DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-II and MERTK

DIOPT Version :9

Sequence 1:	NP_001014485.3	Gene:	side-II / 3346206	FlyBaseID:	FBgn0259213	Length:	1064	Species:	Drosophila melanogaster
Sequence 2:	NP_006334.2	Gene:	MERTK / 10461	HGNCID:	7027	Length:	999	Species:	Homo sapiens

Alignment Length:	362	Identity:	83/362 - (22%)
Similarity:	140/362 - (38%)	Gaps:	71/362 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 LSFVPTTDDDGKSITCRAENPNVNGLYLETMWKLNVVYPPLVTLRLGSTLTPDDIKEGDDVYFEC 392
            |.|.||  ..|:..|.....|.|.          :|...||..|....|:....:.|...|.|.|
Human    63 LMFSPT--QPGRPHTGNVAIPQVT----------SVESKPLPPLAFKHTVGHIILSEHKGVKFNC 115

  Fly   393 HV-------QSNPQW----RKLLWLHNGI---HLEHNTSARVIRSNQSLVLQKITKHYAGNYACS 443
            .:       .:...|    ::||..|:.|   :.:...:|.:    .|..:..:.:...|:|.|.
Human   116 SISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAII----ASFSITSVQRSDNGSYICK 176

  Fly   444 -AINDEGETVSNQLPLRVKYTP-MCKHADRVILIGASKDETVEVVCEIQADPPPRTFRWKFNNSG 506
             .||:| |.||:.:.:.|:..| ..|..:.   :..:::....:.|:....|.|....|..|:|
Human   177 MKINNE-EIVSDPIYIEVQGLPHFTKQPES---MNVTRNTAFNLTCQAVGPPEPVNIFWVQNSS- 236

  Fly   507 ETLDVGSERFSVN----GSRSILKYTPVTDQDYGTLSCWASNEVGTQQHPCLFQVVLAALPNAVS 567
                      .||    .|.|:|....:|:.  ...||.|.|:.|......: |:.:.|:|:..:
Human   237 ----------RVNEQPEKSPSVLTVPGLTEM--AVFSCEAHNDKGLTVSKGV-QINIKAIPSPPT 288

  Fly   568 NCTVFNRTELSVDIQCIPGYDGGLP----QIFVLEMFSTRTG-ITRFNLSNAEEALFSLENLDTL 627
            ..::.|.|..|:.|..:||:||..|    .|.|.|......| :..||.| |...|:.::.|..|
Human   289 EVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTS-ALPHLYQIKQLQAL 352

  Fly   628 TSMMVQENNSLRLRIYSYNQKGRSAAYLLTDFIIGST 664
            .:..:        .:...|:.|.||   ::.:|:.||
Human   353 ANYSI--------GVSCMNEIGWSA---VSPWILAST 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-II	NP_001014485.3	IG_like	55..160	CDD:214653
		Ig	57..160	CDD:299845
		Ig	188..251	CDD:299845
		Ig	289..363	CDD:299845	8/34 (24%)
		IG_like	289..351	CDD:214653	7/22 (32%)
		Ig_2	376..460	CDD:290606	21/98 (21%)
		IG_like	383..454	CDD:214653	19/85 (22%)
		Ig	470..548	CDD:299845	16/81 (20%)
		IG_like	481..557	CDD:214653	17/79 (22%)
MERTK	NP_006334.2	IG	111..193	CDD:214652	19/86 (22%)
		Ig	111..176	CDD:143165	12/68 (18%)
		Ig2_Tyro3_like	199..279	CDD:143226	19/96 (20%)
		IG_like	203..280	CDD:214653	18/93 (19%)
		FN3	284..378	CDD:238020	26/105 (25%)
		FN3	386..478	CDD:238020
		PTKc_Mer	579..862	CDD:271106
		Pkinase_Tyr	587..854	CDD:285015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000