DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	111/590 - (18%)
Similarity:	185/590 - (31%)	Gaps:	240/590 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 VNESFIIFCQTVQKDIDTKWRDPRGQTRENTKGRVHIEKKTTGLLA-LVFEHIALEDRGNWTCEV 124
            |.||....|..:.:.....|.:|:|:...:|: ||.::|:  |:.: |...:..:||.|.:.|:.
  Rat    34 VGESKFFTCTAIGEPESIDWYNPQGEKIISTQ-RVMLQKE--GVRSRLTIYNANIEDAGIYRCQA 95

  Fly   125 NGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVREGRDAMVNCFVEGMPAPEVSWLYNG 189
            ...:...:...|..|        :.||::|.:....|..::|.||.|.|.|...|||.|||||:.
  Rat    96 TDAKGQTQEATVVLE--------IYQKLTFREVLSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHN 152

  Fly   190 EYINTVNSTKH-------------NRLSNGLY--------------------------------- 208
            |.:.|:...:.             |:...|:|
  Rat   153 EEVTTIPDNRFAVLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIVMPQKS 217

  Fly   209 --------------------------------------------------IRNVSQADAGEYTCR 223
                                                              :||:...|.|.|.|:
  Rat   218 FNATAERGEEMTLTCKASGSPDPAISWFRNGKLIEENEKYILKGSNTELTVRNIINKDGGSYVCK 282

  Fly   224 AMR--------------ITP---------------------------------------TFSDSD 235
            |..              :.|                                       |||:.|
  Rat   283 ATNKAGEDQKQAFLQVFVQPHILQLKNETTSENGHVTLICEAEGEPVPEITWKRAIDGVTFSEGD 347

  Fly   236 ------------------------------------------QITILLRIQHKPHWFFNETLPVQ 258
                                                      |.::.|.|::.|.:..|:|:  .
  Rat   348 KSPDGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGHQRSMHLDIEYAPKFVSNQTM--Y 410

  Fly   259 YAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVGFN------HRIFVADYGATLQLQMKNAS--QF 315
            |::.|..:|:|||....||.|..|......:...|      |.:     |..:.|::...|  .|
  Rat   411 YSWEGNPINISCDVKANPPASIHWRREKLVLPAKNTTHLKTHSV-----GRKMILEIAPTSDNDF 470

  Fly   316 GDYKCKVANPLGMLERVIKLRPGPKPLGPRRFQLKKLYTNGFELDIQTPRMSNVSDE----MQIY 376
            |.|.|...|.:|...:...|.....|..||..::       .||...|.::|....|    :.|:
  Rat   471 GRYNCTATNRIGTRFQEYILELADVPSSPRGVKI-------IELSQTTAKISFNKPESHGGVPIH 528

  Fly   377 GYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGK-HFIIPHLETNTTYLMRAASRNLAGLSDWSPV 440
            .|:|    |.: :.::..|...:.     ||.: ..::..||.||||.:|.|:.|..|..|:|.:
  Rat   529 HYQV----DVK-EVTSETWKIVRS-----HGVQTTVVLSSLEPNTTYEVRVAAVNGKGQGDYSKI 583

  Fly   441 KVFTT 445
            ::|.|
  Rat   584 EIFQT 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	25/154 (16%)
		IG_like	256..336	CDD:214653	21/87 (24%)
		IGc2	263..327	CDD:197706	19/71 (27%)
		FN3	341..445	CDD:238020	28/108 (26%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452	19/89 (21%)
		Ig strand B	38..42	CDD:409452	0/3 (0%)
		Ig strand C	50..54	CDD:409452	0/3 (0%)
		Ig strand E	76..80	CDD:409452	1/3 (33%)
		Ig strand F	90..95	CDD:409452	1/4 (25%)
		Ig strand G	104..107	CDD:409452	0/2 (0%)
		IGc2	128..189	CDD:197706	19/60 (32%)
		Ig strand B	130..139	CDD:409353	4/8 (50%)
		Ig strand C	145..153	CDD:409353	5/7 (71%)
		Ig strand C'	156..159	CDD:409353	1/2 (50%)
		Ig strand D	162..167	CDD:409353	0/4 (0%)
		Ig strand E	168..175	CDD:409353	0/6 (0%)
		IgI_1_MuSK	209..298	CDD:409562	7/88 (8%)
		Ig strand B	228..232	CDD:409562	0/3 (0%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	0/3 (0%)
		Ig strand F	278..283	CDD:409562	2/4 (50%)
		Ig strand G	291..294	CDD:409562	0/2 (0%)
		Ig	300..397	CDD:416386	7/96 (7%)
		Ig strand A	300..305	CDD:409353	1/4 (25%)
		Ig strand A'	309..313	CDD:409353	0/3 (0%)
		Ig strand B	317..325	CDD:409353	0/7 (0%)
		Ig strand C	331..337	CDD:409353	0/5 (0%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	0/5 (0%)
		Ig strand E	362..368	CDD:409353	0/5 (0%)
		Ig strand F	376..384	CDD:409353	0/7 (0%)
		Ig strand G	387..397	CDD:409353	2/9 (22%)
		Ig_3	401..479	CDD:404760	22/84 (26%)
		Ig strand B	418..422	CDD:409353	1/3 (33%)
		Ig strand C	431..435	CDD:409353	1/3 (33%)
		Ig strand E	458..462	CDD:409353	1/3 (33%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	28/108 (26%)
		fn3	594..678	CDD:394996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I10927
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910