DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-II and Nphs1

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	1200	Identity:	240/1200 - (20%)
Similarity:	366/1200 - (30%)	Gaps:	433/1200 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LHSTSG------VGM--SGGGSSMGPGGGGSGSGGISSKDSHVKTKDIDAVEGKSVSLPCPITEP 74
            :|.||.      :||  ||...|..|.....|...:|        :::.||||.:|.|.|.:..|
  Rat    16 IHRTSSLTPLLLMGMLTSGLAESPVPTSAPQGFWALS--------ENLTAVEGTTVKLWCGVRAP 72

  Fly    75 LDNVYMVLWFRDN---------AGIPLYSF----------------DVRDKESRE---------- 104
            ..   :|.|.:|.         .|.|.||.                |:.|....|
  Rat    73 GS---VVQWAKDGLLLGPNPKMPGFPRYSLEGDRAKGEFHLLIEACDLSDDAEYECQVGRSELGP 134

  Fly   105 -------------QPR------------HW----------------SAPEVF------------- 115
                         .|:            .|                .||::.
  Rat   135 ELVSPKVILSILVSPKVLLLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDITFIQSGRTILDVSS 199

  Fly   116 ----GSRAKFHFDSQPATLEIKRHDQG-IYRCR-----VDFRTSQTQSFRFNLSVIILPEQPIIM 170
                ||..|.......|.:..:..|.| :..|.     :|  |....||..|   |:.|..|.::
  Rat   200 NVNEGSEEKLCITEAEARVIPQSSDNGQLLVCEGSNPALD--TPIKASFTMN---ILFPPGPPVI 259

  Fly   171 DRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQ--NEHNSGDVIENRLLW 233
            | |    .|...|..:.|:::.:.|...||.|...::||.||..|...  .||  ...:.:.:|.
  Rat   260 D-W----PGLNEGHVRAGENLELPCTARGGNPPATLQWLKNGKPVSTAWGTEH--AQAVAHSVLV 317

  Fly   234 PSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSR 298
            .:|:..|..:..:||:.|:.....:|:|..|.:...|..:.||...|.. .::...:.|.:..||
  Rat   318 MTVRPEDHGARLSCQSYNSVSAGTQERSITLQVTFPPSAITILGSVSQS-ENKNVTLCCLTKSSR 381

  Fly   299 PNAIITWYKGKRQLRRTKDDI-----SKNSTRSELSFVPTTDDDGKSITCRAENPNVNGLYLETM 358
            |..::.|:.|.|||..|.:.:     ..:.:.|.|:|:...:|:|..:||.|.:   :....||.
  Rat   382 PRVLLRWWLGGRQLLPTDETVMDGLHGGHISMSNLTFLVRREDNGLPLTCEAFS---DAFSKETF 443

  Fly   359 WK---LNVVYPP---------------------LVTLRL-------------------------- 373
            .|   |||.||.                     ||.|.:
  Rat   444 KKSLTLNVKYPAQKLWIEGPPEGQYIRTGTRVRLVCLAIGGNPDPSLIWFKDSRPVSEPRQPQEP 508

  Fly   374 -----------GSTLT---------PDD----------------------------------IKE 384
                       |||.:         ||:                                  ::.
  Rat   509 RRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSCKAGQLSASTQLVVQFPPTNLTILANSSALRP 573

  Fly   385 GDDVYFEC-HVQSNPQWRKLLWLHNGIHLE------HNTSARVIRSNQSLVLQKITKHYAGNYAC 442
            ||.:...| .:.|||. ..|.|...|..||      .:...:...:::|:.|:..::.:.....|
  Rat   574 GDALNLTCVSISSNPP-VNLSWDKEGERLEDVAAKPQSAPFKGSAASRSVFLRVSSRDHGQRVTC 637

  Fly   443 SAINDE-GETVSNQLPLRVKYTPMCKHADRVILIGASKDETVEVVCEIQADPPPRTFRWKFNNSG 506
            .|.::. .||||:.....|.|.|... .::|..:...:...|.:...:.|:|.|..|.|.|.  |
  Rat   638 RAHSEALRETVSSFYRFNVLYPPEFL-GEQVRAVTVVEQGQVLLPVSVSANPAPEAFNWTFR--G 699

