDD:270644 98/292 (34%)
Epha3NP_034270.1 EphR_LBD_A3 29..201 CDD:198449
FN3 <323..>516 CDD:442628 24/104 (23%)
FN3 437..528 CDD:238020 21/97 (22%)
EphA2_TM <566..619 CDD:464211 15/166 (9%)
PTKc_EphR_A 617..883 CDD:270651 99/312 (32%)
SAM_EPH-A3 913..975 CDD:188943
PDZ-binding. /evidence=ECO:0000255 982..984
Blue background indicates that the domain is not in the aligned region.

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