DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	234	Identity:	49/234 - (20%)
Similarity:	84/234 - (35%)	Gaps:	68/234 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 TGHTEAI--IKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPL 312
            |...|.:  |.||...:...|::|.  :|..::.||          ::|..|...:..|.:...|
Mouse   323 TAEMEKVVDIPCRAKGVPPPSITWY--KDAALVEVG----------KLTRFKQRSDGGLQISGLL 375

  Fly   313 AKDSGIYECQV-NTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLVQQPSVKDI 376
            ..|:|:.:|.. |...:...:..|.:..|:|:   :..||.|.....|.:::|.|   :.|....
Mouse   376 PDDTGMLQCFAHNAAGEAQTSTYLAVTSIAPN---ITRGPLDSTVIDGMSVVLAC---ETSGAPR 434

  Fly   377 GPIYWYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPNDIMSEVDLQMEFATRIAMESQLG 441
            ..|.|.:||.::.     .|..::|                           .|.   .:||
Mouse   435 PAITWQKGERILA-----SGSVQLP---------------------------RFT---LLES--- 461

  Fly   442 DTLKSRLRISNAQTTDTGNYTCQPTTA-----SSASVLV 475
                ..|.||....:|.|.|||..|.:     :||.::|
Mouse   462 ----GSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	18/82 (22%)
		IG_like	243..329	CDD:214653	18/81 (22%)
		Ig	350..464	CDD:299845	23/113 (20%)
		IG_like	<441..477	CDD:214653	12/40 (30%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653
		Ig	136..192	CDD:299845
		IG_like	226..308	CDD:214653
		IGc2	237..290	CDD:197706
		I-set	312..401	CDD:254352	19/89 (21%)
		Ig	330..398	CDD:143165	16/79 (20%)
		I-set	406..496	CDD:254352	28/137 (20%)
		Ig	420..496	CDD:299845	24/120 (20%)
		Ig	506..590	CDD:299845
		IG_like	506..590	CDD:214653
		FN3	594..685	CDD:238020
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810