DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-II and nrm

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	1298	Identity:	245/1298 - (18%)
Similarity:	391/1298 - (30%)	Gaps:	510/1298 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ISSKDSHVKTKDIDAVEGKSVSLPCPI-TEPLDNVYMVLWFRDN---AGIPLYSFDVRDKESREQ 105
            :.|..:.|.| .|...|.:||.||||: .|....::.:.||:.:   |.:.|...:|.
  Fly    38 VDSSTAQVDT-TISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDRIAAMLLGDSNVT------- 94

  Fly   106 PRHWSAPEVFGSRAKFHFDSQPATL---EIKRHDQGIYRCRVDF-----RTSQTQSFRFNLSVII 162
                |..:.|..|..  .:..|..|   ::|..|:.||.|...|     .......:|..|.|::
  Fly    95 ----SVNKEFDERVT--VEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLV 153

  Fly   163 LPEQPIIMDRWGRQL-NGTQLGPKQEGDDIVITCRVVGGRPQPQVRW---------------LVN 211
            .|.:.:|:|..|.:: ||:.:||.||...:..||.|...||||:|.|               ||:
  Fly   154 PPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPTHDLVD 218

  Fly   212 GLLVDNQNEHNSGDVIENRLLWPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKIL 276
            ||.....           .|.| ::.|.||.....|:..:..:.......|.:|:.::|..:.|.
  Fly   219 GLYTSTL-----------ELDW-TLSREDLAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDIN 271

  Fly   277 EPPSSMIADRRYEVSCESSGSRPNAIITWY-------KGKRQLRRTKDDISKNS-----TRSELS 329
            ......:...:..::|:..|:||...:|||       .|:.::...:....:.|     |:|||.
  Fly   272 GVKHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELI 336

  Fly   330 FVPTTDDDGKSITCRAEN---------PNVNGLYLETMWKLNVVYPPLVTLRLGSTLTPDDI--K 383
            |..|..::.:...|.|||         |..:.|.||      |:|||:|      .::|..|  .
  Fly   337 FNATRFENDRVFRCEAENIVLQINREKPISSALTLE------VLYPPVV------KVSPSAITAN 389

  Fly   384 EGDDVYFECHVQSNP-QWRKLLWLHNGIHLEHNTSARVIRSNQ---SLVLQKITKHYAGNYACSA 444
            ..:.|...|...:|| ...::.|..|.|.:..|.:......|.   :||::...|...|||:|..
  Fly   390 TSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQL 454

  Fly   445 INDEGETVSNQ-LPLRVKYTP-------------------------------------------- 464
            .|:.|:..|:| :.|.|:|.|
  Fly   455 SNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRWYANST 519

  Fly   465 --------------MC--------------------------------KHADRVILIG------- 476
                          :|                                :..|:.:|:.
  Fly   520 LLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAA 584

  Fly   477 -------ASKDETVEVVCEIQ--ADPPPRTFRWKFNNSGETLDVGSERFSVNGSRSILKYTPVTD 532
                   |.|.::|...|.:.  ..|....|||.....|...|:.::.::|.         ||..
  Fly   585 LSHFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLRGGRGPLQDIVTKDWTVE---------PVGL 640

  Fly   533 QDYGTLSCWASNE--------VGTQQHPCLFQV--------VLAALPNAVSNCTVFNRTELSVDI 581
            ......||:|.||        |..:.|...|.:        :|.:.|||...|.          |
  Fly   641 DSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSPNATLTCR----------I 695

  Fly   582 QCIPGYD-----GGLP------QIFVLEMF---STRTG-------ITRFNLSNAEEALFSLENLD 625
            :|:|..|     .|:|      :.|:.|.:   |..||       :..||:.|..::.|::| .|
  Fly   696 ECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIE-AD 759

  Fly   626 TLTSMMVQENN----SLRLRIY------------------------------------------- 643
            ......|...|    |:|.|.|
  Fly   760 NANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANPEPSYKWI 824

  Fly   644 -----------------------------SYNQKGRSAA-------------------------- 653
                                         :||:.|.|.|
  Fly   825 FKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKPRCEIERQEIDDQDTLI 889

  Fly   654 ---------------------------------------YLL-TDFIIGST----AYKT------ 668
                                                   |:| ||:.|..|    |..|
  Fly   890 CTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAISRTYRCVANNTVGYGPF 954

  Fly   669 ---------------DDDVTLTLSPVIVGSVLTIIIIGVAI--------------------AIRI 698
                           :.:..:.|...|:|.:||:|:|...|                    :|:.
  Fly   955 CEIEVAEQLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRRQDKYLTEVPINSIQS 1019

  Fly   699 FVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEK--PRWQ-------HTDIKTKSSEDLV 754
            .:...:...|..|:..::.....:...||.....|:..|  |||.       |....||.:..:.
  Fly  1020 ALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPRWPIRPGVMLHVSSNTKENLTVN 1084

  Fly   755 EDERDPDVI-----PSQYVGGSSAGSSGSNASNVG------STTAGTATGSSTSTAVVANANAAA 808
            .....|:|.     .||.....||..:||..::.|      |..:|....|:.|...|.|...|.
  Fly  1085 RMTVKPNVSGNRGDMSQLSAQLSAALNGSRDNSDGTILTEISAVSGENEASNLSILEVTNRKKAT 1149

  Fly   809 SAMAGPGGATSSASATDGHQFASGTAAAG-----------------------------------G 838
            ..     ....:.|..:|...:|.|.:||                                   |
  Fly  1150 VP-----STIRNVSTAEGEIISSKTHSAGHIALDHVWSLIFKKSDDRTRDSQRSHVGLLQTFWRG 1209

  Fly   839 GASKWSPNGNVTTTMLTGDAVNATVTYNQINAQRAQLLAAVAAVGGGCSSTV----ISPSSSI 897
            ..:|.|.:|..:...|.|...:.:|||.:  |:......:.||..|..|.|.    ..||.||
  Fly  1210 LGAKESTSGFESQHRLKGIRCSGSVTYKK--AKETVHSTSDAASNGESSLTKRPNNCQPSVSI 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653	27/116 (23%)
		Ig	57..160	CDD:299845	27/114 (24%)
		Ig	188..251	CDD:299845	19/77 (25%)
		Ig	289..363	CDD:299845	23/94 (24%)
		IG_like	289..351	CDD:214653	20/82 (24%)
		Ig_2	376..460	CDD:290606	23/90 (26%)
		IG_like	383..454	CDD:214653	18/74 (24%)
		Ig	470..548	CDD:299845	21/101 (21%)
		IG_like	481..557	CDD:214653	19/85 (22%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	29/121 (24%)
		Ig	176..248	CDD:299845	22/83 (27%)
		Ig	277..354	CDD:299845	17/76 (22%)
		IG_like	383..463	CDD:214653	20/79 (25%)
		Ig	394..463	CDD:143165	18/68 (26%)
		Ig_3	585..652	CDD:290638	16/75 (21%)
		Ig	685..>719	CDD:299845	10/43 (23%)
		IG_like	788..869	CDD:214653	5/80 (6%)
		Ig	<811..869	CDD:299845	5/57 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810