DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	76/358 - (21%)
Similarity:	127/358 - (35%)	Gaps:	137/358 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DAKRERSGAADEESQDADTSQ--SLPIFDFG------------MPRNITGRTGHTEAIIKCRVDS 263
            ||.|....|.::::.|..|||  :|.:.:.|            .|:|.:...|.:|..::|..::
  Rat   180 DAGRYYVQAVNDKNGDNKTSQPITLAVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTMECVANA 244

  Fly   264 -----LHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYECQV 323
                 ||   :.|  |:|..:|:.|.:.|  ::|..:|.             |:..|:|.|||:.
  Rat   245 RPLIKLH---IVW--KKDGALLSNGISDY--NRRLTITN-------------PMVSDAGYYECEA 289

  Fly   324 NTEPKMSMAFQLNIIEISPDAK----AVISGP-----PDLHFKA--GSAIILNCLVQQPSVKDIG 377
                      .|....::|..:    :|:..|     |:.|..|  ...:.:.|     ..|.:.
  Rat   290 ----------MLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEKVVDIPC-----RAKGVP 339

  Fly   378 P--IYWYRGEHMI-----TPF-DADDGQPEIPAGRGEHPQGIPEDT------------------- 415
            |  |.||:...::     |.| ...||..:| :|.      :|:||
  Rat   340 PPSITWYKDAALVEVGKLTRFKQRSDGGLQI-SGL------LPDDTGMVQCFAHNAAGEAQTSTY 397

  Fly   416 ------SPN-----------DIMSEV-DLQMEFATRIAMESQLGDTL---------------KSR 447
                  :||           |.||.| ..:...|.|.|:..|.|:.:               ...
  Rat   398 LAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTLLESGS 462

  Fly   448 LRISNAQTTDTGNYTCQPTTA-----SSASVLV 475
            |.||....:|.|.|||..|.:     :||.::|
  Rat   463 LLISPTHISDAGTYTCLATNSRGVDEASADLVV 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	21/91 (23%)
		IG_like	243..329	CDD:214653	21/90 (23%)
		Ig	350..464	CDD:299845	37/180 (21%)
		IG_like	<441..477	CDD:214653	13/55 (24%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653	9/25 (36%)
		Ig	135..191	CDD:299845	4/10 (40%)
		IG_like	225..307	CDD:214653	22/111 (20%)
		IGc2	236..289	CDD:197706	17/72 (24%)
		I-set	311..400	CDD:254352	19/100 (19%)
		Ig	329..397	CDD:143165	15/79 (19%)
		I-set	405..495	CDD:254352	22/89 (25%)
		Ig	419..495	CDD:299845	19/75 (25%)
		Ig	505..589	CDD:299845
		IG_like	505..589	CDD:214653
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810