DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and tutl

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	106/458 - (23%)
Similarity:	167/458 - (36%)	Gaps:	89/458 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LGQLDSTSSGGSG----------TGGAPPDRPPTPPLSLQPSTPSITHFVNESFIIFCQ--TVQK 74
            :|:....:..|.|          .|||....|||....|:          .|..|..|:  .:..
  Fly   319 IGEYTCIARNGEGQVSHTARVIIAGGAVIMVPPTNQTKLE----------GEKVIFSCEAKAMPG 373

  Fly    75 DIDTKWRDPRGQTRE--NTKGRVHIEKKTTGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVE 137
            ::..:|.......||  ..:.||.|.|..    :|:...|..:|.|.:.|||.   ||   :...
  Fly   374 NVTVRWYREGSPVREVAALETRVTIRKDG----SLIINPIKPDDSGQYLCEVT---NG---IGDP 428

  Fly   138 REFLASFELLVNQKISFGKTEQVQSVREGRDAMVNCFVEGMPAPE-VSWLYNGEYINTVNSTKHN 201
            :...|...:....|::|..|.|....|..  .:|.|:::..|..: |:|            ||..
  Fly   429 QSASAYLSVEYPAKVTFTPTVQYLPFRLA--GVVQCYIKSSPQLQYVTW------------TKDK 479

  Fly   202 RL------------SNG-LYIRNVSQADAGEYTCRAMRITPTFSDSDQITILLRIQHKPHWFFNE 253
            ||            :|| |....|::...|:|.|.......|...|..:.:|:|   ||..|..|
  Fly   480 RLLEPYQMKDIVVMANGSLLFTRVNEEHQGQYACTPYNAQGTAGASGVMDVLVR---KPPAFTVE 541

  Fly   254 TLPVQYAYVGGAVNLSCDAM---GEPPPSFTWLHNNKGIVGFNHRIFVADYGATLQLQMKNASQF 315
            ...:....||.:|.:.|||:   |...|:..|.......:..:.|..:...|..:.::......|
  Fly   542 PETLYQRKVGDSVEMHCDALEAEGTERPTIKWQRQEGEQLTESQRNRIKISGGNITIENLRREDF 606

  Fly   316 GDYKCKVANPLGMLERVIKL-RPGPKPLGPRRFQLKKLYTNGFELDIQ-TPRMSNVSDEMQIY-- 376
            |.|:|.|:|.:..|..|.:| ..|.:|..|.....|...::   :.:| .|..|..|:..|.|
  Fly   607 GYYQCVVSNEVATLMAVTQLVIEGTQPHAPYNITGKATESS---ITLQWLPGYSGGSEYKQDYTI 668

  Fly   377 GYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGKHFIIPHLETNTTYLMRAASRNLAGLSDWSPVK 441
            .:|.|.::|         |   :....:..|.....|..|.:.|||..:...||:.|  |....|
  Fly   669 WFREAGVND---------W---QTISVTPSGSTQVTINGLASGTTYEFQVVGRNVLG--DGMMSK 719

  Fly   442 VFT 444
            |.|
  Fly   720 VMT 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	16/72 (22%)
		IG_like	256..336	CDD:214653	20/83 (24%)
		IGc2	263..327	CDD:197706	16/66 (24%)
		FN3	341..445	CDD:238020	26/107 (24%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989
		IG_like	137..229	CDD:214653
		I-set	253..341	CDD:254352	3/21 (14%)
		IGc2	268..331	CDD:197706	2/11 (18%)
		I-set	346..437	CDD:254352	24/110 (22%)
		Ig	349..437	CDD:299845	24/107 (22%)
		Ig	459..530	CDD:299845	18/82 (22%)
		IG_like	549..628	CDD:214653	20/78 (26%)
		IGc2	551..617	CDD:197706	16/65 (25%)
		FN3	633..725	CDD:238020	26/107 (24%)
		FN3	786..874	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810