DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-II and side-VII

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	314/992 - (31%)
Similarity:	471/992 - (47%)	Gaps:	149/992 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ISSKDSHVKTKDIDAVEGKSVSLPCPIT-----EPLDNVYMVLWFRDNAGIPLYSFDVRDKESRE 104
            |.|||  |....|:::.|:::.|||.:|     ||:    :|||:||:.|.|:||.|:|...|:
  Fly    18 IGSKD--VPIHQIESIVGENIYLPCNVTTYDGDEPV----LVLWYRDDKGTPIYSIDIRAGVSK- 75

  Fly   105 QPRHWSAPEVFGSRAKFHFDSQPATLEIKR---HDQGIYRCRVDFRTSQTQSFRFNLSVIILPEQ 166
            .|:.||...|||.||.|.||.:|..|.|:.   .|.|.|||||||..:||.:.|..|:||..|:|
  Fly    76 APKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVDFLKAQTINSRIRLNVISPPKQ 140

  Fly   167 PIIMDRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEH-NSGDVIENR 230
            .||.|....: ..|.:||..|||.:.:.|:|:||.|.|.:.|..:|:.:..:..| ..|.:||..
  Fly   141 VIIRDSSNVE-RSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEIPCELSHLAGGKIIECE 204

  Fly   231 LLWPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESS 295
            :..||:.|.||||..||:||:.......|....:||:..||.:::|.....:.|.|||::.|:|:
  Fly   205 ITLPSLGREDLNSRLTCRALSHPRAPIVEAVVQIDMNFAPLNIRLLGAHQPLSAGRRYDLLCQSA 269

  Fly   296 GSRPNAIITWYKGKRQLRRTKDDISK--NSTRSELSFVPTTDDDGKSITCRAENPNVNGLYLETM 358
            ||||.|:|||::...:|.:|.:..|.  |.|.|.||...:..|.||.::|:|.|..|....||..
  Fly   270 GSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSISLSKSDAGKYLSCKAYNHAVPSEPLEDG 334

  Fly   359 WKLNVVYPPLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHNTSARVIRS 423
            |||::.|.|...:|||::|.|..::||.||||:|.|.::|...::.|.||...|.||.|..||.|
  Fly   335 WKLDIQYVPEAYVRLGTSLDPSTLREGTDVYFDCLVMAHPNVFRIEWRHNEQPLSHNISLGVIIS 399

  Fly   424 NQSLVLQKITKHYAGNYACSAINDEGETVSNQLPLRVKYTPMCKHADRVILIGASKDETVEVVCE 488
            |.|||||.:|:..||||:|...|.|||.:|....|.:.|.|.|....:.: .|.:|.|..:|:|.
  Fly   400 NHSLVLQGVTRATAGNYSCVGFNAEGEGISAPFALNILYAPTCAQNQKKV-YGIAKQEDAKVMCT 463

  Fly   489 IQADPPPRTFRWKFNNSGETLDVGSERFSVNGSRSILKYTPVTDQDYGTLSCWASNEVGTQQHPC 553
            :.|:|....|.|.||||.|::||.:.....:|:.||:.|||:|:.|||||.|.|||::|.|:.||
  Fly   464 VDANPREVEFSWTFNNSAESIDVATNHIIRSGTTSIVTYTPITELDYGTLLCLASNKIGKQRVPC 528

  Fly   554 LFQVVLAALPNAVSNCTVFNRTELSVDIQCIPGYDGGLPQIFVLEMFSTRTGITRFNLSNAEEAL 618
            :|.::.|..|..|.||||.|.:..|:.:.|..|::|||||.|.||:..:.|...:.|:::
  Fly   529 VFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEIKANITS----- 588

  Fly   619 FSLENLDTLTSMMVQENNSLRLRIYSYNQKGRSAAYLLTDFIIGSTAYKTDDDVT------LTLS 677
                .:...|...:...:..||.||::|.||||...::...::.....:...:.|      |..|
  Fly   589 ----TIPKFTVPGLSPGSIYRLNIYAFNTKGRSDPAIVNAAMLRMPEKQLTSEQTHNLRAELLFS 649

  Fly   678 PVI---VGSVLTIIIIGVAIAIRIFVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPR 739
            ||:   :|..|.:::..:||.:.:.:.....:.||.:...::..:...:..|||...|
  Fly   650 PVMSLTIGLTLAVLVAVLAIILALRIPCTASSRRRQKELSNENISRDESPGPSDKSSG------- 707

  Fly   740 WQHTDIKTKSSEDLVEDERDPDVIPSQYVGGSSAGS--SGSNASNVGSTTAGTATGSSTSTAVVA 802
                   :|..:|.  ||::|||:|........|.|  .....|.:.       |..|.:..:..
  Fly   708 -------SKEVDDC--DEKNPDVVPESIEPDEQAESIRKRQQISTID-------TNRSPNRGIFV 756

  Fly   803 NANAAASAMAGPGGATSSASATDGHQFASGTAAAGGGASKWSPNG----NVTTTMLTGDAVNATV 863
            |.....:|      |..|..|:.|..:.  |..:|..|...|..|    |||..:.:......|:
  Fly   757 NEQQHLTA------AEISLRASHGIGYC--TLRSGMHAQAQSSVGEISINVTPHVYSNSISQCTL 813

  Fly   864 -------TYNQINAQRAQLLAAVAAVGGGCSSTVISPSSSILGGLGKPLGMGMGMGLGMGVGGTV 921
                   .:|..|                |:.|...|:|: ...|..|.|.       :.|||..
  Fly   814 PRQSSQNVWNNYN----------------CNITGARPTST-FHQLTFPQGR-------VNVGGHN 854

  Fly   922 IGSP-------TSLSSTATLAAHLQPAHSSGVGTLPPGLGSGGGYILNAYASGRLHHPPGGGVPG 979
            ...|       .|.:|.:::|        |...|||.                  .||
  Fly   855 PAQPLHGHAPSPSQASNSSMA--------SSTNTLPQ------------------PHP------- 886

  Fly   980 GATHTATLNRHHHQQQQ 996
               |..|:..||..|.|
  Fly   887 ---HGRTIAMHHMNQAQ 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	47/112 (42%)
		Ig	57..160	CDD:299845	47/110 (43%)
		Ig	188..251	CDD:299845	24/63 (38%)
		Ig	289..363	CDD:299845	30/75 (40%)
		IG_like	289..351	CDD:214653	24/63 (38%)
		Ig_2	376..460	CDD:290606	39/83 (47%)
		IG_like	383..454	CDD:214653	35/70 (50%)
		Ig	470..548	CDD:299845	32/77 (42%)
		IG_like	481..557	CDD:214653	35/75 (47%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	46/106 (43%)
		V-set	32..134	CDD:284989	46/106 (43%)
		IGc2	160..>214	CDD:197706	18/53 (34%)
		Ig	262..328	CDD:299845	26/65 (40%)
		IG_like	264..323	CDD:214653	23/58 (40%)
		IGc2	360..425	CDD:197706	32/64 (50%)
		Ig_3	456..519	CDD:290638	28/62 (45%)
		FN3	538..620	CDD:238020	30/90 (33%)
		FAM176	643..741	CDD:291517	24/113 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470097
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23448at33392
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	8	7.850