DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33543 and PAPLN

DIOPT Version :9

Sequence 1:NP_001014458.3 Gene:CG33543 / 3346207 FlyBaseID:FBgn0053543 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens


Alignment Length:378 Identity:80/378 - (21%)
Similarity:128/378 - (33%) Gaps:82/378 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QLDSTSSGGSGTGG--APPDRPPTPPLSLQPSTPSITHFVNESFI-IFC-QTVQKDIDTKWRDPR 84
            :|.|.:.|..|..|  |||....:..:||....||:........: :.| .....:....|:.. 
Human   883 ELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLVRLSCSDDTAPESQAAWQKD- 946

  Fly    85 GQTRENTKGRVHIEKKTTGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFL-ASFELLV 148
            ||...:.:.|:..:.      :|:...:..||.|.::|  ...|.|..:..::...: ....:|.
Human   947 GQPISSDRHRLQFDG------SLIIHPLQAEDAGTYSC--GSTRPGRDSQKIQLRIIGGDMAVLS 1003

  Fly   149 NQKIS-----------FGKT--------------------------EQVQSVREGRDAMVNCFVE 176
            ..::|           ||:.                          .:|.....|:...:.|..|
Human  1004 EAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAE 1068

  Fly   177 GMPAPEVSWLYNGEYINTVNSTKHNRLSNG-LYIRNVSQADAGEYTCRAMRITPTFSDSDQITIL 240
            |.|.|.:.|..:|:   .|:|.:|....:| |.|..|:..|.|.|||.|.    ...|.||..:.
Human  1069 GFPPPAIEWQRDGQ---PVSSPRHQLQPDGSLVISRVAVEDGGFYTCVAF----NGQDRDQRWVQ 1126

  Fly   241 LRIQHK-------PHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVGFNHRIFV 298
            ||:..:       |    ..|:|     .|....|.|...|| ..:..|..|...:....||:..
Human  1127 LRVLGELTISGLPP----TVTVP-----EGDTARLLCVVAGE-SVNIRWSRNGLPVQADGHRVHQ 1181

  Fly   299 ADYGATLQLQMKNASQFGDYKCKVANPLGMLER-----VIKLRPGPKPLGPRR 346
            :..| ||.:....|...|.|.|........:.|     |:...|..:|..|.|
Human  1182 SPDG-TLLIYNLRARDEGSYTCSAYQGSQAVSRSTEVKVVSPAPTAQPRDPGR 1233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33543NP_001014458.3 IGc2 165..224 CDD:197706 20/59 (34%)
IG_like 256..336 CDD:214653 19/84 (23%)
IGc2 263..327 CDD:197706 16/63 (25%)
FN3 341..445 CDD:238020 3/6 (50%)
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559
ADAM_spacer1 183..298 CDD:310520
TSP1 308..361 CDD:214559
TSP1 369..424 CDD:214559
TSP1 424..481 CDD:214559
TSP1 488..539 CDD:214559
Kunitz_BPTI 753..805 CDD:278443
Papilin_u7 814..905 CDD:318767 8/21 (38%)
Ig 914..>978 CDD:325142 11/70 (16%)
I-set 1049..1119 CDD:254352 22/76 (29%)
IG 1139..1219 CDD:214652 20/90 (22%)
PLAC 1235..1267 CDD:312271
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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