DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and USH2A

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens

Alignment Length:	637	Identity:	127/637 - (19%)
Similarity:	180/637 - (28%)	Gaps:	258/637 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LDSTSSGGSGTGGAPPDRPPTPPLSLQ--PS--TPSITHFVNESFIIFCQTVQKDIDTKWRDPRG 85
            |.:.:|||..|.      .||...:|:  ||  :|.....|:.:.:..|          |..|..
Human  4333 LQACTSGGCSTS------KPTSITTLEAAPSEVSPPDLWAVSATQMNVC----------WSPPTV 4381

  Fly    86 QTRENTKGRVHIEKKTT----GLLALV----------FEHIALEDRG--------NWTCE----- 123
            |..:.||..|..:.|.:    ||..||          |..:|..:.|        .||.|
Human  4382 QNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPEN 4446

  Fly   124 -------VNG------------NRNGN-RNVNVEREFLASFELLVNQKISFGKTEQVQ------- 161
                   |.|            |.||. |:..:.|:....:..|..:...|..|..|:
Human  4447 MDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTA 4511

  Fly   162 SVREG-------RDAMVNCFVEGMPAPE----------VSW----LYNGEYIN------------ 193
            |..:|       :|........||..|:          |:|    ..||:.||
Human  4512 SNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERE 4576

  Fly   194 ----TVNSTKHNRLSNGLYIRNVSQADAGEYTCRAMRITP--------TFSDSDQITILLRIQHK 246
                .:|:| ||......||.| .......|..|....|.        ||..:.:|..|:  |..
Human  4577 TKIIHINTT-HNSFGMQSYIVN-QLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLM--QPP 4637

  Fly   247 PH-----------------W-------------------------------FFN---------ET 254
            ||                 |                               .:|         |.
Human  4638 PHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSEL 4702

  Fly   255 LP-VQYAYVGGAVNLSCDAMGEPPPSFTWLHNN------------------------------KG 288
            || .:|.|...|||    :.|:.|.|:||....                              .|
Human  4703 LPFTEYEYQVWAVN----SAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNG 4763

  Fly   289 IVGFNHRIF---------VADYGATLQLQMKNASQFGDY----------KCKVANPLGMLERVIK 334
            ||.. :|:|         |...|...|..:.....|.:|          .|....|...|    :
Human  4764 IVSL-YRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAEL----R 4823

  Fly   335 LRPGPKPLGPRRFQLKKLYTNGFELDIQTPRMSN---VSDEMQIYGYRVAYMSDTEFKFSAGNWS 396
            ..|.| |.|....|:..|.:.........|...|   .|.|:|   :.||...|:....:
Human  4824 THPAP-PSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQ---FHVACPPDSALPCT----- 4879

  Fly   397 YAKQRDFSFHG-GKHFIIPHLETNTTYLMRAASRNLAG--LSDWSPVKVFTT 445
             ..|.:..:.| |:...:..|:..|||.:|..:.|..|  .|:|..   |||
Human  4880 -PSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWIS---FTT 4927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	19/95 (20%)
		IG_like	256..336	CDD:214653	24/129 (19%)
		IGc2	263..327	CDD:197706	20/112 (18%)
		FN3	341..445	CDD:238020	25/109 (23%)
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058
		FN3	1956..2051	CDD:238020
		FN3	2241..2313	CDD:238020
		FN3	2329..2428	CDD:238020
		FN3	2432..2528	CDD:238020
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020
		FN3	2925..3015	CDD:238020
		FN3	3026..>3087	CDD:238020
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020	7/23 (30%)
		fn3	4357..4428	CDD:394996	17/80 (21%)
		FN3	4444..4516	CDD:238020	12/71 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541		4/22 (18%)
		FN3	4529..4627	CDD:238020	21/99 (21%)
		FN3	4636..4730	CDD:238020	17/97 (18%)
		FN3	4826..4927	CDD:238020	27/113 (24%)
		PDZ-binding	5200..5202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900