Protein Alignment Ddr and Epha1

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: NP_076069.2
• Gene: Epha1 / 13835
• MGIID: 107381
• Length: 977
• Species: Mus musculus
• Alignment Length: 301
• Identity: 99/301 - (32%)
• Similarity: 153/301 - (50%)
• Gaps: 47/301 - (15%)

  Fly   752 QEFPRQSLVIVEKLGSGVFGELHL---------CETNVLNATLVAVATLRPGANDHLRKEFRSKA 807
            ||.....|::...:|.|.|||::.         |:|       ||:.||:..:.|.....|..:|
Mouse   618 QELDPAWLIVDTVIGEGEFGEVYRGALRLPSQDCKT-------VAIKTLKDTSPDGYWWNFLREA 675

  Fly   808 KQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVYI 872
            ..:.|.:.|::.||.|...:.:||.|:.::.. .|.|:.||:|.         :..|:.|.||.:
Mouse   676 TIMGQFNHPHILRLEGVITKRKPIMIITEFME-NGALDAFLKER---------EDQLAPGQLVAM 730

  Fly   873 ATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTG---RQ 934
            ...|||||..|...|:||||||.|:.::...||.||...|  :.|        .|:.|.|   .|
Mouse   731 LLGIASGMNCLSGHNYVHRDLAARNILVNQNLCCKVSDFG--LTR--------LLDDFDGTYETQ 785

  Fly   935 SQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKM 999
            ...:||||.|.|::....|||.||||||.:.:||:|:|. ::||..:|::.|:::|...||
Mouse   786 GGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFG-DKPYGEMSNQEVMKSIEDGYR---- 845

  Fly  1000 HELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQR 1040
               ||.|.:||..:|:||..||..|.:.||.|.::..:|::
Mouse   846 ---LPPPVDCPAPLYELMKNCWAYDRARRPHFLQLQAHLEQ 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014
		PTKc_DDR	753..1040	CDD:270644	98/298 (33%)
Epha1	NP_076069.2	EphR_LBD_A1	28..204	CDD:198447
		fn3	335..426	CDD:394996
		FN3	454..536	CDD:238020
		EphA2_TM	<596..622	CDD:464211	2/3 (67%)
		Protein Kinases, catalytic domain	620..885	CDD:473864	97/299 (32%)
		SAM_EPH-A1	913..975	CDD:188941
		PDZ-binding. /evidence=ECO:0000255	975..977