Protein Alignment dpr3 and NEGR1

DIOPT Version :10

• Sequence 1: NP_001014459.2
• Gene: dpr3 / 3346208
• FlyBaseID: FBgn0053516
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_776169.2
• Gene: NEGR1 / 257194
• HGNCID: 17302
• Length: 354
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 64/308 - (20%)
• Similarity: 114/308 - (37%)
• Gaps: 89/308 - (28%)

  Fly   238 FDFGMPRNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSR 302
            |.:....|:..|.|.| |:::|.::....|. :|:.:..  |:..|...::.|.|..:: :.:.|
Human    40 FPWAAVDNMMVRKGDT-AVLRCYLEDGASKG-AWLNRSS--IIFAGGDKWSVDPRVSIS-TLNKR 99

  Fly   303 EWTLHVKAPLAKDSGIYECQVNTE--PKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILN 365
            :::|.::.....|.|.|.|.|.|:  |: :|...|. :::.|....:.:   |:....|:.:.|.
Human   100 DYSLQIQNVDVTDDGPYTCSVQTQHTPR-TMQVHLT-VQVPPKIYDISN---DMTVNEGTNVTLT 159

  Fly   366 CLV---QQPSVKDIGPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDI----MSE 423
            ||.   .:||:.      |........||  ::||.....|......|..|.::.||:    :.:
Human   160 CLATGKPEPSIS------WRHISPSAKPF--ENGQYLDIYGITRDQAGEYECSAENDVSFPDVRK 216

  Fly   424 VDLQMEFATRI--------------------------AMESQLGD---------------TLKSR 447
            |.:.:.||..|                          |.|...|:               :.:|.
Human   217 VKVVVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFSTRSI 281

  Fly   448 LRISNAQTTDTGNYTC----------------QPTTA-----SSASVL 474
            |.::|......|||||                .|:||     .||.||
Human   282 LTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADVL 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	IG_like	243..329	CDD:214653	21/87 (24%)
		Ig strand B	255..259	CDD:409353	1/3 (33%)
		Ig strand C	269..272	CDD:409353	0/2 (0%)
		Ig strand E	304..308	CDD:409353	1/3 (33%)
		Ig strand F	318..323	CDD:409353	2/4 (50%)
		IG_like	<441..477	CDD:214653	16/70 (23%)
NEGR1	NP_776169.2	IG_like	47..135	CDD:214653	23/94 (24%)
		Ig strand B	56..60	CDD:409353	1/3 (33%)
		Ig strand C	68..72	CDD:409353	1/4 (25%)
		Ig strand E	101..105	CDD:409353	1/3 (33%)
		Ig strand F	115..120	CDD:409353	2/4 (50%)
		Ig strand G	128..131	CDD:409353	1/2 (50%)
		Ig_3	138..207	CDD:464046	16/79 (20%)
		IG_like	231..312	CDD:214653	11/80 (14%)
		Ig strand B	241..245	CDD:409353	0/3 (0%)
		Ig strand C	254..258	CDD:409353	2/3 (67%)
		Ig strand E	280..284	CDD:409353	2/3 (67%)
		Ig strand F	294..299	CDD:409353	4/4 (100%)