Protein Alignment CG33543 and DCC

DIOPT Version :10

• Sequence 1: NP_001014458.3
• Gene: CG33543 / 3346207
• FlyBaseID: FBgn0053543
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_005206.2
• Gene: DCC / 1630
• HGNCID: 2701
• Length: 1447
• Species: Homo sapiens
• Alignment Length: 466
• Identity: 105/466 - (22%)
• Similarity: 176/466 - (37%)
• Gaps: 104/466 - (22%)

  Fly    47 PLSLQPSTPSITHFVNESFIIFCQTVQKDIDTKWRDPRGQTRENTKGRVHIEKKTTGLL------ 105
            ||.....|.|:|.|:.::.::.|:.:.:.:.|                :|.:|....|.
Human   139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT----------------IHWQKNQQDLTPIPGDS 187

  Fly   106 --------ALVFEHIALEDRGNWTCEVN---GNRNGNRNVNVEREFLASFELLVNQKISFGKTEQ 159
                    ||....:...|.|.:.|...   .:|.||     |.|.....:..:::::.|.:...
Human   188 RVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGN-----EAEVRILSDPGLHRQLYFLQRPS 247

  Fly   160 VQSVREGRDAMVNCFVEGMPAPEVSWLYNGEYINTVNSTKHNRL-SNGLYIRNVSQADAGEYTCR 223
            .....||:||::.|.|.|.|.|..:|| .||.:..:.|.|::.| .:.|.|.||:..|:|.|||.
Human   248 NVVAIEGKDAVLECCVSGYPPPSFTWL-RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCV 311

  Fly   224 AMRITPTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKG 288
            ........|.|.::|:|:     |.||.|....: |||....:...|...|:|.|:..|:.|...
Human   312 VTYKNENISASAELTVLV-----PPWFLNHPSNL-YAYESMDIEFECTVSGKPVPTVNWMKNGDV 370

  Fly   289 IVGFNHRIFVADY-----GATLQLQMKNASQFGDYKCKVANPLGMLERVIKLRPGPKPLGPR--- 345
            ::       .:||     |:.|::.....|..|.|:|...|..|..:...:|.. |||..|.
Human   371 VI-------PSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-PKPAIPSSSV 427

  Fly   346 -----RFQLKKLYTNGF-ELDIQTPRMSNVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFS 404
                 |..:..|.::.| .|..:.|  :.....:|.:         |.| ||....:..:..:.:
Human   428 LPSAPRDVVPVLVSSRFVRLSWRPP--AEAKGNIQTF---------TVF-FSREGDNRERALNTT 480

  Fly   405 FHGGKHFIIPHLETNTTYLMRAASRNLAGLSDWS-PVKVFT--------------------TAAG 448
            ..|.....:.:|:....|..|..:.|..|..:.| |:||.|                    |:..
Human   481 QPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSIL 545

  Fly   449 CSWSPWLYPSY 459
            .:|.|   |:|
Human   546 ITWEP---PAY 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	Ig	<71..>123	CDD:472250	8/65 (12%)
		Ig strand E	105..109	CDD:409353	2/17 (12%)
		Ig strand F	119..123	CDD:409353	0/3 (0%)
		Ig	153..239	CDD:472250	28/86 (33%)
		Ig strand B	169..173	CDD:409353	1/3 (33%)
		Ig strand C	182..186	CDD:409353	0/3 (0%)
		Ig strand E	205..209	CDD:409353	1/3 (33%)
		Ig strand F	219..224	CDD:409353	3/4 (75%)
		Ig strand G	232..235	CDD:409353	1/2 (50%)
		IG_like	256..336	CDD:214653	19/84 (23%)
		Ig strand B	266..270	CDD:409353	0/3 (0%)
		Ig strand C	279..283	CDD:409353	0/3 (0%)
		Ig strand E	302..309	CDD:409353	2/6 (33%)
		Ig strand F	317..322	CDD:409353	2/4 (50%)
		FN3	341..445	CDD:238020	23/133 (17%)
DCC	NP_005206.2	IgI_1_Neogenin_like	39..136	CDD:409387
		Ig strand A	39..42	CDD:409387
		Ig strand A'	45..51	CDD:409387
		Ig strand B	55..65	CDD:409387
		Ig strand C	70..76	CDD:409387
		Ig strand C'	78..81	CDD:409387
		Ig strand D	88..93	CDD:409387
		Ig strand E	95..101	CDD:409387
		Ig strand F	113..120	CDD:409387
		Ig strand G	125..136	CDD:409387
		Ig_3	139..216	CDD:464046	16/92 (17%)
		I-set	241..327	CDD:400151	28/86 (33%)
		Ig strand B	257..261	CDD:409562	1/3 (33%)
		Ig strand C	270..274	CDD:409562	0/3 (0%)
		Ig strand E	293..297	CDD:409562	1/3 (33%)
		Ig strand F	307..312	CDD:409562	3/4 (75%)
		Ig strand G	322..325	CDD:409562	1/2 (50%)
		Ig	334..417	CDD:472250	21/90 (23%)
		Ig strand B	348..352	CDD:409388	0/3 (0%)
		Ig strand C	361..365	CDD:409388	0/3 (0%)
		Ig strand E	383..387	CDD:409388	1/3 (33%)
		Ig strand F	397..402	CDD:409388	2/4 (50%)
		Ig strand G	410..413	CDD:409388	0/2 (0%)
		FN3	429..521	CDD:238020	20/103 (19%)
		FN3	<478..901	CDD:442628	16/79 (20%)
		FN3	946..1041	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1152
		Neogenin_C	1148..1445	CDD:461954
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1165..1222
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1330
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1419
		Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953	1432..1439