DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and Dscam4

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	99/558 - (17%)
Similarity:	158/558 - (28%)	Gaps:	218/558 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 QPDDSGDGPTLSTFLSSSQSQSPSPPAASASASSPSS---FSSFAVAHGPQTE----ATNHTFKS 196
            |.:|.|   ....|:|:...|..|........:||..   ||...:..||...    ||.:....
  Fly   391 QKEDPG---MYQCFVSNEWEQIQSTAELQLGDASPELLYWFSEQTLQPGPTVSLKCVATGNPLPQ 452

  Fly   197 LAF-LD---------------ASFGSDLFAQ---TDAKRERSGAADEESQDA--DTSQSLPIFDF 240
            ..: ||               .:...|:.:.   ::.|.|..|.....:|:|  ..|.|..:..:
  Fly   453 FTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIY 517

  Fly   241 GMP-----RNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKD 300
            |:|     ..|||.:| ::.|:||.|.......:.|  :||...|.:.......:....:.|...
  Fly   518 GLPYIREMPKITGISG-SDLIVKCPVAGYPIDKIHW--ERDGQTLPINRRQRAYNNGTLIIEQLQ 579

  Fly   301 SREWTLHVKAPLAKDSGIYEC----------------QVNTEPK--------------MSMAFQL 335
            ..|           |:|.|.|                ||...||              |..|...
  Fly   580 RLE-----------DAGTYTCMAQNKQKQTSRRNVEIQVLVPPKIMPIQAMTNMLREGMRAAISC 633

  Fly   336 NIIE--------------------------------------ISPD------------------- 343
            .|:|                                      ||.|
  Fly   634 QILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFT 698

  Fly   344 AKAVISGPP-------DLHFKAGSAIILNCL---VQQPSV---KDIGPI------YWYRGEHMIT 389
            ....::.||       |...:||:.::|:|.   ...|::   |.|||.      :.|.....:.
  Fly   699 VPLTVNVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQLF 763

  Fly   390 P------------------------------------------FDADDGQPEIPAGRGEHPQGIP 412
            |                                          |.....|..:..|:..|.|...
  Fly   764 PNGTIFFKKISKESQGHFLCEAKNNIGSGVSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNV 828

  Fly   413 EDTSPNDIMSEVDLQMEFA-----TRIAMESQ-LGDTLKSRLRISNAQTTDTGNYTCQPTTA--- 468
            :..:|.|...::....::.     :|..:..| |.|.:.|.|.||:....|||.|.||.:.|
  Fly   829 QGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQASNAFGQ 893

  Fly   469 --SSASVLVHV---------INDENPAAMQKSGACPCA 495
              .|..::|..         ||.:...::|.:.:.|.|
  Fly   894 DEMSIQLIVQEVPEQPKNLRINSQQSRSLQLTWSQPFA 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	23/121 (19%)
		IG_like	243..329	CDD:214653	23/120 (19%)
		Ig	350..464	CDD:299845	33/180 (18%)
		IG_like	<441..477	CDD:214653	14/40 (35%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386
		Ig strand A	235..238	CDD:409353
		Ig strand A'	244..248	CDD:409353
		Ig strand B	251..258	CDD:409353
		Ig strand C	266..271	CDD:409353
		Ig strand C'	276..279	CDD:409353
		Ig strand D	285..289	CDD:409353
		Ig strand E	292..298	CDD:409353
		Ig strand F	305..313	CDD:409353
		Ig strand G	316..326	CDD:409353
		IgC2_3_Dscam	329..417	CDD:409549	7/28 (25%)
		Ig strand B	347..351	CDD:409549
		Ig strand C	360..364	CDD:409549
		Ig strand E	383..387	CDD:409549
		Ig strand F	397..402	CDD:409549	0/4 (0%)
		Ig strand G	410..413	CDD:409549	1/2 (50%)
		IgI_4_Dscam	422..516	CDD:409548	17/93 (18%)
		Ig strand B	439..443	CDD:409548	0/3 (0%)
		Ig strand C	452..456	CDD:409548	0/3 (0%)
		Ig strand E	482..486	CDD:409548	0/3 (0%)
		Ig strand F	496..501	CDD:409548	0/4 (0%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	19/100 (19%)
		Ig strand B	536..540	CDD:409550	1/3 (33%)
		Ig strand C	549..553	CDD:409550	1/5 (20%)
		Ig strand E	571..575	CDD:409550	0/3 (0%)
		Ig strand F	586..591	CDD:409550	2/4 (50%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	9/92 (10%)
		Ig strand A	611..613	CDD:409353	1/1 (100%)
		Ig strand A'	620..624	CDD:409353	0/3 (0%)
		Ig strand B	627..636	CDD:409353	2/8 (25%)
		Ig strand C	641..648	CDD:409353	0/6 (0%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	0/6 (0%)
		Ig strand F	682..690	CDD:409353	0/7 (0%)
		Ig strand G	693..702	CDD:409353	0/8 (0%)
		IgI_7_Dscam	706..801	CDD:409546	14/94 (15%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	0/3 (0%)
		Ig strand F	780..785	CDD:409546	0/4 (0%)
		Ig strand G	794..797	CDD:409546	0/2 (0%)
		Ig	818..904	CDD:416386	22/85 (26%)
		putative Ig strand B	820..827	CDD:409353	2/6 (33%)
		putative Ig strand C	835..841	CDD:409353	1/5 (20%)
		putative Ig strand C'	853..856	CDD:409353	1/2 (50%)
		putative Ig strand D	862..866	CDD:409353	2/3 (67%)
		putative Ig strand E	868..874	CDD:409353	3/5 (60%)
		putative Ig strand F	881..889	CDD:409353	4/7 (57%)
		putative Ig strand G	892..902	CDD:409353	1/9 (11%)
		FN3	906..999	CDD:238020	5/26 (19%)
		FN3	1006..1110	CDD:238020
		fn3	1117..1203	CDD:394996
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900