DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and ddr2

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	XP_002933824.2	Gene:	ddr2 / 100497889	XenbaseID:	XB-GENE-983827	Length:	873	Species:	Xenopus tropicalis

Alignment Length:	1016	Identity:	336/1016 - (33%)
Similarity:	485/1016 - (47%)	Gaps:	177/1016 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 CRIKRHGVNNSKTLCWLTLTLILLANRFGMGTAVGTPETPAAVGSNGLLAEMPIGTCKQALGMES 114
            ||..|     .|:...|.|.|.||     :.::|.:...||              .|:..|||..
Frog     5 CRKMR-----GKSQIPLILPLFLL-----ILSSVESQVNPA--------------VCRYPLGMSG 45

  Fly   115 GAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVS-RGLTEYLQVDLLGVHLVSAIRT 178
            |.|.|..|||||... .:...::.||..:...|||||:..|. ..|||:||:||..:|.::.:.|
Frog    46 GHIPDEDITASSQWS-ESTAAKYGRLDSEGGDGAWCPEMPVDPEELTEFLQIDLRVLHFITLVGT 109

  Fly   179 QGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPSVFASKVRL 243
            |||...|.|.|:.:.:.|.|.|.| .:||.||:..|::||.||:|.|..|...|:|.:.|..:|.
Frog   110 QGRHAGGHGNEFAQMFKINYSRDG-TRWISWRNRHGRQVLDGNVNPYDIVLKDLEPPIVARFLRF 173

  Fly   244 YPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQ----RGMDIDLSDKTYDGYEEGDHYVNGLG 304
            .|.:.:...||||.|:.||.|.:|:|||:.|.|.|    .|..|.|:|..||| ..|.....|||
Frog   174 IPVTDHSMNVCLRVELYGCVWLDGLVSYNAPSGQQFLLPEGYAIYLNDTIYDG-AIGYSMTEGLG 237

  Fly   305 QLVDGQRGKDNFRADIN-GLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKD 368
            ||.||..|.|:|..... .:..||:::||.|::.....|||:|||:.:||.:.:.:|.||||||.
Frog   238 QLTDGVSGLDDFTLTHEYHMWPGYDYVGWSNESFSNGYVEIVFEFDRIRNFTTMKVHCNNMFSKG 302

  Fly   369 VQVFVHAKVFFSIGGRHFSGEPVQFSYMPDLVLDHARDVTIKLHHRLGRYVQLHLYFAARWMMIS 433
            |::|...:.||......:....:..:.:.|.....||.||::||:.:.|.::.|.|||..|||.|
Frog   303 VKIFKDVQCFFRSDANEWEANSISSTLVLDDANPSARYVTVQLHNHMARAIKCHYYFADSWMMFS 367

  Fly   434 EITFISAPVVGNFTDELANGEKQSVTSEYPLQRDEVGRAISSGGERSQHTTQVISPKPIDHQEPE 498
            ||||.|...:  :.:.:...:..||.:.|                  ..|.:|           :
Frog   368 EITFQSDAAM--YNNSMNPPQPASVPTTY------------------DPTLKV-----------D 401

  Fly   499 TSFVGVIITVLGTIIMLLVAFILLIVARNKHVRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDD 563
            .|...::|..|..||.:|||.|::|:.|....:..|                     |....|.|
Frog   402 DSNTRILIGCLVAIIFILVAIIVIILWRQFWQKMLE---------------------KASRRMLD 445

  Fly   564 NESSIDKNSLYHEPFNANMYTSAASACPMNDLQRQHVSPDYTDVPDIVCQDYAVPHMQQLLPNAP 628
            .|.::..:.    |.:::||.:          .|:|.|...::.......|       ::.|..|
Frog   446 EELTVSLSL----PSDSSMYNT----------NRRHDSVSASEQESNSTYD-------RIFPLGP 489

  Fly   629 PCGSGCGTGTGTGPGR--GSSPEFVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVS 691
            ....         |.|  ...|||...|.....:|.:|...:.||..:..||     :||...:.
Frog   490 DYQE---------PTRLIRKLPEFTAQTVGEEETAGSSAGKSALPASADGVP-----HYAEADIV 540

  Fly   692 SKPMPVAPPGSQSSGSLSSSTTAATTPTSGVVGVGKPHHYNLDMSANFADINEERANCQVQEFPR 756
            :           ..|....:|.:....|..::. ||                    ...|:||||
Frog   541 N-----------LQGVTGGNTYSVPAITMDLLS-GK--------------------EVAVEEFPR 573

  Fly   757 QSLVIVEKLGSGVFGELHLC---------------ETNVLNATLVAVATLRPGANDHLRKEFRSK 806
            :.|...||||.|.|||:|||               ||:....|||||..||..||.:.|.:|..:
Frog   574 KHLTFKEKLGEGQFGEVHLCEAEGVEEFLDKDLILETSPGQPTLVAVKMLRADANKNARNDFLKE 638

  Fly   807 AKQLAQLSDPNVARLVGACLRDEPICIVQDYSHCLGDLNQFLQEHVAETSGLMAKKSLSFGCLVY 871
            .|.:::|.|||:.||:..|:.::|:|::.:|.. .|||||||.....|.....|...:|:..|.:
Frog   639 IKIMSRLKDPNIIRLLAVCIAEDPLCMITEYME-NGDLNQFLSRQQPEGGLPAATLPISYTDLRH 702

  Fly   872 IATQIASGMKHLEQMNFVHRDLATRSCIIGPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQ 936
            :|.|||||||:|..:||||||||||:|::|....:|:...|  ::|:.|:.||.:::|     ..
Frog   703 MAAQIASGMKYLSSLNFVHRDLATRNCLVGRNYTIKIADFG--MSRNLYSGDYYRIQG-----RA 760

  Fly   937 PMPIRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHE 1001
            .:|||||:|||:|||||||.||||:|||.|||.|||.|||||..:||:.||||.|..:||.....
Frog   761 VLPIRWMSWESILLGKFTTASDVWAFAVTLWETLTFCREQPYSEMSDEQVIENTGEFFRDQGKQV 825

  Fly  1002 LLPMPPNCPREIYDLMCECWQRDESSRPSFREIHLYLQRKN 1042
            .||.|..||..:|.||..||:|:...||||:||...||.::
Frog   826 YLPKPNICPERVYKLMLSCWRRETKDRPSFQEICQSLQSES 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	61/156 (39%)
		FA58C	109..261	CDD:238014	60/152 (39%)
		PTKc_DDR	753..1040	CDD:270644	139/301 (46%)
		TyrKc	759..1038	CDD:197581	134/293 (46%)
ddr2	XP_002933824.2	FA58C	39..191	CDD:238014	60/153 (39%)
ddr2	XP_002933824.2	PTKc_DDR2	570..864	CDD:270677	139/301 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1800
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68505
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm9464
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090