DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-II and SIGLEC6

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	XP_011525835.1	Gene:	SIGLEC6 / 946	HGNCID:	10875	Length:	464	Species:	Homo sapiens

Alignment Length:	345	Identity:	80/345 - (23%)
Similarity:	135/345 - (39%)	Gaps:	82/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EGKSVSLPC--PITEPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQPRHWSAPEVFGSRAKFHF 123
            ||..|.:||  |.|.|........||.:.|.:|:.:.| .|:|.:|:           :|.:||.
Human    43 EGLCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATND-PDEEVQEE-----------TRGRFHL 95

  Fly   124 DSQP----ATLEI---KRHDQGIYRCRVD---FRTSQTQSFRFNLSVIILPEQPIIMDRWGRQLN 178
            ...|    .:|.|   :|.|...|..|:.   .:...|.| :.::.|:.|..:|.|      .:.
Human    96 LWDPRRKNCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSS-KLSVRVMALTHRPNI------SIP 153

  Fly   179 GTQLGPKQEGDDIVITCRV----VGGRPQPQVRWLVNGLLVDNQNEHNSGD-VIENRLLWPSVQR 238
            ||    .:.|....:||.|    ..|.| |...|:       :....:.|. ..::.:|..:.:.
Human   154 GT----LESGHPSNLTCSVPWVCEQGTP-PIFSWM-------SAAPTSLGPRTTQSSVLTITPRP 206

  Fly   239 NDLNSVFTCQALNTQLDKPKEKSFILD----MHLKPL-------------------VVKILEPPS 280
            .|.::..|||..........|::..|:    :...||                   ..|||:..|
Human   207 QDHSTNLTCQVTFPGAGVTMERTIQLNVSWMLRRPPLSTPDAPQKVAISIFQGNSAAFKILQNTS 271

  Fly   281 SM--IADRRYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISKNSTRSELSFVPTTDDDGKSITC 343
            |:  :..:...:.|::.|: |.|.::|::|...|..|  .|| |:...||..|.:.::.  ..||
Human   272 SLPVLEGQALRLLCDADGN-PPAHLSWFQGFPALNAT--PIS-NTGVLELPQVGSAEEG--DFTC 330

  Fly   344 RAENPNVN---GLYLETMWK 360
            ||::|..:   .|.|...||
Human   331 RAQHPLGSLQISLSLFVHWK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	28/110 (25%)
		Ig	57..160	CDD:299845	28/110 (25%)
		Ig	188..251	CDD:299845	14/67 (21%)
		Ig	289..363	CDD:299845	23/75 (31%)
		IG_like	289..351	CDD:214653	19/61 (31%)
		Ig_2	376..460	CDD:290606
		IG_like	383..454	CDD:214653
		Ig	470..548	CDD:299845
		IG_like	481..557	CDD:214653
SIGLEC6	XP_011525835.1	Ig	31..141	CDD:299845	28/110 (25%)
		IG_like	36..141	CDD:214653	28/110 (25%)
		Ig_3	147..218	CDD:290638	18/88 (20%)
		I-set	265..347	CDD:254352	26/87 (30%)
		Ig	277..347	CDD:299845	21/75 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000