DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr3 and OPCML

DIOPT Version :9

Sequence 1:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_001306032.1 Gene:OPCML / 4978 HGNCID:8143 Length:354 Species:Homo sapiens


Alignment Length:329 Identity:71/329 - (21%)
Similarity:130/329 - (39%) Gaps:86/329 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 NITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVK 309
            |:|.|.|.: |.::|.:|....: |:|:.:..  ||..|...::.|.|..:..:..: ::::.::
Human    44 NVTVRQGES-ATLRCTIDDRVTR-VAWLNRST--ILYAGNDKWSIDPRVIILVNTPT-QYSIMIQ 103

  Fly   310 APLAKDSGIYECQVNTE--PKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLV---Q 369
            .....|.|.|.|.|.|:  ||.|....  |:::.|....:.|   |:....||::.|.||.   .
Human   104 NVDVYDEGPYTCSVQTDNHPKTSRVHL--IVQVPPQIMNISS---DITVNEGSSVTLLCLAIGRP 163

  Fly   370 QPSVKDIGPIYWYRGEHMITP----FDADDGQPEIPAGR----GEHPQGIPEDTSPNDIMSEVDL 426
            :|:|.      |   .|:...    |.::|...||...:    ||:......|.:..|: .:|.:
Human   164 EPTVT------W---RHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDV-RKVKI 218

  Fly   427 QMEF-----------------------ATRIAM--------ESQL-----GDTLKSRLRIS---- 451
            .:.:                       |:.:.|        |::|     |..::::.|:|    
Human   219 TVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGRMSTLTF 283

  Fly   452 -NAQTTDTGNYTCQPTTA---SSASVLVHVINDEN----PAAM-----QKSGACPCALGPLQLLL 503
             |....|.|||||..|..   ::||:.::.|:..:    |.|:     ..|.|..|......||.
Human   284 FNVSEKDYGNYTCVATNKLGNTNASITLYEISPSSAVAGPGAVIDGVNSASRALACLWLSGTLLA 348

  Fly   504 HLLL 507
            |..:
Human   349 HFFI 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr3NP_001014459.2 Ig 243..330 CDD:299845 22/86 (26%)
IG_like 243..329 CDD:214653 21/85 (25%)
Ig 350..464 CDD:299845 32/165 (19%)
IG_like <441..477 CDD:214653 13/43 (30%)
OPCMLNP_001306032.1 Ig 44..132 CDD:416386 23/94 (24%)
Ig strand A' 44..49 CDD:409353 2/4 (50%)
Ig strand B 51..59 CDD:409353 2/8 (25%)
CDR1 59..63 CDD:409353 1/3 (33%)
FR2 64..70 CDD:409353 2/6 (33%)
Ig strand C 64..70 CDD:409353 2/6 (33%)
CDR2 71..83 CDD:409353 3/13 (23%)
Ig strand C' 72..76 CDD:409353 1/5 (20%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 6/34 (18%)
Ig strand D 87..94 CDD:409353 1/6 (17%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 1/3 (33%)
Ig strand G 123..132 CDD:409353 3/10 (30%)
FR4 125..132 CDD:409353 1/8 (13%)
Ig_3 135..206 CDD:404760 18/82 (22%)
Ig strand A 135..138 CDD:409353 1/2 (50%)
Ig strand A' 144..148 CDD:409353 1/3 (33%)
Ig strand B 151..160 CDD:409353 4/8 (50%)
Ig strand C 165..170 CDD:409353 3/13 (23%)
Ig strand C' 171..174 CDD:409353 1/2 (50%)
Ig strand F 198..206 CDD:409353 2/7 (29%)
Ig 224..312 CDD:416386 17/87 (20%)
putative Ig strand A 224..230 CDD:409353 0/5 (0%)
Ig strand B 240..244 CDD:409353 0/3 (0%)
Ig strand C 253..257 CDD:409353 0/3 (0%)
Ig strand E 279..283 CDD:409353 1/3 (33%)
Ig strand F 293..298 CDD:409353 4/4 (100%)
Ig strand G 306..309 CDD:409353 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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