DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment side-II and Nphs1

DIOPT Version :9

Sequence 1:NP_001014485.3 Gene:side-II / 3346206 FlyBaseID:FBgn0259213 Length:1064 Species:Drosophila melanogaster
Sequence 2:NP_062332.2 Gene:Nphs1 / 54631 MGIID:1859637 Length:1256 Species:Mus musculus


Alignment Length:884 Identity:187/884 - (21%)
Similarity:294/884 - (33%) Gaps:262/884 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 EGKSVSLPCPITEPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQPRHWSAPEVFGSRAKFHFDS 125
            |.|:|:|.|........|.:..|......:|       ..|:.....|..           |...
Mouse   367 ENKNVTLCCLTKSSRPRVLLRWWLGGRQLLP-------TDETVMDGLHGG-----------HISM 413

  Fly   126 QPATLEIKRHDQGI-YRCRVDFRTSQTQSFRFNLSV-IILPEQPIIMDRWGRQLNGTQLGPK-QE 187
            ...||.:||.|.|: ..|.........::|:.:|:: :..|.|.:    |   :.|...|.. :.
Mouse   414 SNLTLLVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYPAQKL----W---IEGPPEGQSIRT 471

  Fly   188 GDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNE------------HNSGDVIENRLLWPSVQRND 240
            |..:.:.|..:||.|:|.:.||.:...|::..:            ..||......|:. .:...|
Mouse   472 GTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVL-IIGPPD 535

  Fly   241 LNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAIITW 305
            ..:.|:|:|  .||....:    |.:...|..:.||...|::.......::|.|..|.|...::.
Mouse   536 NLAKFSCKA--GQLSASTQ----LVVQFPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSL 594

  Fly   306 YKGKRQLRRTKDDIS--------KNSTRSELSFVPTTD-DDGKSITCRAENPNVNGLYLETMWKL 361
            .|...:|    ||::        |.|..|...|:..:. |.|..:||||.:..:... :.:.::|
Mouse   595 DKEGERL----DDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAHSEALRET-VSSFYRL 654

  Fly   362 NVVYPPLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHNTSAR-VIRSNQ 425
            ||:|||..   ||..:....:.|.........|.:||......|...|..|......| .|.|..
Mouse   655 NVLYPPEF---LGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGG 716

  Fly   426 SLVLQKITKHYAGNYACSAINDEGETVSNQLPLRVKYTPMCKHADRVILIGASKDET-------V 483
            :|.|..:|:...|.|.....|.|| |....|.|.|.|.|         .|.|.||.|       |
Mouse   717 ALQLWNVTRADDGFYQLHCQNSEG-TAEALLKLDVHYAP---------TIRALKDPTEVNVGGSV 771

  Fly   484 EVVCEIQADP-PPRTFRW--------KFN-------NSGET--LDVGSERFSVNGS--------- 521
            ::||.:.|:| .|..|.|        :.|       :.|.|  |.:...:.|..|:         
Mouse   772 DIVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGV 836

  Fly   522 --------RSILKYTPVTD---------------------------------------------- 532
                    |.::::.|..|                                              
Mouse   837 APAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDP 901

  Fly   533 -------------------------QDYGTLSCWASNEVGTQQHPCLFQVVLAALPNAVSNCTVF 572
                                     |||....|.|:|.:|: .|..: |:|..:.|:......|.
Mouse   902 RYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALGS-DHTNI-QLVSISRPDPPLGLKVV 964

  Fly   573 NRTELSVDIQCIPGYDGGLPQIFVLEMFSTRT-GITRFNLSNAEEALFSLENLDTLTSMMVQENN 636
            :.:..||.::..||:||||||.|.:...:..: |....::..|:...|:|..|          ..
Mouse   965 SVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGL----------KP 1019

  Fly   637 SLRLRIY--SYNQKGRSAAYLLTDFII-------GSTAYKTDDD-----------VTLTLSPVI- 680
            |.|.||:  :.|..|.|.   |||..|       |......|.|           ..|.|.||: 
Mouse  1020 STRYRIWLLASNALGDSG---LTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLF 1081

  Fly   681 -VGSVLTIIIIGVAIAIRIFVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPRWQHTD 744
             ||.:|.:     :.|..:..:.:...|||.....|:.|.||                       
Mouse  1082 AVGGLLLL-----SNASCVGGLLWRRRLRRLAEEISEKTEAG----------------------- 1118

  Fly   745 IKTKSSEDLVEDERDPDVIPSQYVGGSSAGSSGSNASNV 783
                |.||.:.:|.:    .||:.|.....||..:.:.|
Mouse  1119 ----SEEDRIRNEYE----ESQWTGDRDTRSSTVSTAEV 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-IINP_001014485.3 IG_like 55..160 CDD:214653 20/99 (20%)
Ig 57..160 CDD:299845 20/99 (20%)
Ig 188..251 CDD:299845 16/74 (22%)
Ig 289..363 CDD:299845 19/82 (23%)
IG_like 289..351 CDD:214653 18/70 (26%)
Ig_2 376..460 CDD:290606 21/84 (25%)
IG_like 383..454 CDD:214653 19/71 (27%)
Ig 470..548 CDD:299845 28/190 (15%)
IG_like 481..557 CDD:214653 26/188 (14%)
Nphs1NP_062332.2 Ig 52..128 CDD:299845
IG_like 52..127 CDD:214653
C2-set_2 155..242 CDD:285423
Ig 254..332 CDD:299845
IG_like 268..350 CDD:214653
C2-set_2 358..440 CDD:285423 18/90 (20%)
Ig 459..544 CDD:299845 18/88 (20%)
I-set 460..555 CDD:254352 21/101 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..516 3/24 (13%)
Ig 563..646 CDD:299845 21/86 (24%)
IG_like 670..750 CDD:214653 21/80 (26%)
Ig 676..750 CDD:299845 20/74 (27%)
Ig_3 753..834 CDD:290638 20/89 (22%)
IG_like 762..848 CDD:214653 16/85 (19%)
Ig 848..956 CDD:299845 12/109 (11%)
IG_like 859..949 CDD:214653 8/91 (9%)
fn3 956..1039 CDD:278470 24/95 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1048..1071 3/22 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1143 12/61 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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