DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and paplna

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_005169942.1	Gene:	paplna / 562930	ZFINID:	ZDB-GENE-070815-4	Length:	1187	Species:	Danio rerio

Alignment Length:	373	Identity:	80/373 - (21%)
Similarity:	121/373 - (32%)	Gaps:	131/373 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 SSQSQSPSPPAASASA-------SSPSSFS-----------------SFAV-----AHGPQTEAT 190
            :|.:...|.||||.:|       :.||:..                 |.||     ..|...:.|
Zfish   814 ASNAMQQSNPAASWTAEGVSIDKTDPSTVEGLVGQRVVLPCRVTPPPSSAVLVEWRRDGVPVDPT 878

  Fly   191 NHTFKSLAFLDASF--------GSDLF---AQTDAKRE--------------RSGAADEESQDAD 230
            .|..:    ||.|.        .|..|   |..|.||:              .:|.::.:|..:.
Zfish   879 RHEQQ----LDGSLLVGPITLQDSGWFLCVATRDDKRDHRYIYLSVSGSSQNNAGISEVDSSQSY 939

  Fly   231 TSQSLPIFDFGMPRNITGRTGHTEAIIKCR---VDSLHDKSVSWIRKRDLHILTVGTATYTSDKR 292
            ||||...|:......:..|.|.| |.::|.   |.::|..::.|.|               :.:.
Zfish   940 TSQSSSRFNIDYSPLVEARAGQT-AKLQCSVLPVSAIHAVTIHWSR---------------AGQP 988

  Fly   293 FQVTESKDSREWTLHVKAPLAKDSGIYECQVNTEPKM-SMAFQLNIIEISPDAKAVISGPPDLHF 356
            ..........:.||.:|...|.|||:|.|.|....|. ....||.::   .|.: :...|.|:..
Zfish   989 LNSLRHSQHSDGTLVIKQLTADDSGLYTCTVTDAQKFEERQVQLRVL---GDLR-ITKAPIDVDV 1049

  Fly   357 KAGSAIILNCLVQQPSVKDIGPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDIM 421
            ..||...|.|:|...:| ::|   |.|           :|.|..|.|...|   :..|
Zfish  1050 VQGSTAQLACVVTGENV-NVG---WSR-----------NGVPVRPDGHRVH---VSAD------- 1089

  Fly   422 SEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTCQPTTAS 469
                                    ..|.::|.|:.|.|.|||...|.:
Zfish  1090 ------------------------GTLILNNVQSVDEGTYTCNAYTGT 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	20/90 (22%)
		IG_like	243..329	CDD:214653	19/88 (22%)
		Ig	350..464	CDD:299845	24/113 (21%)
		IG_like	<441..477	CDD:214653	9/29 (31%)
paplna	XP_005169942.1	TSP1	24..75	CDD:214559
		ADAM_spacer1	181..293	CDD:310520
		TSP1	303..356	CDD:214559
		TSP1	388..442	CDD:214559
		TSP1	449..498	CDD:214559
		TSP1	504..557	CDD:214559
		KU	720..771	CDD:238057
		Ig_3	839..906	CDD:316449	13/70 (19%)
		IGc2	960..1022	CDD:197706	18/77 (23%)
		I-set	1039..1121	CDD:333254	26/125 (21%)
		PLAC	1142..1173	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900