DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and negr1

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_009300786.1	Gene:	negr1 / 445374	ZFINID:	ZDB-GENE-040822-27	Length:	360	Species:	Danio rerio

Alignment Length:	388	Identity:	86/388 - (22%)
Similarity:	135/388 - (34%)	Gaps:	117/388 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTLIALCSLLLLLLSQNAAILGQ----------------------LDSTSSGGSGTGGAPPDRP 43
            ||.:||:         |:|.:.||                      :|.|:|..|
Zfish     1 MDIMIAV---------QDACVSGQWLTAIILSLCCFLPSCLPAGQTVDYTTSSES---------- 46

  Fly    44 PTPPLSLQPSTPSITHF----------VNESFIIFCQTVQKDIDTKWR-DPRGQTRENTKGRVHI 97
               .:|.|..|..:..:          :|.|.||:..      :.||. |||.....|. |..|
Zfish    47 ---VVSRQGDTALLRCYLLDGISKGAWLNRSSIIYAG------NDKWSGDPRVSIVSNV-GDKH- 100

  Fly    98 EKKTTGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQS 162
                  ..:|..:.:.:.|.|.:||.:...||.:..:         .:|:|.............:
Zfish   101 ------EYSLQIQKVDVTDEGVYTCSIQSERNLHPKL---------IQLIVKVPPKIYDISSDIT 150

  Fly   163 VREGRDAMVNCFVEGMPAPEVSWLY---------NGEYINTVNSTKHNRLSNGLYIRNVSQADAG 218
            |.||.:..:.|...|.|.|::||.:         :|||:|               |..:|:..||
Zfish   151 VNEGSNVSLICAASGKPEPKISWRHISPSARKYESGEYLN---------------ITGISRDQAG 200

  Fly   219 EYTCRAMRITPTFSDSDQITILLRIQHKP--HWFFNETL-PVQYAYVGGAVNLSCDAMGEPPPSF 280
            :|.|.|..   ..:..|..|:.:.:...|  |...:..: |.|.|.      |.|:|...|.|.|
Zfish   201 DYECGAEN---DIASPDTKTVRVTVNFPPAIHEMKSHGVRPGQVAL------LRCEAAAVPSPVF 256

  Fly   281 TWLHNNKGIVGFNHRIFVADYGATLQLQMKNASQ--FGDYKCKVANPLGMLERVIKLRPGPKP 341
            .|....|.| .....|.:.:..:...|.:||.:|  :|:|.|...|.||.....:.|.|..:|
Zfish   257 EWYKGEKRI-NMGQGIVINNLSSRSVLTVKNMTQDRYGNYTCVAVNRLGTANASVPLNPIIEP 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	18/67 (27%)
		IG_like	256..336	CDD:214653	23/81 (28%)
		IGc2	263..327	CDD:197706	18/65 (28%)
		FN3	341..445	CDD:238020	1/1 (100%)
negr1	XP_009300786.1	Ig	42..121	CDD:299845	22/105 (21%)
		IG_like	44..136	CDD:214653	24/127 (19%)
		I-set	140..222	CDD:254352	22/99 (22%)
		IGc2	153..208	CDD:197706	19/69 (28%)
		IG_like	236..312	CDD:214653	23/82 (28%)
		IGc2	238..304	CDD:197706	21/72 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830