DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	312	Identity:	75/312 - (24%)
Similarity:	120/312 - (38%)	Gaps:	63/312 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPTPPLSLQPSTPSITHFVNESFIIF-CQTVQKDIDTKWR-DPRGQTRENTKGRVHIEKKTTGLL 105
            ||...||::|..     .:.::.:.| |........|::| ..|||..:...|.|:   :||...
Human   255 PPLVNLSVEPQP-----VLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVY---RTTVDY 311

  Fly   106 ALVFEHIALEDRGNWTCEVN---GNRNGNRNVNVEREFLASFELLVNQKISFG--KTEQVQS--V 163
            ....|.:        :|||.   |:.|.:|.|:|                .||  .|.:.||  |
Human   312 TYFSEPV--------SCEVTNALGSTNLSRTVDV----------------YFGPRMTTEPQSLLV 352

  Fly   164 REGRDAMVNCFVEGMPAPEVSWLYNGEYINTVNSTKHNRLSNGLYIRNVSQADAGEYTCRAMRIT 228
            ..|.||:.:|...|.|:..:.|:..|..:...|       ...|.:::|.|.|||:|.|||  :.
Human   353 DLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSN-------EKTLTLKSVRQEDAGKYVCRA--VV 408

  Fly   229 PTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPP---SFTWLHN--NKG 288
            |.....:: .:.|.:...|.....:|   |:|..|....:.|.....|||   :::|..|  ..|
Human   409 PRVGAGER-EVTLTVNGPPIISSTQT---QHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESG 469

  Fly   289 IVG-FNHRIFVADYGATLQLQMKN--ASQFGD-YKCKVANPLGMLERVIKLR 336
            ..| :.......:.|....|.:.|  .:.|.. |.|...|..|....:|:|:
Human   470 TSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLK 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	17/58 (29%)
		IG_like	256..336	CDD:214653	20/88 (23%)
		IGc2	263..327	CDD:197706	16/72 (22%)
		FN3	341..445	CDD:238020
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352
		Ig2_KIRREL3-like	171..252	CDD:143236
		Ig_2	260..337	CDD:290606	22/92 (24%)
		I-set	341..422	CDD:254352	25/90 (28%)
		IGc2	355..406	CDD:197706	17/57 (30%)
		Ig5_KIRREL3	424..521	CDD:143306	22/99 (22%)
		IG_like	432..521	CDD:214653	21/91 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900