DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and itgb4

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	451	Identity:	84/451 - (18%)
Similarity:	141/451 - (31%)	Gaps:	165/451 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 RNGNRNVNVEREFL---------ASFELLVNQKISF-----------GKTEQVQSVR-------E 165
            ::|..|:.::|:.:         ::.:|....|..:           |:||::..|:       :
Zfish  1005 QDGVANIPIKRQIIEDGRAQVTYSTADLTAKDKKDYISVDGDLSYGAGETEKIVPVKLLELGEQD 1069

  Fly   166 G--RDAMVNCFVEGMPAPEVSWLYNGEYINTVNSTKHNRLSNGLYIRNVSQADAGEYTCRAM-RI 227
            |  .|..|..||..:..|..| ...|.|..||                ::.||..|.:..|. :.
Zfish  1070 GLLEDKQVKQFVMDLTNPRQS-AKLGRYPRTV----------------ITIADKPESSVMAFKKS 1117

  Fly   228 TPTFSDSDQI-TILLR---IQHKP---HWFFNE------TLPVQYAYVGGAVNLSCDAMGEPPPS 279
            |.|||.:|.: ||.:.   .:..|   ||..|:      :.|:::|......|:..:....|.|.
Zfish  1118 TQTFSTTDSLYTIPVERTGNRETPATVHWRTNKASRFDISSPLKFAPGEAEKNILINPRTHPSPI 1182

  Fly   280 FTWLHN-------NKGIVGFNH--RIFVAD---YGATLQLQ-MKNASQFGDYKCKVANPLGMLER 331
            .....|       |..|:|...  .:.|.|   .|.....| |:..:|      ...:|.|.|..
Zfish  1183 IPEKFNLELLDPSNNAIIGKRKTTEVIVTDGRGDGKNQDFQKMEYVTQ------TATSPGGRLYS 1241

  Fly   332 VIKLRPGPKPLGPRRFQLK---KLYTNGFE---------------LDIQTPRM------------ 366
            ...::  ....||:..:|.   ....||::               :|::||:.
Zfish  1242 PANIK--AVATGPKNIRLNWKPSQNANGYKVKYWIYGDPEDKAKFMDVKTPQAELTNLDPYCDYE 1304

  Fly   367 -----------SNVSDEMQ-------------------------------------IYGYRVAYM 383
                       .|.||.:|                                     |.||.|.||
Zfish  1305 MRVCGYNALGDGNYSDIIQCQTLEDIPGEPGRLAFNVISPTVTQVSWAEPAEANGIITGYEVIYM 1369

  Fly   384 SDTEFKFSAGNWSYAKQRDFSFHGGKHFIIPHLETNTTYLMRAASRNLAGLSDWSPVKVFT 444
            ...|.|...|.   .|:........:..:|.:|:.:.||..:..:.|..|   |.|.:..|
Zfish  1370 PINEDKKPTGP---PKKVMIDNPKKRMLLIENLQPSQTYCYKVRASNKVG---WGPYREAT 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	14/60 (23%)
		IG_like	256..336	CDD:214653	18/92 (20%)
		IGc2	263..327	CDD:197706	14/76 (18%)
		FN3	341..445	CDD:238020	31/182 (17%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344	9/58 (16%)
		FN3	1242..1326	CDD:238020	12/85 (14%)
		FN3	1331..1420	CDD:238020	17/94 (18%)
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900