DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	351	Identity:	64/351 - (18%)
Similarity:	101/351 - (28%)	Gaps:	151/351 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LPIF-DFGM--PR-----------------NITGRTGHTEAIIKCRVDSLHDKSV--------SW 271
            |||| .||:  ||                 .|.|.....:...:|||..| |:.:        ||
Human    64 LPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFL-DQHIPEDDFANGSW 127

  Fly   272 IRKRDLHILTVGTATYTSDKRFQVT-------------------------------ESKD----- 300
            :     |:      |..|..:||.|                               ..||
Human   128 V-----HL------TVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQ 181

  Fly   301 ----SREWTLHVKAPLAKDSGIYECQV-NTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGS 360
                .:..||.::......||:|.||. :||...:.|.||.::    ....::..|.:....|..
Human   182 GQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVL----GPPVIVVPPKNSTVNASQ 242

  Fly   361 AIILNCLVQQPSVKDIGPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVD 425
            .:.|.|                                        |.:..|.:.:.:.....::
Human   243 DVSLAC----------------------------------------HAEAYPANLTYSWFQDNIN 267

  Fly   426 L----QMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTCQPTTA----SSASVLVHVI---- 478
            :    :::...||.::..        ||:...|..|.|.|||.|:..    .|||..:.|:
Human   268 VFHISRLQPRVRILVDGS--------LRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQ 324

  Fly   479 ----NDENPAAMQKSGA--CPCALGP 498
                ..|.|..:...|.  ||....|
Human   325 VTAMPPETPLPIGMPGVIRCPVRANP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	28/152 (18%)
		IG_like	243..329	CDD:214653	28/151 (19%)
		Ig	350..464	CDD:299845	15/117 (13%)
		IG_like	<441..477	CDD:214653	12/39 (31%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845	18/79 (23%)
		IG_like	28..110	CDD:214653	11/45 (24%)
		I-set	136..223	CDD:254352	17/86 (20%)
		Ig	154..220	CDD:143165	12/65 (18%)
		Ig_3	226..305	CDD:290638	17/126 (13%)
		IG_like	233..319	CDD:214653	20/133 (15%)
		Ig	341..404	CDD:299845	3/10 (30%)
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810