DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and NCAM2

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	327	Identity:	65/327 - (19%)
Similarity:	109/327 - (33%)	Gaps:	107/327 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DAKRERSGAADEESQDADTSQSLPIFDFGMPRNITG----RTGHTEAIIKCRVDSLHDKSVSWIR 273
            ||...|..|.|.:.|..:.:..|.|:.....|.:..    :.|. :|.:.|||.|....:|||:.
Human   112 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGE-DAEVVCRVSSSPAPAVSWLY 175

  Fly   274 KRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYECQVNTEPKMSMAFQLNII 338
            ..:       ..|..||.||.:..:.:     |.:......|.|||.|:...|.:..:.|:
Human   176 HNE-------EVTTISDNRFAMLANNN-----LQILNINKSDEGIYRCEGRVEARGEIDFR---- 224

  Fly   339 EISPDAKAVISGPPDL-----HFKA----GSAIILNCLVQ---QPSVKDIGPIYWYRGEHMITPF 391
                |...:::.||.:     .|.|    |..:..:|...   :|::.      |:|...:|...
Human   225 ----DIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAIS------WFRNGKLIEEN 279

  Fly   392 DA-----------------DDGQPEI-----PAGRGE---------------------------- 406
            :.                 .||.|.:     .||..|
Human   280 EKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQVT 344

  Fly   407 -----HPQGIPEDTSPNDI----MSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYT 462
                 ..:.|||.|....:    .:|.|..::  .||.::.|.|   .|.|.|.:.:.:|:|.|.
Human   345 LVCDAEGEPIPEITWKRAVDGFTFTEGDKSLD--GRIEVKGQHG---SSSLHIKDVKLSDSGRYD 404

  Fly   463 CQ 464
            |:
Human   405 CE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	22/90 (24%)
		IG_like	243..329	CDD:214653	22/89 (25%)
		Ig	350..464	CDD:299845	32/184 (17%)
		IG_like	<441..477	CDD:214653	8/24 (33%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	7/24 (29%)
		I-set	47..136	CDD:254352	7/23 (30%)
		I-set	142..218	CDD:254352	22/88 (25%)
		IGc2	153..214	CDD:197706	20/73 (27%)
		Ig	233..326	CDD:299845	16/98 (16%)
		I-set	240..323	CDD:254352	14/88 (16%)
		Ig5_NCAM-2	325..422	CDD:143278	17/87 (20%)
		IG_like	333..420	CDD:214653	17/79 (22%)
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900