Protein Alignment Ddr and ddr1

DIOPT Version :10

• Sequence 1: NP_001014474.3
• Gene: Ddr / 3346209
• FlyBaseID: FBgn0053531
• Length: 1054
• Species: Drosophila melanogaster
• Sequence 2: XP_009290548.1
• Gene: ddr1 / 100007346
• ZFINID: ZDB-GENE-060323-2
• Length: 974
• Species: Danio rerio
• Alignment Length: 1009
• Identity: 341/1009 - (33%)
• Similarity: 487/1009 - (48%)
• Gaps: 153/1009 - (15%)

  Fly   106 CKQALGMESGAIADFQITASSAHDMGNVGPQHARLKIDNNGGAWCPKHMVSRGLTEYLQVDLLGV 170
            |:.|||||.|.|.|..||||||.. .:...:|.||......|||||...|....:|:|||||..:
Zfish    35 CRYALGMEDGVIPDSDITASSAWS-DSTEAKHGRLSNGEGDGAWCPAGPVFPSASEFLQVDLRKL 98

  Fly   171 HLVSAIRTQGRFGKGQGQEYTEAYVIEYWRPGLKKWIRWRSLQGKEVLPGNINTYSEVENVLQPS 235
            |.:|.:.||||...|.|:|:..:|.:.|.|.| :.|:.|:...|:||:.||.|||..|...|.|.
Zfish    99 HFLSLVGTQGRHADGLGREFARSYRLRYSRDG-RHWMTWKDRWGQEVVSGNENTYDIVLKDLGPP 162

  Fly   236 VFASKVRLYPYSQYDRTVCLRAEIVGCAWEEGIVSYSIPKGMQRGMD-----IDLSDKTYDGYEE 295
            :.|..||.||.:....:||||.|:.||.|::|:.:|:.|.|  ..||     ::.:|..|||.:|
Zfish   163 IIARMVRFYPLADRVMSVCLRVELYGCVWKDGLKAYTAPLG--HVMDLSGSLVNFNDSVYDGSKE 225

  Fly   296 GDHYVNGLGQLVDGQRGKDNFRADIN-GLGKGYEWIGWRNDTLLGRP-VEIIFEFETVRNLSAVI 358
            |.....|||||.||..|.::|..... .:..||:::||..:| ||:| |:|.|.||..|....:.
Zfish   226 GGVIFGGLGQLCDGVLGGNDFMESKELRVWPGYDYVGWNRET-LGQPTVDIEFHFEKTRIFHTMQ 289

  Fly   359 IHTNNMFSKDVQVFVHAKVFFSIGGRHFSGEP---VQFSYMPDLVLDHARDVTIKLHHRLGRYVQ 420
            :|:||..::.|:||......|.........||   :|.|.:.||   .:|.:::.|..|..:.::
Zfish   290 VHSNNRHTQGVRVFSEVVCKFKASLLSPWAEPELSLQVSDLHDL---SSRTISLPLGGRPAQILR 351

  Fly   421 LHLYFAARWMMISEITFISAPVVGNFTD-------ELANGEKQSVTSEYPLQRDEVGRAI----- 473
            .|..||..|::||||:|.|.|    |.|       ..::....:.||..|:..:......
Zfish   352 CHFAFADNWLLISEISFYSMP----FEDGSVLPPIPSSSSRPLNATSYSPITANATSSPTNLLMT 412

  Fly   474 -------SSGGERSQHTTQVISPKPIDHQEPETSFVGVIITVLGTIIMLLVAFILLIVARN--KH 529
                   |...|.|..|.:|..|...|    ::|...::|..|..||:||:|.|::|:.|.  |.
Zfish   413 NSSLLPSSMPTEMSGITLRVGIPVAKD----DSSHTAILIGCLVGIILLLLAVIVVILWRQYWKK 473

  Fly   530 VRSRENGLDAFQHNFSPDTLNGNGVLKVVTTMDDNESSIDKNSLYHEPFNANMYTSAASACPMND 594
            :..:..|      :.|.|.|..:             .|:..:::.....|.:.|:|.
Zfish   474 LLGKAQG------SLSSDELRVH-------------LSVPSDNVVINNTNTHTYSSR-------- 511

  Fly   595 LQRQHVSPDYTD------VPDIVCQDYAVPHMQQLLPNAPPCGSGCGTGTGTGPGR----GSSPE 649
            .||.|..||..|      .|..|.:.........||.|.|.........| .||.|    .|..|
Zfish   512 YQRIHTFPDDRDREGEYQEPSTVLRPRDQRDSTALLLNNPAYHLLLSDLT-HGPNRLTNCHSQQE 575

  Fly   650 FVVATGKVTASARNSLNAATLPLPSPPVPPPLEKYYAATPVSSKPMPVAPPG------SQSSGSL 708
                 ..:..|...:::.....||....|||    |...|         |||      .::||..
Zfish   576 -----KPLNLSQACAIDMVDKGLPIQEGPPP----YPGAP---------PPGLSGAHYGEASGGG 622

  Fly   709 SSSTTAATTPTSGVVGVGKPHHYNLD-MSANFADINEERANC-QVQEFPRQSLVIVEKLGSGVFG 771
            :|....|......:.||...:.|.:. :||...|       | .:.|.||:.||..||||.|.||
Zfish   623 ASVPHYAEADIISLQGVSGNNTYAVPALSATPTD-------CPPLPELPRERLVFKEKLGEGQFG 680

  Fly   772 ELHLCET-------------NVLNA--TLVAVATLRPGANDHLRKEFRSKAKQLAQLSDPNVARL 821
            |:||||.             ||...  .||||..|||.|:.:.|.:|..:.|.|::|.|||:.||
Zfish   681 EVHLCEIENPQDLANLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKDPNIIRL 745

  Fly   822 VGACLRDEPICIVQDYSHCLGDLNQFLQEHV-AETSG-LMAKKSLSFGCLVYIATQIASGMKHLE 884
            :|.|:..:|:|:|.:|... |||||:|...| .:.|| .....::|:..|:.:|:|||||||.|.
Zfish   746 LGVCVSSDPLCMVTEYMES-GDLNQYLSHRVLLDKSGPSQNTPTISYPALISMASQIASGMKFLA 809

  Fly   885 QMNFVHRDLATRSCII----------GPELCVKVCSIGTVINRSAYASDYCQLEGFTGRQSQPMP 939
            .:||||||||||:|::          |.|..:|:...|  ::|:.||.||.:::|     ...:|
Zfish   810 SLNFVHRDLATRNCLVGGERGESEERGGERHIKIADFG--MSRNLYAGDYYRIQG-----RAVLP 867

  Fly   940 IRWMAWESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLP 1004
            |||||||.:|:|||||.||||:|.|.|||:|:..:||||.|::|:.||:|.|..:||......|.
Zfish   868 IRWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDQGRQVYLS 932

  Fly  1005 MPPNCPREIYDLMCECWQRDESSRPSFREIHLYL 1038
            .|..||:.:|:||..||.||...||||..||.:|
Zfish   933 RPAVCPQGLYELMLSCWNRDCKLRPSFAYIHSFL 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddr	NP_001014474.3	FA58C	109..261	CDD:238014	65/151 (43%)
		PTKc_DDR	753..1040	CDD:270644	138/313 (44%)
ddr1	XP_009290548.1	FA58C	37..188	CDD:238014	65/152 (43%)
		Protein Kinases, catalytic domain	662..968	CDD:473864	138/313 (44%)