DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and zgc:152904

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001070212.1	Gene:	zgc:152904 / 767777	ZFINID:	ZDB-GENE-060929-856	Length:	809	Species:	Danio rerio

Alignment Length:	424	Identity:	107/424 - (25%)
Similarity:	172/424 - (40%)	Gaps:	64/424 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PPLSLQPSTPSITHFVNESFIIFCQTV-QKDIDTKWRDPRGQTRENTKGRVHIEKKTTGLLALVF 109
            |.||:...:.:.|....||....|.|. ..|....|. .:|...|:::..| :.....|...|..
Zfish   178 PVLSVPQQSFNATADYQESVTFTCVTSGSPDPQVTWY-WKGHAIEHSEQYV-LNTMNGGKSTLTV 240

  Fly   110 EHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVR--EGRDAMVN 172
            ::|...|.|.:.|..: |:.|:....:   ||..|   |...|:     |:::|.  ||..||::
Zfish   241 KNIKQTDGGPYMCRAS-NKAGSSESQL---FLKVF---VQPHIT-----QLRNVTAVEGSAAMIS 293

  Fly   173 CFVEGMPAPEVSW--LYNGEYINTVNSTKHNRL-------SNGLYIRNVSQADAGEYTCRAM-RI 227
            |..||.|.||:||  ..:|........:|..|:       .:.|.|..|..:|.|.:.|.|: ||
Zfish   294 CTAEGEPLPEISWRRASDGHSFTDGEKSKDGRVEVRGRHGKSMLTISGVQLSDWGRFDCEALSRI 358

  Fly   228 TPTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVG- 291
                 ...|.::.|.|::.|.:..|::  :.|::.|..||:||:....|..:..|......|..
Zfish   359 -----GGHQKSMFLDIEYAPKFQTNQS--IFYSWEGNPVNISCEVKSNPAATMLWRRERFTISSQ 416

  Fly   292 --FNHRIFVADYGATLQLQMKNASQFGDYKCKVANPLGMLERVIKLRPGPKPLGPRRFQLKKLYT 354
              .|.||...|..:.|::...:...||.|.|...|.:|...:...|.....|..|...::..:
Zfish   417 GTSNIRIHSTDGRSLLEVTPVSDRDFGRYNCTARNNIGARYQEFILAQADVPSSPYSVRMTAV-- 479

  Fly   355 NGFELDIQTPRMSNVS-------DEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGK-HF 411
                    :.||:.||       ..:.|..|.:.| .||.   ||..|..|:.     ||.: ..
Zfish   480 --------SQRMATVSFMKPDSHGGVPISFYIINY-RDTS---SAQEWRSART-----HGVQTAV 527

  Fly   412 IIPHLETNTTYLMRAASRNLAGLSDWSPVKVFTT 445
            ::..||.||||.:|.::.|..|..::|..:.|.|
Zfish   528 VLTSLEPNTTYEVRVSAVNGKGQGEFSHTESFQT 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	21/67 (31%)
		IG_like	256..336	CDD:214653	20/82 (24%)
		IGc2	263..327	CDD:197706	18/66 (27%)
		FN3	341..445	CDD:238020	28/111 (25%)
zgc:152904	NP_001070212.1	Ig	1..81	CDD:299845
		IG_like	2..80	CDD:214653
		IGc2	97..158	CDD:197706
		Ig	177..273	CDD:299845	24/103 (23%)
		I-set	184..270	CDD:254352	20/91 (22%)
		Ig	272..369	CDD:299845	30/106 (28%)
		I-set	274..367	CDD:254352	28/102 (27%)
		IG_like	385..462	CDD:214653	19/76 (25%)
		IGc2	386..454	CDD:197706	18/67 (27%)
		FN3	468..561	CDD:238020	28/111 (25%)
		fn3	<591..650	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010