DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-II and NPHS1

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	876	Identity:	186/876 - (21%)
Similarity:	307/876 - (35%)	Gaps:	219/876 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EGKSVSLPCPITEPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQPRHWSAPEVFGSRAKFHFDS 125
            |.|:|:|.|........|.:..|......:|:       :|:.....|..           |...
Human   353 ENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPM-------EETVMDGLHGG-----------HISM 399

  Fly   126 QPATLEIKRHDQGI-YRCRVDFRTSQTQSFRFNLSV-IILPEQPIIMDRWGRQLNGTQLGPK-QE 187
            ...|...:|.|.|: ..|.........::|:.:|.: :..|.|.:    |   :.|...|.| :.
Human   400 SNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILNVKYPAQKL----W---IEGPPEGQKLRA 457

  Fly   188 GDDIVITCRVVGGRPQPQVRWLVNGLLV-------DNQNEH-----NSGDVIENRLL---WPSVQ 237
            |..:.:.|..:||.|:|.:.|..:...|       :::..|     .||......|:   .||
Human   458 GTRVRLVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPS-- 520

  Fly   238 RNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAI 302
              |..:.|||:|  .||....:    |.:...|..|.||...|::.......::|.|..|.|...
Human   521 --DNQAKFTCKA--GQLSASTQ----LAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVN 577

  Fly   303 ITWYKGKRQL-------RRT--KDDISKNSTRSELSFVPTTDDDGKSITCRAENPNVNGLYLETM 358
            ::|.|...:|       ||.  |...:..|...::|    :.|.|:.:||||.:..:... :.:.
Human   578 LSWDKEGERLEGVAAPPRRAPFKGSAAARSVLLQVS----SRDHGQRVTCRAHSAELRET-VSSF 637

  Fly   359 WKLNVVYPP---------LVTLRLGSTLTPD---------------------------------- 380
            ::|||:|.|         :..:..|..|.|.
Human   638 YRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSG 702

  Fly   381 -----DIKEGDDVYFECHVQSNPQWRKLLWLHNGIH-------LEHNTSARVIRS---------- 423
                 ::...||..::.|.| |.:......|...:|       |:..|...|..|
Human   703 ALHLWNVTRADDGLYQLHCQ-NSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDAN 766

  Fly   424 -----------------NQSL-VLQKITK--------HY-----AGNYACSAINDEGETVSNQLP 457
                             :||| .::||::        |:     ||.|.|...|.........|.
Human   767 PILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLR 831

  Fly   458 LRVKYTPMCKHADRVILIGASKDETVEVVCEIQADPPPR-TFRWKFNNSGETLDVGSERFSVNG- 520
            |.|::.|..:|...:..:.|:.|.|.......:|...|. .|.|..|  |..||:...|::.:.
Human   832 LVVRFAPQVEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN--GVPLDLQDPRYTEHTY 894

  Fly   521 -----SRSILKYTPVT-DQDYGTLSCWASNEVGTQQHPCLFQVVLAALPNAVSNCTVFNRTELSV 579
                 ..|:|....|: .|||...:|.|:|.:|:.|  ...|:|..:.|:..|...|.:.|..||
Human   895 HQGGVHSSLLTIANVSAAQDYALFTCTATNALGSDQ--TNIQLVSISRPDPPSGLKVVSLTPHSV 957

  Fly   580 DIQCIPGYDGGLPQIFVLEMFSTRT-GITRFNLSNAEEALFSLENLDTLT--------------S 629
            .::..||:||||||.|.:...:..| |....::...:...|:|..|...|              |
Human   958 GLEWKPGFDGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS 1022

  Fly   630 MMVQENNSLRLRIYSYNQ-KGRSAAYLLTDFIIGSTAYKTDDDVTLTLSPVI--VGSVLTIIIIG 691
            .:..:...|.:.....:| .|.....|.|:...|.:.        |.|.||:  :|.:|.:
Human  1023 GLADKGTQLPITTPGLHQPSGEPEDQLPTEPPSGPSG--------LPLLPVLFALGGLLLL---- 1075

  Fly   692 VAIAIRIFVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPRW------QHTDIKTKSS 750
             :.|..:..|.:...|||.....|:.|.||   ...|..: ...|:.:|      |.:.:.|..:
Human  1076 -SNASCVGGVLWQRRLRRLAEGISEKTEAG---SEEDRVR-NEYEESQWTGERDTQSSTVSTTEA 1135

  Fly   751 EDLVEDERD--PDVIPSQYVGGSSAGSSGSN 779
            |......||  |.:.|:|.....|.|.:|.:
Human  1136 EPYYRSLRDFSPQLPPTQEEVSYSRGFTGED 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	18/99 (18%)
		Ig	57..160	CDD:299845	18/99 (18%)
		Ig	188..251	CDD:299845	19/77 (25%)
		Ig	289..363	CDD:299845	19/82 (23%)
		IG_like	289..351	CDD:214653	18/70 (26%)
		Ig_2	376..460	CDD:290606	26/170 (15%)
		IG_like	383..454	CDD:214653	22/118 (19%)
		Ig	470..548	CDD:299845	21/85 (25%)
		IG_like	481..557	CDD:214653	21/83 (25%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845
		IG_like	254..336	CDD:214653
		Ig	345..424	CDD:299845	16/88 (18%)
		Ig	445..530	CDD:299845	22/91 (24%)
		I-set	446..541	CDD:254352	25/104 (24%)
		Ig	549..632	CDD:299845	21/86 (24%)
		IG_like	558..642	CDD:214653	19/88 (22%)
		I-set	646..736	CDD:254352	10/90 (11%)
		Ig	662..736	CDD:299845	9/74 (12%)
		Ig_3	739..820	CDD:290638	14/80 (18%)
		IG_like	748..821	CDD:214653	13/72 (18%)
		Ig8_hNephrin_like	834..942	CDD:143250	28/111 (25%)
		IG_like	845..935	CDD:214653	23/93 (25%)
		fn3	942..1023	CDD:278470	20/80 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		8/41 (20%)
		Binds to NPHS2	1160..1241		2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810