DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-II and hbs

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	919	Identity:	190/919 - (20%)
Similarity:	316/919 - (34%)	Gaps:	275/919 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLAMALLMPVTLARLHSTSGVGMSGGGSSMGPGGGGSGSGGISSKDSHVKTKDIDAVEGKSVSL 67
            ||....|...:.|..|::...|.:||..                           .|..|.||.|
  Fly   328 LLATTPLRAELNLTVLYAPKDVYLSGAN---------------------------QAKVGDSVQL 365

  Fly    68 PCPITEPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQPRHWSAPEVFGSRAKFHFDSQPATLEI 132
            .| :|.|.:....:.|..:  |.||.:...:...|.:  ..|    |..|......|||..|.
  Fly   366 SC-VTAPSNPQARISWSIN--GRPLDNSTYKTTSSSD--GGW----VSSSNISLTIDSQSRTF-- 419

  Fly   133 KRHDQGIYRCRVDFRTSQTQSF--RFNLSVIILPEQPIIMDRWGRQLNGTQLGPKQEGDDIV--- 192
                  |..|.. ..|..||:.  ...::|:..|..|:        |.|     ..:||.::
  Fly   420 ------IAVCHA-LNTELTQNVVGSHTVNVLYPPSPPL--------LTG-----YNDGDILISGS 464

  Fly   193 ---ITCRVVGGRPQPQVRWLVNGLLVDNQNEHNSGDVIENRL---LWPSVQRNDLNSVFTCQALN 251
               :.|...||.|.|.::|..|..:::..::     ::::::   |...|..:|.|:::.|:..|
  Fly   465 ILKLQCSSAGGNPPPTLQWYKNDKIINAPSK-----LVDSKITSELSLLVNASDNNAIYKCKVQN 524

  Fly   252 TQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGSRPNAIITWYKGKRQLR--- 313
            ..:|.|...:..|.:|..|..|||...|.:::...|.::.|:||.|.|.|.|:|:|....:.
  Fly   525 AAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPAKISWWKDGIPVEGLN 589

  Fly   314 -RTKDDISKNSTRSELSFVPTTDD-DGKSITCRAENPNVNGLYLETMWKLNVVYPPLVTLRLGST 376
             ..:..:...|..:...:|..|.| ||...||::.|..:.....||: .|:::|||.......:|
  Fly   590 LANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHETI-SLDILYPPKFETPQSTT 653

  Fly   377 LTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHN--TSARVIRSNQSLVLQKITKHYAGN 439
            ...   .||...:.|.....||......|..:|:.:..|  :..|:|.....|.:.:::::.||.
  Fly   654 FVG---VEGAPFHVELLASGNPMVITYTWTKDGLPISSNSLSGQRLISDGPRLNISRLSRNDAGV 715

  Fly   440 YACSAINDEGETVSNQLPLRVKYTPMCKHAD--RVILIGASKDETVEVVCEIQADP-PPRTFRW- 500
            |.|.|:|.:| |...::.:.|:|.|......  |..:.|    |...:.|.|||.| .....||
  Fly   716 YICEALNSQG-TALLEIQVAVEYAPTITAVSEGRSFVAG----EPAVLACHIQARPLEAAHVRWS 775

  Fly   501 ------------KFNN--------SGETLDVGSERFSVNGSRS---------ILKYTPVTD---- 532
                        .|.|        |.|..|:|:....|:..|.         :::..|..|
  Fly   776 RDGYDLATRTISSFENGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAPEIDHSPG 840

  Fly   533 ----------------------------------------------------------------- 532

  Fly   841 FTRYAARLGVRAQLICRSLASPQPSFIWRRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTS 905

  Fly   533 -QDYGTLSCWASNEVGTQQHPCLFQVVLAALPNAVSNCTVFNRTELSVDIQCIPGYDGGLPQIFV 596
             .|||...|...|.:|  |.....:....:.|:|.....|.|.::..||:...||:|||:...|.
  Fly   906 PDDYGQYECVVRNSLG--QASTTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYFR 968

  Fly   597 LEMFSTRTGITRFNLSNAEEALFSLENLDTLTSMMVQENNSLRLRIYSYNQKGRSAAYLLTDFII 661
            |.:  .:.|..::...:|:....:: :||.|     :...:....:.:.|:.|.|
  Fly   969 LRL--KQHGEDKYKYVDAKPGHQNI-SLDGL-----KPGATYYFSVMAANEAGGS---------- 1015

  Fly   662 GSTAYKTDDDVTLTLSPVIVGS------------VLTIIIIGVAIAIRIFVVT-------FVHNL 707
                 |...|:.||||.   ||            :..::|||:..|..:.:|.       ||  :
  Fly  1016 -----KFMPDIKLTLSK---GSQPHSAEYTEKDELPNVMIIGITSAAMVLLVLNAALVAWFV--I 1070

  Fly   708 RRNRHHGSKATAAG----------------VTAQPSDVFKGGNLEKPRWQHTDIKTKSSEDLVED 756
            ||.....|:|..:.                :||..:||.|              |..:|..|||
  Fly  1071 RRQNKSQSEAEPSNDDVYSKDDSQSVYKLPITALQADVQK--------------KAAASTYLVE- 1120

  Fly   757 ERDPDVIPS 765
              :.|:|.|
  Fly  1121 --NVDIIQS 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	25/106 (24%)
		Ig	57..160	CDD:299845	25/104 (24%)
		Ig	188..251	CDD:299845	14/71 (20%)
		Ig	289..363	CDD:299845	21/78 (27%)
		IG_like	289..351	CDD:214653	18/66 (27%)
		Ig_2	376..460	CDD:290606	20/85 (24%)
		IG_like	383..454	CDD:214653	19/72 (26%)
		Ig	470..548	CDD:299845	25/180 (14%)
		IG_like	481..557	CDD:214653	25/176 (14%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845
		IG_like	45..137	CDD:214653
		Ig	153..231	CDD:299845
		IG_like	258..342	CDD:214653	4/13 (31%)
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653	16/65 (25%)
		Ig	360..427	CDD:299845	21/84 (25%)
		Ig	<468..526	CDD:299845	13/62 (21%)
		I-set	547..633	CDD:254352	22/85 (26%)
		Ig	556..631	CDD:299845	19/74 (26%)
		I-set	644..735	CDD:254352	21/94 (22%)
		IGc2	668..725	CDD:197706	14/56 (25%)
		IG_like	751..829	CDD:214653	17/81 (21%)
		IGc2	753..815	CDD:197706	16/65 (25%)
		Ig	852..928	CDD:143165	7/77 (9%)
		FN3	935..1017	CDD:238020	21/104 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810