DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and Prtg

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	377	Identity:	84/377 - (22%)
Similarity:	136/377 - (36%)	Gaps:	73/377 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 EDRGNWTCEVNGNRNGNRNVNVEREFLASFELL-VNQKISFGKTEQVQSVRE-----GRDAMVNC 173
            ||.|.:.|....:.:..:::.      ||..:: .|:..||.....:.|.:.     .:..::.|
  Rat   193 EDAGKYRCVAATHAHKRKSME------ASLTIVPANETRSFYMPTIIASPQNVTASLHQTVVLEC 251

  Fly   174 FVEGMPAPEVSW-LYNGEYINTVNSTKHNRLSNG-LYIRNVSQADAGEYTCRAMRITPTFSDSDQ 236
            ...|.|.|.:|| ..:.:.|:..|:   ..|.|| |.|.:|....||.|.|||  .||...:...
  Rat   252 MATGYPKPIISWSRLDHKSIDVFNT---RVLGNGNLIISDVKLQHAGVYVCRA--TTPGTRNFTV 311

  Fly   237 ITILLRIQHKP---HWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVGFNHRIFV 298
            ....|.:...|   .|..:.|.|     ..|.....|.|.|.|.|..:||.|.:.|.. |.||.:
  Rat   312 AMATLTVLAPPSFVEWPESLTRP-----RAGTARFVCQAEGIPSPKMSWLKNGRRIHS-NGRIKM 370

  Fly   299 ADYGATLQLQMKNASQFGDYKCKVANPLGML---ERVIKLRPGPKPLGPRRFQLKKLYTNGFELD 360
              |.:.|.:..........|:|...|..|.:   .|:..:....:|..|.....:.:.::...|.
  Rat   371 --YNSKLVINQIIPEDDAIYQCMAENSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLA 433

  Fly   361 IQTPRMSNVSDEMQIYGYRVAYM-----SDTEFKFSAGNWSYAKQRDFSFHGGKHFIIPHLETNT 420
            .:.|..:  ||  ::..|.|.||     ::.|::...||            ...|:||..||.::
  Rat   434 WERPLYN--SD--KVIAYSVHYMKAEGLNNEEYQVVLGN------------DTTHYIIDDLEPDS 482

  Fly   421 TYLMRAASRNLAGLSDWS--------------PVKVFTTAAG-----CSWSP 453
            .|.....:....|.|..|              |.::..|:..     .||.|
  Rat   483 NYTFYIVAYMPMGASQMSDHVTQNTLEDVPLRPPEISLTSRSPTDILISWLP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	18/65 (28%)
		IG_like	256..336	CDD:214653	21/82 (26%)
		IGc2	263..327	CDD:197706	18/63 (29%)
		FN3	341..445	CDD:238020	23/122 (19%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	48..58	CDD:409353
		Ig strand C	62..68	CDD:409353
		Ig strand C'	70..73	CDD:409353
		Ig strand D	78..83	CDD:409353
		Ig strand E	85..91	CDD:409353
		Ig strand F	103..110	CDD:409353
		Ig strand G	114..124	CDD:409353
		Ig	131..218	CDD:416386	6/30 (20%)
		Ig strand B	146..150	CDD:409353
		Ig strand C	159..163	CDD:409353
		Ig strand E	183..187	CDD:409353
		Ig strand F	197..202	CDD:409353	1/4 (25%)
		Ig strand G	211..214	CDD:409353	0/8 (0%)
		Ig_3	230..302	CDD:404760	21/76 (28%)
		Ig strand B	247..251	CDD:409353	0/3 (0%)
		Ig strand C	260..264	CDD:409353	1/3 (33%)
		Ig strand E	282..286	CDD:409353	2/3 (67%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	24/92 (26%)
		Ig strand C	352..357	CDD:409353	1/4 (25%)
		Ig strand C'	359..362	CDD:409353	0/2 (0%)
		Ig strand D	367..371	CDD:409353	2/5 (40%)
		Ig strand E	373..378	CDD:409353	1/4 (25%)
		Ig strand F	387..394	CDD:409353	2/6 (33%)
		Ig strand G	398..407	CDD:409353	1/8 (13%)
		FN3	414..507	CDD:238020	22/108 (20%)
		FN3	512..605	CDD:238020	5/23 (22%)
		fn3	619..694	CDD:394996
		FN3	721..809	CDD:238020
		FN3	816..906	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100