DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33543 and ncam1

DIOPT Version :9

Sequence 1:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	XP_017951446.2	Gene:	ncam1 / 100038291	XenbaseID:	XB-GENE-923171	Length:	1119	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	87/421 - (20%)
Similarity:	172/421 - (40%)	Gaps:	57/421 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPTPPLSLQPSTPSITHFVNESFIIFCQTVQKDIDTKWRDP------RGQTRENTKGRVHIEKKT 101
            |||  :..:....:.|..::||.::.|     |.| .:.||      :|:..|:.:.::...:..
Frog   231 PPT--VQARQIRVNATANMDESVVLSC-----DAD-GFPDPEISWLKKGEPIEDGEEKISFNEDK 287

  Fly   102 TGLLALVFEHIALEDRGNWTCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVREG 166
            :   .:....:..:|...::|..| |:.|      |.|.:...::....||::.:.:....:.|
Frog   288 S---EMTIYRVGKDDEAEYSCIAN-NKAG------EAEAIILLKVYAKPKITYVENKTAVELDE- 341

  Fly   167 RDAMVNCFVEGMPAPEVSWLYNGEYINTVNST--------KHNRLSNGLYIRNVSQADAGEYTCR 223
              ..:.|...|.|.|.:||......|::...|        :|.|:| .|.::::...|||||.|
Frog   342 --ITLTCEASGDPIPSISWRTATRNISSEEKTLDGHIVVKEHIRMS-ALTLKDIQYTDAGEYIC- 402

  Fly   224 AMRITPTFSDSDQITILLRIQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKG 288
               |.......|...:...:|:.|.   .:...|.|.:.|..||::|:.:..|....:|..:.:.
Frog   403 ---IASNAIGEDMRAMYFEVQYAPK---IKGPVVVYTWEGNPVNITCEVLAYPSAVVSWFRDGQL 461

  Fly   289 IVGFNH---RIFVADYGATLQLQMKNASQFGDYKCKVANPLGMLERVIKLRPGPKPLGPRRFQLK 350
            :...|.   :|:.....::|::...:.:.||:|.|...|.:|.......|.....|..|...:::
Frog   462 LPSSNFSNIKIYSGPSSSSLEVNPDSENDFGNYNCTAVNSIGHESSEFILVQADTPSSPAILRVE 526

  Fly   351 KLYTNGFELDIQTPRMSNVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGKHFI-IP 414
            . |::...:....|   :.:..:.|..|:      .|:|.......:||..|......:..| :.
Frog   527 P-YSSTVMVIFDEP---DATGGVPILKYK------AEWKVIGQEKWHAKYYDAKEVSAESIITVT 581

  Fly   415 HLETNTTYLMRAASRNLAGLSDWSPVKVFTT 445
            .|:..|:||::.::.|..||.|.:|.:.|||
Frog   582 GLKPETSYLVKLSAVNGKGLGDSTPSQEFTT 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	19/66 (29%)
		IG_like	256..336	CDD:214653	17/82 (21%)
		IGc2	263..327	CDD:197706	14/66 (21%)
		FN3	341..445	CDD:238020	22/104 (21%)
ncam1	XP_017951446.2	Ig	43..136	CDD:416386
		Ig strand A	43..48	CDD:409353
		Ig strand A'	51..55	CDD:409353
		Ig strand B	57..67	CDD:409353
		Ig strand C	71..77	CDD:409353
		Ig strand C'	80..82	CDD:409353
		Ig strand D	89..95	CDD:409353
		Ig strand E	97..105	CDD:409353
		Ig strand F	112..120	CDD:409353
		Ig strand G	124..135	CDD:409353
		IG	144..210	CDD:214652
		IgI_3_NCAM-1	231..325	CDD:143207	20/111 (18%)
		Ig strand B	251..255	CDD:143207	0/3 (0%)
		Ig strand C	264..268	CDD:143207	0/3 (0%)
		Ig strand E	288..292	CDD:143207	0/6 (0%)
		Ig strand F	302..307	CDD:143207	1/4 (25%)
		Ig strand G	315..318	CDD:143207	1/2 (50%)
		Ig	324..419	CDD:416386	23/102 (23%)
		Ig strand A	324..329	CDD:409353	1/4 (25%)
		Ig strand A'	333..337	CDD:409353	0/3 (0%)
		Ig strand B	341..349	CDD:409353	2/10 (20%)
		Ig strand C	355..361	CDD:409353	2/5 (40%)
		Ig strand C'	364..367	CDD:409353	1/2 (50%)
		Ig strand D	375..381	CDD:409353	0/5 (0%)
		Ig strand E	384..390	CDD:409353	2/6 (33%)
		Ig strand F	398..406	CDD:409353	5/11 (45%)
		Ig strand G	409..419	CDD:409353	1/9 (11%)
		Ig_3	423..500	CDD:404760	16/79 (20%)
		Ig strand B	439..443	CDD:409353	2/3 (67%)
		Ig strand C	452..456	CDD:409353	0/3 (0%)
		Ig strand E	479..483	CDD:409353	1/3 (33%)
		Ig strand F	493..498	CDD:409353	2/4 (50%)
		FN3	517..612	CDD:238020	22/104 (21%)
		FN3	624..709	CDD:238020
		Herpes_BLLF1	<776..>1116	CDD:282904
		PRK07994	<918..1075	CDD:236138
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910