DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and Stk17b

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_598571.2 Gene:Stk17b / 98267 MGIID:2138162 Length:372 Species:Mus musculus


Alignment Length:353 Identity:106/353 - (30%)
Similarity:179/353 - (50%) Gaps:47/353 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  3143 RNIAGSISTSVTVHIE-ENEDQYIYKTYGRHPYVRSKQLRYQDKYDIGDELGRGTQGITYHAVER 3206
            |:::|.::|:....|: ||.:.:    |...|                .|||||...:....:.:
Mouse     9 RSVSGLLTTTPQTPIKTENFNNF----YTLTP----------------KELGRGKFAVVRQCISK 53

  Fly  3207 SSGDNYAAKIMYGR---PELRPFMLNE---LEMMNTFNHKNLIRPYDAYDTDRSVTLIMELAAGG 3265
            |:|..||||.:..|   .:.|..:|:|   ||:..:..|  :|..::.|:....:.|::|.||||
Mouse    54 STGQEYAAKSLKKRRRGQDCRAEILHEIAVLELARSCPH--VINLHEVYENATEIILVLEYAAGG 116

  Fly  3266 ELVRDNLL---RRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVG--GDIIKVS 3325
            |:.  ||.   ..:..:|.|:...|:|.|.|:.::|:..:.|:.|..:::|:|.:.  || ||:.
Mouse   117 EIF--NLCLPELAEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSIYPLGD-IKIV 178

  Fly  3326 DFGLSRKINRHNLSTLD--YGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLGIDDR 3388
            |||:||||.  |.|.|.  .|.||:::||::|.:.:..:.|||.:|:|.|:||...:||:|.|::
Mouse   179 DFGMSRKIG--NASELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQ 241

  Fly  3389 ETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKTALKHPWFFMLDRPVYDH--- 3450
            ||...|.:...|:.:|:::.:|....|||..||:.:||:|...::.|.|.|....|.....|   
Mouse   242 ETYLNISQVNVDYSEEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQQWDFGSLFHPEE 306

  Fly  3451 ---DYQIGTDRLRNYYDHFRDWYANASC 3475
               ..||....||:..:.......|.||
Mouse   307 TSGSSQIQDLTLRSSEEKTSKSSCNGSC 334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352
I-set 1599..1690 CDD:333254
I-set 1694..1786 CDD:254352
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254 3/13 (23%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 88/270 (33%)
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
Stk17bNP_598571.2 STKc_DRAK2 24..293 CDD:271100 92/295 (31%)
S_TKc 37..293 CDD:214567 88/262 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..348 7/30 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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