DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and NEGR1

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	296	Identity:	68/296 - (22%)
Similarity:	107/296 - (36%)	Gaps:	70/296 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FVNESFIIFCQTVQKDIDTKWR-DPRGQTRENTKGRVHIEKKTTGLLALVFEHIALEDRGNWTCE 123
            ::|.|.|||..      ..||. ||          ||.|........:|..:::.:.|.|.:||.
Human    71 WLNRSSIIFAG------GDKWSVDP----------RVSISTLNKRDYSLQIQNVDVTDDGPYTCS 119

  Fly   124 VNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVREGRDAMVNCFVEGMPAPEVSWLY- 187
            |. .::..|.:.|        .|.|.............:|.||.:..:.|...|.|.|.:||.:
Human   120 VQ-TQHTPRTMQV--------HLTVQVPPKIYDISNDMTVNEGTNVTLTCLATGKPEPSISWRHI 175

  Fly   188 --------NGEYINTVNSTKHNRLSNGLYIRNVSQADAGEYTCRAMRITPTFSDSDQITILLRIQ 244
                    ||:|::               |..:::..||||.|.|.. ..:|.|..::.:::..
Human   176 SPSAKPFENGQYLD---------------IYGITRDQAGEYECSAEN-DVSFPDVRKVKVVVNF- 223

  Fly   245 HKPHWFFNETLPVQYAYVGGAVN------LSCDAMGEPPPSFTWLHNNKGIVGFNHRIFVADYGA 303
                      .|.......|.|.      :.|:..|.|||:|.|....|.:......|.:.::..
Human   224 ----------APTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFEWYKGEKKLFNGQQGIIIQNFST 278

  Fly   304 TLQLQMKNASQ--FGDYKCKVANPLGMLERVIKLRP 337
            ...|.:.|.:|  ||:|.|..||.||.....:.|.|
Human   279 RSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNP 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	17/67 (25%)
		IG_like	256..336	CDD:214653	23/87 (26%)
		IGc2	263..327	CDD:197706	20/71 (28%)
		FN3	341..445	CDD:238020
NEGR1	NP_776169.2	IG	47..135	CDD:214652	21/88 (24%)
		IGc2	152..210	CDD:197706	18/73 (25%)
		Ig_3	225..301	CDD:372822	19/75 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830