  Fly   507 ETLD-VGSERFSVNGSRSILKYTPVTDQDYGTLSCWASNEVGTQQHPCLFQVVLAALPNAVSNCT 570
            ..|. .|..|..:. |...|:...||..|.|.......|..||.:......|..|....|:.:.|
  Rat   700 YRLSPAGGPRHRIL-SGGALQLWNVTRADDGFYQLHCQNSEGTAEALLKLDVHYAPTIRALRDPT 763

  Fly   571 VFNRTELSVDIQCIPGYDGGLPQIFVLEMFSTRTGITRFNLSNAEEALFSLENLDTLTSMMVQEN 635
            ..| ...||||.|....:..||::|..|           .|...||.|    |||.:..:.....
  Rat   764 EVN-VGGSVDIVCTVDANPILPEMFSWE-----------RLGEEEEDL----NLDDMEKVSKGST 812

  Fly   636 NSLRLRIYSYNQKG--------------RSAAYLLTDFI--------IGSTAYKTDDDVTLTL-- 676
            ..||:|....:|.|              |....|:..|.        :...|...|...:.||
  Rat   813 GRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDQPTPLTKVAAAGDSTSSATLHC 877

  Fly   677 --------------------------------SPVIVGSVLTIIIIGVAIAIRIFVVTFVHNL-- 707
                                            ..|:..|:|||..:..|....:|..|..:.|
  Rat   878 RARGVPNIDFTWTKNGVPLDLQDPRYTEHRYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGS 942

  Fly   708 -----------RRNRHHGSKAT-----AAGVTAQPSDVFKGG----------NLEKPRWQHTDIK 746
                       |.:...|.|..     :.|:..:|.  |.||          .||.|.:.|.
  Rat   943 DHTNIQLVSISRPDPPLGLKVVSISPHSVGLEWKPG--FDGGLPQRFQIRYEALETPGFLHV--- 1002

  Fly   747 TKSSEDLVEDERDPDVIPSQYVGGSSAGSSGSNASNVGSTTAGTATGSSTST-----AVVANANA 806
                          ||:|:|                   .|..|.||...||     .:.:||
  Rat  1003 --------------DVLPTQ-------------------ATTFTLTGLKPSTRYRIWLLASNA-- 1032

  Fly   807 AASAMAGPGGATSSASATDGHQFASGTAAAGGGASKWSPNGNVTTTMLTGDAVNATVTYNQINAQ 871
                 .|..|.|..     |.|.:..|  .|...:....:..:.|.:..|             ..
  Rat  1033 -----LGDSGLTDK-----GIQVSVTT--PGPDQAPEDTDHQLPTELPPG-------------PP 1072

  Fly   872 RAQLLAAVAAVGGGCSSTVISPSSSILGGL 901
            |..||..:.||||    .::..::|.:|||
  Rat  1073 RLPLLPVLFAVGG----LLLLSNASCVGGL 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	34/203 (17%)
		Ig	57..160	CDD:299845	34/201 (17%)
		Ig	188..251	CDD:299845	17/64 (27%)
		Ig	289..363	CDD:299845	22/81 (27%)
		IG_like	289..351	CDD:214653	18/66 (27%)
		Ig_2	376..460	CDD:290606	22/134 (16%)
		IG_like	383..454	CDD:214653	18/78 (23%)
		Ig	470..548	CDD:299845	19/78 (24%)
		IG_like	481..557	CDD:214653	20/76 (26%)
Nphs1	NP_072150.1	Ig	52..128	CDD:299845	19/86 (22%)
		IG_like	52..127	CDD:214653	19/85 (22%)
		C2-set_2	155..242	CDD:285423	12/88 (14%)
		Ig_3	256..335	CDD:290638	22/85 (26%)
		IG_like	268..350	CDD:214653	21/83 (25%)
		C2-set_2	358..440	CDD:285423	21/85 (25%)
		I-set	460..555	CDD:254352	8/94 (9%)
		Ig	472..555	CDD:299845	8/82 (10%)
		Ig	563..646	CDD:299845	15/83 (18%)
		IG_like	670..750	CDD:214653	20/82 (24%)
		Ig	676..750	CDD:299845	20/76 (26%)
		Ig_3	753..834	CDD:290638	25/96 (26%)
		IG_like	762..848	CDD:214653	25/101 (25%)
		Ig	848..956	CDD:299845	15/107 (14%)
		IG_like	859..949	CDD:214653	13/89 (15%)
		FN3	955..1049	CDD:238020	28/143 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810