DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr3 and aebp1b

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_696022.6	Gene:	aebp1b / 567630	ZFINID:	ZDB-GENE-030131-8546	Length:	1247	Species:	Danio rerio

Alignment Length:	488	Identity:	84/488 - (17%)
Similarity:	142/488 - (29%)	Gaps:	160/488 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VIVKQHKEQQHQQHQQQHRQDQQDQKDPRAAKQICNINLCGFLRRSGADDVDVIEPRSPGHAADV 70
            :|:|:.:....::.:::..::.:..|.|:|:|......    ..:.|..:....:..........
Zfish   147 IILKRMRRDTDRKGREKRLKEPKPSKKPKASKPTKKPK----SEKKGKGEKGGKKKGKKNREEST 207

  Fly    71 DVAAAAAGATTSV--------------------AATAAAAAAATTRAAATTRAVIIIMALVVSIM 115
            .||......||:|                    .|.....|..||.....|:..|..|.   ...
Zfish   208 TVATTTVAPTTTVPMEYEEFYDPEPDQYWDEDFPAETTTVARTTTTPTEKTKDFIPDMD---EYS 269

  Fly   116 QQQQQSLLWPFCNGLAAAAASTGQPDDSG-----------------DGPTLSTFLSSSQ---SQS 160
            |.......|.........:...|:|.|..                 ||..:|:..:..|   ::.
Zfish   270 QPDSYDDYWKVDEPTPTTSVIAGRPADDDDYWDARSVEMVENLPFPDGKEISSTDNDWQYTTTEE 334

  Fly   161 PS-PPAASASASSPSSFSSFAVAHGPQTEATNHTFKSLAFLDASFGSDLFAQTDAKRERSGAADE 224
            |: ||..:      |.:..:...|..:.|......:.             .|.:.:||.....:|
Zfish   335 PTVPPFEN------SWYEEYEYGHEKKLEEERERLRK-------------EQEEKEREERKRLEE 380

  Fly   225 ESQD--------------------------ADTSQSL--PIFDFGMPRNITGRTGHTEAIIKCRV 261
            |.::                          .|..|.|  .:|..        |.|...|.:..:.
Zfish   381 EERERRIYRPPPRVYREPKICPPLGMESHRIDNDQLLTSSVFQH--------RYGSHRARLNIQA 437

  Fly   262 ----DSLH--------DKSVSWIRKRDLHILTVGTATYTSDK----------RFQVTESKDSREW 304
                |.::        ::.|.|| :.|...||..|...|..:          .:.|..|.|||||
Zfish   438 SGDDDDMNGGAWCANPEEKVHWI-EVDARTLTEFTGVITQGRDDPLESDYVSTYYVAFSNDSREW 501

  Fly   305 T-LHVKAPLAKDSGIYE------CQVNTEPKMSMAFQ---LNIIEISPDAKAVISGPPDLHFKAG 359
            | ||        .|..|      ...|| |.:|...:   ...|.|.|.:   .:|...:..:
Zfish   502 TFLH--------DGYAEWLFFGNSDKNT-PVLSQFMEPVVARYIRILPQS---WNGTMCMRME-- 552

  Fly   360 SAIILNCLVQQPSVKDIGPIYWYRGEHMITPFD 392
               ||.|.||.       |:..::.|:.:|..|
Zfish   553 ---ILGCPVQD-------PLSQHQSENEVTRRD 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	27/115 (23%)
		IG_like	243..329	CDD:214653	27/114 (24%)
		Ig	350..464	CDD:299845	10/43 (23%)
		IG_like	<441..477	CDD:214653
aebp1b	XP_696022.6	Ig	56..147	CDD:299845	84/488 (17%)
		IG_like	62..145	CDD:214653
		FA58C	402..555	CDD:238014	37/178 (21%)
		FA58C	403..556	CDD:214572	38/178 (21%)
		Peptidase_M14_like	577..1036	CDD:299699
		Peptidase_M14NE-CP-C_like	1040..1115	CDD:200604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900