DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr3 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	324	Identity:	68/324 - (20%)
Similarity:	109/324 - (33%)	Gaps:	101/324 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DAKRERSGAADEESQDADTSQSLPIFDFGMPRNITG----RTGHTEAIIKCRVDSLHDKSVSWIR 273
            ||...|..|.|.:.|..:.:..|.|:.....|.:..    :.|. :|.:.|||.|....:|||:.
Mouse    87 DAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGE-DAEVVCRVSSSPAPAVSWLY 150

  Fly   274 KRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYECQVNTEPKMSMAFQ--LN 336
            ..:       ..|...|.||.|..:.:     |.:......|.|||.|:...|.:..:.|:  :.
Mouse   151 HNE-------EVTTIPDNRFAVLANNN-----LQILNINKSDEGIYRCEGRVEARGEIDFRDIIV 203

  Fly   337 IIEISPDAKAVISGPPDLHFKA----GSAIILNCLVQ---QPSVKDIGPIYWYRGEHMITP---- 390
            |:.:.|   |::.  |...|.|    |..:.|.|...   .|::.      |:|...:|..
Mouse   204 IVNVPP---AIMM--PQKSFNATAERGEEMTLTCKASGSPDPTIS------WFRNGKLIEENEKY 257

  Fly   391 --------------FDADDG-----------------------QPEIPAGRGE------------ 406
                          .:.|.|                       ||.|...:.|
Mouse   258 ILKGSNTELTVRNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLVC 322

  Fly   407 --HPQGIPEDTSPNDI----MSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTCQ 464
              ..:.:||.|....|    .||.|...:  .||.::.|.|   :|.|.|.:.:.:|:|.|.|:
Mouse   323 EAEGEPVPEITWKRAIDGVMFSEGDKSPD--GRIEVKGQHG---RSSLHIRDVKLSDSGRYDCE 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	22/90 (24%)
		IG_like	243..329	CDD:214653	22/89 (25%)
		Ig	350..464	CDD:299845	33/179 (18%)
		IG_like	<441..477	CDD:214653	8/24 (33%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274	7/24 (29%)
		I-set	22..111	CDD:254352	7/23 (30%)
		I-set	117..193	CDD:254352	22/88 (25%)
		IGc2	128..189	CDD:197706	20/73 (27%)
		Ig	208..301	CDD:299845	14/103 (14%)
		I-set	215..298	CDD:254352	11/88 (13%)
		Ig	300..397	CDD:299845	22/87 (25%)
		IG_like	308..395	CDD:214653	19/79 (24%)
		IG_like	413..491	CDD:214653
		IGc2	414..482	CDD:197706
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900