DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-II and igcm-1

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	914	Identity:	192/914 - (21%)
Similarity:	296/914 - (32%)	Gaps:	259/914 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 QEGDD-IVITCRV---VGGRPQPQVRW--LVNG---LLVDNQN---EHNSGDVIEN-------RL 231
            |||:: |||.|.|   ...|.:.::.|  ..||   ::..|..   :.:|..::||       .|
Worm    39 QEGNEGIVIPCVVKPEYFDRQKYEINWARYNNGQLRMITKNDKLLAKKHSRFILENDSATGNYSL 103

  Fly   232 LWPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPP----------SSMIADR 286
            ....|::|.:...:.|..:.|. |...:.|.:       ..|.:|.||          .|:|...
Worm   104 RITEVEKNSVEGTYHCNVIGTD-DSDVQYSAL-------ATVVVLVPPGDPIISTTPSESVIEGD 160

  Fly   287 RYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISKN----------STRSELSFVPTTDDDGKSI 341
            .....|.|.|..|....||       ....|.|:.:          :|.|.|.|..|:.|||||:
Worm   161 FMTAKCVSVGGSPQPTFTW-------TLPNDTIASSAIFTTQFRDGATESLLHFRVTSSDDGKSV 218

  Fly   342 TCRAENPNVNGLYLETMW----KLNVVYPPLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQWRK 402
            .|...|..:.|  .||..    :|||:|.|:|.:.....||...::||:.|...|:..|||....
Worm   219 QCDVTNRAMLG--GETKQVKSSQLNVLYKPVVFVTPTENLTHLSVEEGELVNLTCNSASNPPAHS 281

  Fly   403 LLWLHNGIHLEHNTSARVIRSNQSLVLQKITKHYAGNYACSAINDEGETVSNQLPLRVKYTPMCK 467
            ..|.|......:......||.:.|:         :|::.|.:.|:.||..: .|.:.|::.|...
Worm   282 YEWKHIASGERYQGKIWPIRVDSSM---------SGDFECRSTNELGEGTA-VLKMVVQHIPRIN 336

  Fly   468 HADRVILIGASKDETVEVVCEIQADPPPRTFRWKFNNSGETLDVGSERFSVNGSRSILKYTPVTD 532
            ..:.   |..::.|.::::||:.|.|.....:|          ||...|..||||  |..|.::.
Worm   337 VPES---ISPNEMEDIDILCEVSAVPEVIDIKW----------VGPNGFKQNGSR--LTITSISK 386

  Fly   533 QDYGTLSCWASN------EVGTQQH-------------PCLFQVVLAALPNAVSNCTVFNRTELS 578
            ...|..:|.|:|      ..|:||.             |...|:|     :|..|..|....:|.
Worm   387 AQSGNYTCMATNFLTVYGHSGSQQRMGTGTTIVDVKRKPGQAQIV-----SARQNVDVGETIKLM 446

  Fly   579 VDIQCIPGYDGGLPQIFVLEMFSTRTGITRFNLSNAEEALFSLENLDTLTSMMVQENNSLRLRIY 643
            ...:     |.|.|.........:..||  |.|....|..|.:.|      ..:.:|.     :|
Worm   447 CQAE-----DAGNPSASYTWASPSSGGI--FGLEGHTEKSFEVRN------AQLSDNG-----VY 493

  Fly   644 S---YNQKGRSAAYLLTDFIIGSTAYKTDDDVTLTLSPVIVGSVLTIIIIGVAIAI-----RIFV 700
            |   ||..|...                            :|:|:..:|....|:.     |||.
Worm   494 SCKAYNDLGEGK----------------------------IGTVMITVIEKARISSPLATERIFT 530

  Fly   701 VTFVHNLRRNRHHGSKATAAGVTAQ--PSDVFKGGNLEKPRWQ--HTDIKTKSSEDLVEDERDPD 761
                        .|.:.......||  ||.|.|.....:|..|  :....|..|:.|.||.....
Worm   531 ------------SGEQGKILECEAQGYPSPVIKWLKDGRPVKQSIYASSATSESKCLPEDFCTQT 583

  Fly   762 VIPSQYVGGSSAGSSGSNASNVGSTTAGTATGSSTSTAVV------------------ANANAAA 808
            |..:..:.|....|...|.:.|....:......|:|..:|                  |.|:..:
Worm   584 VASTLTLAGPLKWSDKGNFTCVADNGSDKTDKDSSSWTIVRVLHKPVFLNRKFPEKSLAAADIGS 648

  Fly   809 SAM------AGPGG------ATSSASATDGHQFASGTAAAGGGASKW------------------ 843
            .|:      |.|..      ..|..|..:.|.|  .|....|...::
Worm   649 QAIIRCKVSARPEPEFHWMFRDSEISENERHSF--HTVGITGKPDEYEQLLQIESVQESDYGEYV 711

  Fly   844 --SPNGN-----------VTTTMLTGDAVNATVTYNQINAQRAQLLAAVAAVGGGCSSTVISPSS 895
              :.|||           .:...|..|....:.|.|.:      ||..|....||...|.:..:.
Worm   712 CRATNGNGGDHVVIELRKTSPPALPLDLQKLSATSNSV------LLGWVPQFDGGADQTYVLETR 770

  Fly   896 SILGGLGKPLGMGMGMGLGMG-------VGGTVIGSP----TSLSSTATLAAHLQPAHSSGVGTL 949
            .|....|:..|......|.:.       :.||::...    |.|:..:|....:|.....|....
Worm   771 KIDPFTGEIDGNAPVSKLNINAVQQDQEIDGTLVSKNIFNFTGLTPLSTYNLRIQAVSEKGESEF 835

  Fly   950 PPGL 953
            .|.|
Worm   836 TPVL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653
		Ig	57..160	CDD:299845
		Ig	188..251	CDD:299845	18/81 (22%)
		Ig	289..363	CDD:299845	24/87 (28%)
		IG_like	289..351	CDD:214653	20/71 (28%)
		Ig_2	376..460	CDD:290606	20/83 (24%)
		IG_like	383..454	CDD:214653	17/70 (24%)
		Ig	470..548	CDD:299845	20/83 (24%)
		IG_like	481..557	CDD:214653	23/94 (24%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	16/73 (22%)
		Ig	146..226	CDD:299845	22/86 (26%)
		Ig_3	245..316	CDD:290638	18/79 (23%)
		IG_like	258..329	CDD:214653	18/80 (23%)
		IG_like	338..398	CDD:214653	19/74 (26%)
		IGc2	347..398	CDD:197706	18/62 (29%)
		Ig_2	429..513	CDD:290606	24/134 (18%)
		IG_like	437..513	CDD:214653	20/121 (17%)
		Ig	537..615	CDD:143165	18/77 (23%)
		IG_like	644..728	CDD:214653	13/85 (15%)
		IGc2	646..719	CDD:197706	11/74 (15%)
		FN3	733..843	CDD:238020	23/113 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810