Protein Alignment side-II and LOC1278969

DIOPT Version :10

• Sequence 1: NP_001400995.1
• Gene: side-II / 3346206
• FlyBaseID: FBgn0259213
• Length: 1067
• Species: Drosophila melanogaster
• Sequence 2: XP_061512275.1
• Gene: LOC1278969 / 1278969
• VectorBaseID: AGAMI1_012658
• Length: 898
• Species: Anopheles gambiae
• Alignment Length: 1093
• Identity: 488/1093 - (44%)
• Similarity: 628/1093 - (57%)
• Gaps: 285/1093 - (26%)

  Fly    45 ISSKDSHVKTK----DIDAVEGKSVSLPCPITEPLDNVYMVLWFRDNAGIPLYSFDVRDKESREQ 105
            |..|..|.|.|    .::.|||:||.|.||||.||..|||||||:|||||||||.|||||.|| |
Mosquito    21 IDGKSMHEKDKHDVFSVEGVEGRSVELHCPITVPLSQVYMVLWFKDNAGIPLYSVDVRDKISR-Q 84

  Fly   106 PRHWSAPEVFGSRAKFHFDSQPATLEIKDIKRHDQGIYRCRVDFRTSQTQSFRFNLSVIILPEQP 170
            |.||||||||||||||:.|..||:|.||::||||||:||||:||||.|||::|:|||||:|||||
Mosquito    85 PAHWSAPEVFGSRAKFNIDKSPASLLIKNLKRHDQGVYRCRIDFRTIQTQTYRYNLSVIVLPEQP 149

  Fly   171 IIMDRWGRQLNGTQLGPKQEGDDIVITCRVVGGRPQPQVRWLVNGLLVDNQNEHNSGDVIENRLL 235
            :::|||||.||||:||||:||||:||||||.||||||:||||:||::||:|.|.|||||||||||
Mosquito   150 VVLDRWGRHLNGTKLGPKEEGDDVVITCRVSGGRPQPEVRWLINGVIVDDQYEQNSGDVIENRLL 214

  Fly   236 WPSVQRNDLNSVFTCQALNTQLDKPKEKSFILDMHLKPLVVKILEPPSSMIADRRYEVSCESSGS 300
            ||::||:|||::||||.:||:|.:|||.|::||||||||.:|::.||::::||:|||:.|:|:||
Mosquito   215 WPTIQRSDLNAIFTCQTMNTKLVEPKETSYVLDMHLKPLTIKVINPPATLVADKRYEIVCQSTGS 279

  Fly   301 RPNAIITWYKGKRQLRRTKDD-ISKNSTRSELSFVPTTDDDGKSITCRAENPNVNGLYLETMWKL 364
            ||||||||||||||:|||:|: :..|:|.|.|||.|||:||||::||||||||||||:|||.||:
Mosquito   280 RPNAIITWYKGKRQMRRTRDETVDHNTTTSTLSFAPTTEDDGKTLTCRAENPNVNGLFLETDWKM 344

  Fly   365 NVVYPPLVTLRLGSTLTPDDIKEGDDVYFECHVQSNPQWRKLLWLHNGIHLEHNTSARVIRSNQS 429
            ||||||:||::||.||..|||||||||||||||::||.|::|.|.||.:.|::|.|||:|:|.||
Mosquito   345 NVVYPPMVTIQLGPTLVVDDIKEGDDVYFECHVRANPDWKRLQWFHNDVLLQYNGSARIIQSGQS 409

  Fly   430 LVLQKITKHYAGNYACSAINDEGETVSNQLPLRVKYTPMC---KHAD---------------RVI 476
            |||||:||..||.|||||||.||||||:|..||||:.|:|   :|..               ..|
Mosquito   410 LVLQKVTKQSAGYYACSAINAEGETVSDQQHLRVKHVPVCATERHGGNAPGGNGTDPSGSNRNAI 474

  Fly   477 LIGASKDETVEVVCEIQADPPPRTFRWKFNNSGETLDVGSERFSVNGSRSILKYTPVTDQDYGTL 541
            |||||::|.||:.|.|.||||.|:|.|:||||.|.|.|.:.|::..|:.|||.|.||||||:|||
Mosquito   475 LIGASRNENVEIPCHIFADPPARSFHWRFNNSAEILPVDAHRYTSQGNISILNYAPVTDQDFGTL 539

