DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr3 and Sirpa

DIOPT Version :10

Sequence 1:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_001277948.1 Gene:Sirpa / 19261 MGIID:108563 Length:513 Species:Mus musculus


Alignment Length:140 Identity:36/140 - (25%)
Similarity:54/140 - (38%) Gaps:49/140 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 AGSAIILNCLVQQPSVKDIGPIYWYRG----EHMITPFDADDGQPEIPAGRGEHPQGIPEDTSPN 418
            ||.:.:|||.:  .|:..:|||.||||    ..:|..| |.:..|.|        :.:.:.|..|
Mouse    47 AGDSTVLNCTL--TSLLPVGPIRWYRGVGPSRLLIYSF-AGEYVPRI--------RNVSDTTKRN 100

  Fly   419 DIMSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTC--------QPTT--ASSASV 473
            :        |:|:                :||||....|.|.|.|        :|.|  .|....
Mouse   101 N--------MDFS----------------IRISNVTPADAGIYYCVKFQKGSSEPDTEIQSGGGT 141

  Fly   474 LVHVINDENP 483
            .|:|:...:|
Mouse   142 EVYVLAKPSP 151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr3NP_001014459.2 IG_like 243..329 CDD:214653
Ig strand B 255..259 CDD:409353
Ig strand C 269..272 CDD:409353
Ig strand E 304..308 CDD:409353
Ig strand F 318..323 CDD:409353
IG_like <441..477 CDD:214653 12/45 (27%)
SirpaNP_001277948.1 Ig 35..146 CDD:472250 34/133 (26%)
Ig strand B 51..55 CDD:409516 1/3 (33%)
Ig strand C 65..69 CDD:409516 2/3 (67%)
Ig strand E 104..108 CDD:409516 1/19 (5%)
Ig strand F 118..123 CDD:409516 2/4 (50%)
Ig strand G 138..141 CDD:409516 0/2 (0%)
IgC1_SIRP_domain_2 148..250 CDD:409429 1/4 (25%)
Ig strand A 152..156 CDD:409429 36/140 (26%)
Ig strand B 166..174 CDD:409429
Ig strand C 180..186 CDD:409429
Ig strand C' 189..192 CDD:409429
Ig strand D 195..202 CDD:409429
Ig strand E 208..217 CDD:409429
Ig strand F 225..233 CDD:409429
Ig strand G 240..246 CDD:409429
IgC1_SIRP_domain_3 253..348 CDD:409507
Ig strand A 254..262 CDD:409507
Ig strand B 270..277 CDD:409507
Ig strand C 283..289 CDD:409507
Ig strand C' 292..295 CDD:409507
Ig strand D 300..306 CDD:409507
Ig strand E 310..320 CDD:409507
Ig strand F 329..336 CDD:409507
Ig strand G 342..346 CDD:409507
SH2-binding. /evidence=ECO:0000255 440..443
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..513
SH3-binding. /evidence=ECO:0000255 450..455
SH2-binding. /evidence=ECO:0000255 464..467
SH2-binding. /evidence=ECO:0000255 481..484
SH2-binding. /evidence=ECO:0000255 505..508
Blue background indicates that the domain is not in the aligned region.

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