DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and ush2a

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_009291422.1	Gene:	ush2a / 568982	ZFINID:	ZDB-GENE-060503-794	Length:	5243	Species:	Danio rerio

Alignment Length:	512	Identity:	97/512 - (18%)
Similarity:	163/512 - (31%)	Gaps:	200/512 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PPLSLQPSTPSITHF---VNESFIIFCQTVQKDIDTKWRDPRGQTRENTKGRVHIEKKTTGLLAL 107
            ||..|.|  ||::|.   .||.|:.:         |...:|.|...     ...|::...|.
Zfish  4288 PPRGLAP--PSVSHIEGKPNEVFVAW---------TPPLEPNGVLL-----TYRIQRDNIGF--- 4333

  Fly   108 VFEHIALEDR-GNWTCEVNGNRNGNRNVNVEREFLASFELL---VNQKISFGKTEQVQSVREGRD 168
               |.:.:.. .|:|           :|::....|.|:.::   |...::.|.| |:::
Zfish  4334 ---HFSFDSSVFNYT-----------DVDLNAYTLYSYAIIACTVAGCVTSGPT-QIRT------ 4377

  Fly   169 AMVNCFVEGMPAPEVSWLYNGEYINTVNSTKHNRLSNGLYIRNVSQADAGEYTCRAMRITPTFSD 233
                  :||.||             ||:|...:.:::  |..|||..            .|:|.:
Zfish  4378 ------LEGAPA-------------TVDSPILSDITS--YSLNVSWT------------VPSFQN 4409

  Fly   234 SDQITILLRIQH----------------KPHWFFNETLPVQYAYV------GGAVNLS------- 269
            .:.:..:|::.:                :||        |.|:.:      ||..:.|
Zfish  4410 GEIVVYILKVNNDEVYRGKRLSVQVLDLQPH--------VSYSIILTACTNGGCTSSSPILIQTR 4466

  Fly   270 -CDAMGEPPPSF----------TW---LHNNKGIVGFNHRIFVADYGATLQLQMKNAS------- 313
             ....|.|.|:.          ||   :|.|..|:|:..|              :|.|
Zfish  4467 EAPPSGMPAPTLKVTGPESVEVTWREPVHPNGVIMGYELR--------------RNGSLIYTGTD 4517

  Fly   314 -QFGD----------YKCKVANPLGML---ERVIKLRP-GPKPLGPRRFQLKKLYTNGFELDIQT 363
             ::.|          |.....|..|..   ..|.:.:| .|..:.|.|.|....::...:.| ..
Zfish  4518 TRYHDFTLLPSVEYSYTITANNSEGATTSPPAVARTQPSAPSGVAPPRLQALGPFSVMVKWD-PP 4581

  Fly   364 PRMSNVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGKHFIIPHLETNTTYLMRAAS 428
            .|.:.|.....:|....|..:...|.| |.:.|..:.|.||.:..|.:.        .|.:|..:
Zfish  4582 ARPNGVIISYSLYKRDPAENNVKRFVF-ASHHSAFQSRSFSLNTLKPYY--------RYEVRVEA 4637

  Fly   429 RNLAG--LSDWSPVKVF---------------TTAAG------CSWSPWLYPSYGLI 462
            .:|.|  .||||.::..               |...|      .||||...|:..|:
Zfish  4638 CSLLGCAASDWSSIQTLESPPAGQPAPLLELQTNPKGLQTVFLLSWSPPTEPNGKLL 4694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	11/58 (19%)
		IG_like	256..336	CDD:214653	22/127 (17%)
		IGc2	263..327	CDD:197706	18/102 (18%)
		FN3	341..445	CDD:238020	24/120 (20%)
ush2a	XP_009291422.1	Laminin_G_3	160..297	CDD:290121
		Laminin_N	307..528	CDD:295486
		EGF_Lam	529..577	CDD:238012
		EGF_Lam	586..638	CDD:238012
		Laminin_EGF	653..703	CDD:278482
		Laminin_EGF	706..756	CDD:278482
		EGF_Lam	759..797	CDD:214543
		Laminin_EGF	808..857	CDD:278482
		EGF_Lam	859..912	CDD:238012
		EGF_Lam	913..963	CDD:238012
		EGF_Lam	965..1014	CDD:238012
		EGF_Lam	1015..1064	CDD:238012
		FN3	1177..1253	CDD:238020
		FN3	1264..1375	CDD:238020
		FN3	1386..1469	CDD:214495
		LamG	1537..1699	CDD:238058
		LamG	1737..1890	CDD:238058
		FN3	1981..2071	CDD:238020
		FN3	2163..2253	CDD:238020
		FN3	2258..2341	CDD:238020
		FN3	2352..2443	CDD:238020
		FN3	2447..2544	CDD:238020
		FN3	2547..2633	CDD:238020
		FN3	2635..2733	CDD:238020
		FN3	2743..2807	CDD:238020
		FN3	2830..2932	CDD:238020
		fn3	2939..3014	CDD:278470
		FN3	3032..>3099	CDD:238020
		FN3	3542..3611	CDD:238020
		FN3	3615..3701	CDD:238020
		fn3	3718..3784	CDD:278470
		FN3	3801..3887	CDD:238020
		FN3	3908..3971	CDD:238020
		FN3	3996..4086	CDD:238020
		FN3	4186..4284	CDD:238020
		fn3	4288..4366	CDD:278470	22/110 (20%)
		FN3	4382..4465	CDD:238020	19/117 (16%)
		FN3	4470..4553	CDD:238020	17/96 (18%)
		FN3	4555..4653	CDD:238020	26/107 (24%)
		FN3	4679..4753	CDD:238020	6/16 (38%)
		fn3	4760..4830	CDD:278470
		FN3	4864..4955	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900