  Fly   542 SCWASNEVGTQQHPCLFQVVLAALPNAVSNCTVFNRTELSVDIQCIPGYDGGLPQIFVLEMFSTR 606
            :|||.||||.|..||.||:|||.||:.||||::.|||:...:|||.|||||||||:||||:.|.|
Mosquito   540 TCWAVNEVGPQSQPCTFQLVLADLPSPVSNCSLPNRTQQFAEIQCTPGYDGGLPQVFVLELVSKR 604

  Fly   607 TGITRFNLSNAEEALFSLENLDTLTSMMVQENNSLRLRIYSYNQKGRSAAYLLTDFIIGS----- 666
            ||..|||.||..|..|.|:.|:.|:::|..|||||...:|:.||||||...|:.||.||.
Mosquito   605 TGTRRFNFSNKNEPFFVLDRLEKLSALMTLENNSLSCVVYAINQKGRSTPVLIQDFEIGRIQPYR 669

  Fly   667 --TAYKTDDDVTLTLSPVIVGSVLTIIIIGVAIAIRIFVVTFVHNLRRNRHHGSKATAAG----- 724
              |..:.|   .:...|:.||.:||:||:.::|:.:.::              ::..|||
Mosquito   670 AVTERRAD---AIEWLPIAVGILLTVIILALSISTKTYL--------------NRCLAAGCCCRR 717

  Fly   725 ---VTAQPSDVFKGGNLEKPRWQHTDIKTKS--------------------------------SE 754
               .:|:.:|.......|:.: ||...:||:                                |:
Mosquito   718 CCAASAKRNDASASDKSEQQQ-QHQQQQTKNVLLPDEYECGAHCLKLKNVQMLRRHSSRKKNCSK 781

  Fly   755 DLVEDERDPDVIPSQYVGGSSAGSSGSNASNVGSTTAGTATGSSTSTAVVANANAAASAMAGPGG 819
            |..:||.:|||||:|:              |:.|.|...||...|..|
Mosquito   782 DSNDDEPEPDVIPAQF--------------NMVSCTPLIATPQHTDAA----------------- 815

  Fly   820 ATSSASATDGHQFASGTAAAGGGASKWSPNGNVTTTMLTGDAVNATVTYNQINAQRAQLLAAVAA 884
                |...|.||:...|          ||                ..||..
Mosquito   816 ----ARDKDAHQYGGFT----------SP----------------PATYKM-------------- 836

  Fly   885 VGGGCSSTVISPSSSILGGLGKPLGMGMGMGLGMGVGGTVIGSPTSLSSTATLAAHLQPAHSSGV 949
                                                 ||::.
Mosquito   837 -------------------------------------GTIVD----------------------- 841

  Fly   950 GTLPPGLGSGGGYILNAYASGRLHHPPGGGVPGGATHTATLNRHHHQQQQLHHHPHHQQPHHSGS 1014
                                   |||   .||             .|...|.:..|
Mosquito   842 -----------------------HHP---AVP-------------QQDTALEYRTH--------- 858

  Fly  1015 SLLMGSAGSVMGVVGSTTTATTSCNSSQDLDDNININAIKDCLMTQRVPESCV 1067
                   ||::|::  .|..|.:..::.:||    ||.|||.|:|.|||||||
Mosquito   859 -------GSIVGIL--PTARTAAAGAAAELD----INVIKDRLLTTRVPESCV 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001400995.1	V-set	55..163	CDD:462230	78/111 (70%)
		Ig_3	190..254	CDD:464046	48/63 (76%)
		Ig	<292..366	CDD:472250	53/74 (72%)
		Ig strand B	292..295	CDD:409418	1/2 (50%)
		Ig strand C	305..309	CDD:409418	3/3 (100%)
		Ig strand E	329..333	CDD:409418	2/3 (67%)
		Ig strand F	343..348	CDD:409418	2/4 (50%)
		Ig strand G	359..362	CDD:409418	2/2 (100%)
		Ig	382..457	CDD:472250	52/74 (70%)
		Ig strand B	391..395	CDD:409405	3/3 (100%)
		Ig strand C	405..409	CDD:409405	1/3 (33%)
		Ig strand E	428..432	CDD:409405	3/3 (100%)
		Ig strand F	442..447	CDD:409405	3/4 (75%)
		Ig	486..554	CDD:409353	41/67 (61%)
		Ig strand B	486..490	CDD:409353	2/3 (67%)
		Ig strand C	500..504	CDD:409353	1/3 (33%)
		Ig strand E	526..530	CDD:409353	3/3 (100%)
		Ig strand F	540..545	CDD:409353	3/4 (75%)
LOC1278969	XP_061512275.1	None