DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and Ddr1

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	NP_001185760.1	Gene:	Ddr1 / 12305	MGIID:	99216	Length:	911	Species:	Mus musculus

Alignment Length:	1035	Identity:	323/1035 - (31%)
Similarity:	478/1035 - (46%)	Gaps:	194/1035 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TLCWLTLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMESGAIADFQITASS 126
            ||..|.|.|:|:                 .:|...:........|:.||||:...|.|..|:.||
Mouse     5 TLSSLLLLLLLV-----------------TIGDADMKGHFDPAKCRYALGMQDRTIPDSDISVSS 52

  Fly   127 AHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGVHLVSAIRTQGRFGKGQGQEYT 191
            :.. .:...:|:||:..:..|||||...|.....|||||||..:|||:.:.||||...|.|:|::
Mouse    53 SWS-DSTAARHSRLESSDGDGAWCPAGPVFPKEEEYLQVDLRRLHLVALVGTQGRHAGGLGKEFS 116

  Fly   192 EAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRLYPYSQYDRTVCLR 256
            .:|.:.|.|.| ::|:.|:...|:||:.||.:....|...|.|.:.|..||.||.:....:||||
Mouse   117 RSYRLRYSRDG-RRWMDWKDRWGQEVISGNEDPGGVVLKDLGPPMVARLVRFYPRADRVMSVCLR 180

  Fly   257 AEIVGCAWEEGIVSYSIPKGMQRGMD---IDLSDKTYDGYEEGDHYVNGLGQLVDGQRGKDNFRA 318
            .|:.||.|.:|::||:.|.|....:.   :.|:|.|||||..|.....|||||.||..|.|:||.
Mouse   181 VELYGCLWRDGLLSYTAPVGQTMQLSEVMVHLNDSTYDGYTAGGLQYGGLGQLADGVVGLDDFRQ 245

  Fly   319 DIN-GLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFVHAKVFFSIG 382
            ... .:..||:::||.|.:.....||:.|||:.:|....:.:|.|||.:...::....:..|..|
Mouse   246 SQELRVWPGYDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPGGVECRFKRG 310

  Fly   383 -GRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMISEITFISAPVVGNF 446
             ...:.||||:.:....|....||.:::.|...:||::|....||..|::.|||:||| .||.:.
Mouse   311 PAMAWEGEPVRHALGGSLGDPRARAISVPLGGHVGRFLQCRFLFAGPWLLFSEISFIS-DVVNDS 374

  Fly   447 TDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEP----ETSFVGVIIT 507
            :|..      .....:|           .|...:..::..:.|:   .|:|    |.|...::|.
Mouse   375 SDTF------PPAPWWP-----------PGPPPTNFSSLELEPR---GQQPVAKAEGSPTAILIG 419

  Fly   508 VLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNS 572
            .|..||:||:..|.|::.| .|.|..   |...:.....:.|..:..:...|.:.:|.....:..
Mouse   420 CLVAIILLLLLIIALMLWR-LHWRRL---LSKAERRVLEEELTVHLSVPGDTILINNRPGPREPP 480

  Fly   573 LYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAPPCGSGCGTG 637
            .|.||                   |...:|               ||....:||    ||....
Mouse   481 PYQEP-------------------RPRGTP---------------PHSAPCVPN----GSALLL- 506

  Fly   638 TGTGPGRGSSPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSS---------- 692
                    |:|.:.:.........|.         |.||.|.      .|.|.::
Mouse   507 --------SNPAYRLLLATYARPPRG---------PGPPTPA------WAKPTNTQACSGDYMEP 548

  Fly   693 -KP-MPVAPPGSQSS-------------GSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADI 742
             || .|:.||..|:|             |....:|.|......|.||.|.|.
Mouse   549 EKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPR------------- 600

  Fly   743 NEERANCQVQEFPRQSLVIVEKLGSGVFGELHLCET----NVLNA-----------TLVAVATLR 792
                     .:|||..|...||||.|.|||:||||.    :::::           .||||..||
Mouse   601 ---------VDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILR 656

  Fly   793 PGANDHLRKEFRSKAKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAE--- 854
            |.|..:.|.:|..:.|.:::|.|||:.||:|.|::|:|:|::.||.. .|||||||.....|
Mouse   657 PDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYME-NGDLNQFLSARQLENKA 720

  Fly   855 TSGLMAK------KSLSFGCLVYIATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGT 913
            |.||...      .::|:..|:::..||||||::|..:||||||||||:|::|....:|:...|
Mouse   721 TQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG- 784

  Fly   914 VINRSAYASDYCQLEGFTGRQSQPMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPY 978
             ::|:.||.||.:::|     ...:||||||||.:|:|||||.||||:|.|.|||:|...|.||:
Mouse   785 -MSRNLYAGDYYRVQG-----RAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPF 843

  Fly   979 EHLSDKSVIENIGLIYRDYKMHELLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            ..|:|:.||||.|..:||......|..||.||:.:|:||..||.|:...||.|.::|.:|
Mouse   844 GQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQTLYELMLRCWSREPEQRPPFAQLHRFL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	60/155 (39%)
		FA58C	109..261	CDD:238014	59/151 (39%)
		PTKc_DDR	753..1040	CDD:270644	132/310 (43%)
		TyrKc	759..1038	CDD:197581	128/302 (42%)
Ddr1	NP_001185760.1	FA58C	58..185	CDD:238014	50/127 (39%)
		DS-like domain. /evidence=ECO:0000250	193..369		60/176 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..496		8/61 (13%)
		PPxY motif	479..482		0/2 (0%)
		PKc_like	602..905	CDD:419665	132/310 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	265	1.000	Domainoid score	I1888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1219
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm8799
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010