DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33543 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	320	Identity:	79/320 - (24%)
Similarity:	120/320 - (37%)	Gaps:	65/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPTPPLSLQPSTPSITHFVNESFIIFCQ-TVQKDI-DTKWRDPRGQTRENTKGRVHIEK------ 99
            |||..||::|.|..    ..|..:..|| |...:| ..:|          .||...||.
Human   222 PPTVTLSIEPQTVQ----EGERVVFTCQATANPEILGYRW----------AKGGFLIEDAHESRY 272

  Fly   100 KTTGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVR 164
            :|....:...|.:        :|||: |:.|:.||:.......:..::|:.|.:   |..:
Human   273 ETNVDYSFFTEPV--------SCEVH-NKVGSTNVSTLVNVHFAPRIVVDPKPT---TTDI---- 321

  Fly   165 EGRDAMVNCFVEGMPAPEVSWLYN---------GEYINTVNSTKHNRLSNGLYIRNVSQADAGEY 220
             |.|..:.|...|.|...::|...         |.......|.:....||.|.:::|:|||||.|
Human   322 -GSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAALSAQVLSNSNQLLLKSVTQADAGTY 385

  Fly   221 TCRAMRITPTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPP---SFTW 282
            ||||  |.|....::: .:.|.:...|   ...:..||||..|....:.|.....|||   ::.|
Human   386 TCRA--IVPRIGVAER-EVPLYVNGPP---IISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAW 444

  Fly   283 LHNNKGIVGFNHRIFV----ADYGATLQLQMKNASQFG---DYKCKVANPLGMLERVIKL 335
            ..|... ||...|..|    :..|....|.:.|..:..   .|.|...|..|....:|:|
Human   445 KENFLE-VGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	20/67 (30%)
		IG_like	256..336	CDD:214653	24/90 (27%)
		IGc2	263..327	CDD:197706	17/73 (23%)
		FN3	341..445	CDD:238020
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352
		Ig	25..116	CDD:299845
		Ig2_KIRREL3-like	138..219	CDD:143236
		I-set	223..304	CDD:254352	25/103 (24%)
		Ig_2	227..305	CDD:290606	23/100 (23%)
		Ig_2	311..405	CDD:290606	28/104 (27%)
		IG_like	314..405	CDD:214653	27/101 (27%)
		Ig5_KIRREL3	407..504	CDD:143306	25/101 (25%)
		IG_like	416..504	CDD:214653	24/89 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900