DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and SESTD1

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_835224.3	Gene:	SESTD1 / 91404	HGNCID:	18379	Length:	696	Species:	Homo sapiens

Alignment Length:	769	Identity:	137/769 - (17%)
Similarity:	242/769 - (31%)	Gaps:	283/769 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1013 SVDKPVVVKMLKSV---------QVEPGE-----TAHFEIQFKDQPGLVTWLKDNKPLEDRLADR 1063
            :|.|.||| ||::|         .|:|.|     ..||          ..|.:     :|||...
Human    75 NVVKTVVV-MLQNVVPAEVSLVCVVKPDEFWDKKVTHF----------CFWKE-----KDRLGFE 123

  Fly  1064 ITQTAAPMNSYRLDIKNCSETD--AGTYT-----------IRAQSASETTTVSAQLAV---GQAP 1112
            :...:|  |.....|:.|..|:  .|:.|           :..:...|:|::..:||:   |...
Human   124 VILVSA--NKLTRYIEPCQLTEDFGGSLTYDHMDWLNKRLVFEKFTKESTSLLDELALINNGSDK 186

  Fly  1113 GHDETK-TNTEPAFLVSLKDAEMIENT----LFRFMVKIIGDPKPRVKFYKDEKEILETNDRIQI 1172
            |:.:.| .:.:..||.|: |.|.:..|    |.....:........|.:...:.|:|.....:::
Human   187 GNQQEKERSVDLNFLPSV-DPETVLQTGHELLSELQQRRFNGSDGGVSWSPMDDELLAQPQVMKL 250

  Fly  1173 IRD--KDYLGFYELVIADVQKTDAGTYSCKATNKHGEANCEAIATTVEDKNPFGALSGQILPAGE 1235
            :..  :.|..:.|:              |:..:|  ....|.|...|  ......|.|   |..|
Human   251 LDSLREQYTRYQEV--------------CRQRSK--RTQLEEIQQKV--MQVVNWLEG---PGSE 294

  Fly  1236 KPVFQW------------KRNGEEFDPE--ERFKVLF------------GEDEDSLALVFQHVKP 1274
            :...||            ::..||.:.:  |.|.|..            |::||.:.|.....:.
Human   295 QLRAQWGIGDSIRASQALQQKHEEIESQHSEWFAVYVELNQQIAALLNAGDEEDLVELKSLQQQL 359

  Fly  1275 EDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKGF 1339
            .|. .|...:|.........|.|...|..|.|:::.:                  .:|.:.|...
Human   360 SDV-CYRQASQLEFRQNLLQAALEFHGVAQDLSQQLD------------------GLLGMLCVDV 405

  Fly  1340 PKPAVQWKHDGEVIQVDDRHKFMYEDEESMSLVIKNVDTVDAGVYTIEAINELGQDESSINLVVK 1404
             .||     ||..||            :::.|:.:.:.:||.|   ::.:.|.||.
Human   406 -APA-----DGASIQ------------QTLKLLEEKLKSVDVG---LQGLREKGQG--------- 440

  Fly  1405 APPKIKKITDITCSAGETIKMEIEVEGFPQPTVQVTNN-----GKDVTAESNVKI-------SSS 1457
                   :.|                       |::|.     |||||.|:...:       ...
Human   441 -------LLD-----------------------QISNQASWAYGKDVTIENKENVDHIQGVMEDM 475

  Fly  1458 SIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYWSCTV---------------KSKPVIV 1507
            .:.|...:.:|:|:.:|:.|.... .|...|.:|..|:.|..:               ::|.::.
Human   476 QLRKQRCEDMVDVRRLKMLQMVQL-FKCEEDAAQAVEWLSELLDALLKTHIRLGDDAQETKVLLE 539

  Fly  1508 KN------FESEYIHGEKENVQMTVRI------------DAYPEAKLTWYHDETEIKITDSKYTV 1554
            |:      .:|.|.:| ::.:|.||.:            |..|.....|           .::|:
Human   540 KHRKFVDVAQSTYDYG-RQLLQATVVLCQSLRCTSRSSGDTLPRLNRVW-----------KQFTI 592

  Fly  1555 SSDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVEL 1619
            :|:...:.|::..|...:|.|.......|..:.....|.             :...|.|.|.::.
Human   593 ASEERVHRLEMAIAFHSNAEKILQDCPEEPEAINDEEQF-------------DEIEAVGKSLLDR 644

  Fly  1620 VVGVDAYPRPHAKWYIDGIE----------------------IDEKRNDFRHVE 1651
            :.....||        ||.|                      ::.||...||.|
Human   645 LTVPVVYP--------DGTEQYFGSPSDMASTAENIRDRMKLVNLKRQQLRHPE 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285
		TonB_N	502..>596	CDD:318287
		I-set	1017..1108	CDD:333254	25/117 (21%)
		I-set	1123..1212	CDD:254352	14/94 (15%)
		I-set	<1236..1299	CDD:333254	16/88 (18%)
		I-set	1313..1403	CDD:254352	15/89 (17%)
		Ig_3	1406..1487	CDD:316449	15/92 (16%)
		I-set	1499..1595	CDD:254352	19/128 (15%)
		I-set	1599..1690	CDD:333254	13/75 (17%)
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
SESTD1	NP_835224.3	CRAL_TRIO_2	33..153	CDD:404584	24/95 (25%)
		SPEC	273..478	CDD:413338	50/288 (17%)
		Spectrin 1	275..378		21/108 (19%)
		Spectrin 2	381..494		32/190 (17%)
		SPEC	413..605	CDD:413338	42/258 (16%)
		Spectrin 3	500..602		18/113 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900