DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ddr and ddr1

DIOPT Version :9

Sequence 1:	NP_001014474.3	Gene:	Ddr / 3346209	FlyBaseID:	FBgn0053531	Length:	1054	Species:	Drosophila melanogaster
Sequence 2:	XP_009290548.1	Gene:	ddr1 / 100007346	ZFINID:	ZDB-GENE-060323-2	Length:	974	Species:	Danio rerio

Alignment Length:	1009	Identity:	341/1009 - (33%)
Similarity:	487/1009 - (48%)	Gaps:	153/1009 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGV 170
            |:.|||||.|.|.|..||||||.. .:...:|.||......|||||...|....:|:|||||..:
Zfish    35 CRYALGMEDGVIPDSDITASSAWS-DSTEAKHGRLSNGEGDGAWCPAGPVFPSASEFLQVDLRKL 98

  Fly   171 HLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPS 235
            |.:|.:.||||...|.|:|:..:|.:.|.|.| :.|:.|:...|:||:.||.|||..|...|.|.
Zfish    99 HFLSLVGTQGRHADGLGREFARSYRLRYSRDG-RHWMTWKDRWGQEVVSGNENTYDIVLKDLGPP 162

  Fly   236 VFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQRGMD-----IDLSDKTYDGYEE 295
            :.|..||.||.:....:||||.|:.||.|::|:.:|:.|.|  ..||     ::.:|..|||.:|
Zfish   163 IIARMVRFYPLADRVMSVCLRVELYGCVWKDGLKAYTAPLG--HVMDLSGSLVNFNDSVYDGSKE 225

  Fly   296 GDHYVNGLGQLVDGQRGKDNFRADIN-GLGKGYEWIGWRNDTLLGRP-VEIIFEFETVRNLSAVI 358
            |.....|||||.||..|.::|..... .:..||:::||..:| ||:| |:|.|.||..|....:.
Zfish   226 GGVIFGGLGQLCDGVLGGNDFMESKELRVWPGYDYVGWNRET-LGQPTVDIEFHFEKTRIFHTMQ 289

  Fly   359 IHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEP---VQFSYMPDLVLDHARDVTIKLHHRLGRYVQ 420
            :|:||..::.|:||......|.........||   :|.|.:.||   .:|.:::.|..|..:.::
Zfish   290 VHSNNRHTQGVRVFSEVVCKFKASLLSPWAEPELSLQVSDLHDL---SSRTISLPLGGRPAQILR 351

  Fly   421 LHLYFAARWMMISEITFISAPVVGNFTD-------ELANGEKQSVTSEYPLQRDEVGRAI----- 473
            .|..||..|::||||:|.|.|    |.|       ..::....:.||..|:..:......
Zfish   352 CHFAFADNWLLISEISFYSMP----FEDGSVLPPIPSSSSRPLNATSYSPITANATSSPTNLLMT 412

  Fly   474 -------SSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARN--KH 529
                   |...|.|..|.:|..|...|    ::|...::|..|..||:||:|.|::|:.|.  |.
Zfish   413 NSSLLPSSMPTEMSGITLRVGIPVAKD----DSSHTAILIGCLVGIILLLLAVIVVILWRQYWKK 473

  Fly   530 VRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMND 594
            :..:..|      :.|.|.|..:             .|:..:::.....|.:.|:|.
Zfish   474 LLGKAQG------SLSSDELRVH-------------LSVPSDNVVINNTNTHTYSSR-------- 511

  Fly   595 LQRQHVSPDYTD------VPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGR----GSSPE 649
            .||.|..||..|      .|..|.:.........||.|.|.........| .||.|    .|..|
Zfish   512 YQRIHTFPDDRDREGEYQEPSTVLRPRDQRDSTALLLNNPAYHLLLSDLT-HGPNRLTNCHSQQE 575

  Fly   650 FVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPG------SQSSGSL 708
                 ..:..|...:::.....||....|||    |...|         |||      .::||..
Zfish   576 -----KPLNLSQACAIDMVDKGLPIQEGPPP----YPGAP---------PPGLSGAHYGEASGGG 622

  Fly   709 SSSTTAATTPTSGVVGVGKPHHYNLD-MSANFADINEERANC-QVQEFPRQSLVIVEKLGSGVFG 771
            :|....|......:.||...:.|.:. :||...|       | .:.|.||:.||..||||.|.||
Zfish   623 ASVPHYAEADIISLQGVSGNNTYAVPALSATPTD-------CPPLPELPRERLVFKEKLGEGQFG 680

  Fly   772 ELHLCET-------------NVLNA--TLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARL 821
            |:||||.             ||...  .||||..|||.|:.:.|.:|..:.|.|::|.|||:.||
Zfish   681 EVHLCEIENPQDLANLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRL 745

  Fly   822 VGACLRDEPICIVQDYSHCLGDLNQFLQEHV-AETSG-LMAKKSLSFGCLVYIATQIASGMKHLE 884
            :|.|:..:|:|:|.:|... |||||:|...| .:.|| .....::|:..|:.:|:|||||||.|.
Zfish   746 LGVCVSSDPLCMVTEYMES-GDLNQYLSHRVLLDKSGPSQNTPTISYPALISMASQIASGMKFLA 809

  Fly   885 QMNFVHRDLATRSCII----------GPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMP 939
            .:||||||||||:|::          |.|..:|:...|  ::|:.||.||.:::|     ...:|
Zfish   810 SLNFVHRDLATRNCLVGGERGESEERGGERHIKIADFG--MSRNLYAGDYYRIQG-----RAVLP 867

  Fly   940 IRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLP 1004
            |||||||.:|:|||||.||||:|.|.|||:|:..:||||.|::|:.||:|.|..:||......|.
Zfish   868 IRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDQGRQVYLS 932

  Fly  1005 MPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            .|..||:.:|:||..||.||...||||..||.:|
Zfish   933 RPAVCPQGLYELMLSCWNRDCKLRPSFAYIHSFL 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	106..262	CDD:214572	66/155 (43%)
		FA58C	109..261	CDD:238014	65/151 (43%)
		PTKc_DDR	753..1040	CDD:270644	138/313 (44%)
		TyrKc	759..1038	CDD:197581	134/305 (44%)
ddr1	XP_009290548.1	FA58C	34..189	CDD:214572	66/155 (43%)
		FA58C	37..188	CDD:238014	65/152 (43%)
		PKc_like	662..968	CDD:304357	138/313 (44%)
		TyrKc	668..966	CDD:197581	134/305 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1794
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1210
OMA	1	1.010	-	-		QHG45751
OrthoDB	1	1.010	-	-		D122892at33208
OrthoFinder	1	1.000	-	-		FOG0001292
OrthoInspector	1	1.000	-	-		mtm6449
orthoMCL	1	0.900	-	-		OOG6_103661
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4211
SonicParanoid	1	1.000	-	-		X998
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010