DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and Dscam1

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	100/434 - (23%)
Similarity:	152/434 - (35%)	Gaps:	85/434 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PSITHFVNESFI-------IFCQTVQKD--IDTKWRDPRG-----------QTRENTKGRVHIEK 99
            |.|..|..|..|       :|||..:.|  |...|...|.           |.|.|     .|.:
  Fly   622 PQIVPFAYEDLINMGDSIDLFCQIQKGDRPIKVHWSFERSAGDYGFDQVQPQMRTN-----RISE 681

  Fly   100 KTTGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVR 164
            ||:   .:.....:....|..|| :..|:.|....:|        :|.||....:......::..
  Fly   682 KTS---MISIPSASPAHTGRDTC-IASNKAGTTTYSV--------DLTVNVPPRWILEPTDKAFA 734

  Fly   165 EGRDAMVNCFVEGMPAPEVSWL-----YNGEYINTVNSTKHNRLSNG-LYIRNVSQADAGEYTCR 223
            :|.||.|.|..:|.|.|:|:|.     ..||| ..:..:.:.|:..| |::.|:.:.:.|.|.|.
  Fly   735 QGSDAKVECKADGFPKPQVTWKKAVGDTPGEY-KDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCE 798

  Fly   224 AMRITPTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKG 288
            |:.   .........|::.:|..|.  |.|.|..|.|..|....|.|:|.||.|....|..||..
  Fly   799 AIN---GIGSGLSAVIMISVQAPPE--FTEKLRNQTARRGEPAVLQCEAKGEKPIGILWNMNNMR 858

  Fly   289 IVGFN-------HRIFVADYGATLQLQMKNASQFGDYKCKVANPLGMLERVIKLRPGPKPLGPRR 346
            :...|       ..|......::|.::....|....:.|...|..|..:..|.:.....|..|
  Fly   859 LDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMP-- 921

  Fly   347 FQLKKLYTNGFELDIQTPRMSNVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGKHF 411
            :.||.|..:|..:.:...:..:.:..:..|        ..|||.|..:||...:          .
  Fly   922 YALKVLDKSGRSVQLSWAQPYDGNSPLDRY--------IIEFKRSRASWSEIDR----------V 968

  Fly   412 IIP---------HLETNTTYLMRAASRNLAGLSDWSPVKVFTTA 446
            |:|         .|...|||.:|..:.|..|.|..|......||
  Fly   969 IVPGHTTEAQVQKLSPATTYNIRIVAENAIGTSQSSEAVTIITA 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	20/64 (31%)
		IG_like	256..336	CDD:214653	20/86 (23%)
		IGc2	263..327	CDD:197706	16/70 (23%)
		FN3	341..445	CDD:238020	24/112 (21%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	18/81 (22%)
		IGc2	735..804	CDD:197706	21/72 (29%)
		I-set	819..914	CDD:254352	24/96 (25%)
		Ig	833..921	CDD:299845	19/87 (22%)
		FN3	918..1011	CDD:238020	24/112 (21%)
		FN3	1018..1116	CDD:238020
		FN3	1124..1217	CDD:238020
		FN3	1222..1312	CDD:238020
		Ig	1339..1406	CDD:299845
		FN3	1409..1499	CDD:238020
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900