DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and IGFN1

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_001158058.1 Gene:IGFN1 / 91156 HGNCID:24607 Length:3708 Species:Homo sapiens


Alignment Length:921 Identity:202/921 - (21%)
Similarity:323/921 - (35%) Gaps:270/921 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1517 GEKENVQMTVRIDAYPEAKLTWYHDETEIKITDSKYTVSSDGNAYTLKITGATRVDAGKYTVKAT 1581
            ||...:..|:..|..|.   ||:.|..::...|. .....||..::|.||......||:||..|.
Human  2927 GEAATLSCTLTSDLGPG---TWFKDGVKLTTQDG-VIFKQDGLVHSLFITHVQGTQAGRYTFVAG 2987

  Fly  1582 NEHGSATSSTQLLIKCAPEFTHKLKNITVAEGDSNVELVVGVDAYPRPHAKWYIDGIEIDEKRND 1646
            ::...||.:.|.....||:.|.||:...|.:....|.:.:...::....|.|..||.|:....:.
Human  2988 DQQSEATLTVQ
DSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEVVGSSDR 3052

  Fly  1647 FRHVEEGNDF-KLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQE--- 1707
            ...|:.|:.: :|.:........|.|:..:.::.|.::....:.|..||...:|  .:|||:   
Human  3053 EAQVDLGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQG--PMEVQDCHR 3115

  Fly  1708 --------------GKSFTLEVEVYSEPEA-KIKWFKDGH-----EIYEDARIKISRDTQRIENY 1752
                          |:  |:|..|....:| :..|.|.|.     ..:.||.::..|      .|
Human  3116 AGVCLRWRPPRDNGGR--TVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPGR------KY 3172

  Fly  1753 YLTLNLARTEDAG----TYE-MKATNFIGETTSTCKVAVLTSEALSLEQTV-------------- 1798
            ...:....:|.||    :.| :.|...:.:..|...:...:|:.::|..|.              
Human  3173 TFRVRAVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLI 3237

  Fly  1799 ------TKTLIATTEEPEEGAVPE--IVHVDVFQQHSYESVPLKYEVIAT-----GIPKP--EAI 1848
                  :.|..|..::|    |||  ....||.|...||     :.|.|.     |.|.|  :|:
Human  3238 ERRKKGSNTWTAVNDQP----VPERRWTVADVRQGCQYE-----FRVTAVAPSGPGEPGPPSDAV 3293

  Fly  1849 WYHDG-KP--------ITPDKHTAITV--------DGDH---YKLEVQSLDLVD----------- 1882
            :..|. :|        :|...:|:||:        :||.   |.:|:.|.|.:.           
Human  3294 FARDPMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQWLPCHVGTVPV 3358

  Fly  1883 ---------AGEYKVVVQNKVGEKSHQGELSLSGIAEYRK----PILTQGPGLKD-IKVNKGDKV 1933
                     .||...|....|.|.......:|..:.:...    |........|| :.|..||.|
Human  3359 TTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTVKVGDTV 3423

  Fly  1934 CEPVVFTADPAPEIVLLKDGQPVVETNNVKLKVDKKDAENGLVQYTCTLNILEAEIKDSGRYELK 1998
            ..||.|.|.|.||:..||||.|:.:.:....|       :||.|    |.|..|.:.|||.|.:.
Human  3424 RVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTK-------DGLTQ----LLIPVAGLSDSGLYTVV 3477

  Fly  1999 VKNKYG-ELVTSGWIDVLAKPEISG-LNDTKCLPGDTICFEALVQANPKPKVSWTRGNENLCNHE 2061
            ::...| |:..|..|.|.|.|:..| ::..:.:||                              
Human  3478 LRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPG------------------------------ 3512

  Fly  2062 NCEVIADVDADKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQPESQSIHD 2126
                                        |:||   |...:.|                |:|.:..
Human  3513 ----------------------------TVTA---EWEPSPD----------------EAQDVPL 3530

  Fly  2127 YRPVSTKVLVHGVPLPTIEWFKDDKPINYEAINKPGKDKLYAKEDTKKGTDQIESVLDIKSFREN 2191
            :..|.|:...||      .|        :||     .|:::....|..|      :|....:.  
Human  3531 HYAVFTRSSAHG------PW--------HEA-----ADRIHTNRFTLLG------ILPGHEYH-- 3568

  Fly  2192 DVGAYTCVATNEIGVT--------------------KAP-FKLAMLSLAPSFVKKLDNALDVLQG 2235
                :..||.||:|.:                    ||| ::...||..|.|:..|.:.| :.||
Human  3569 ----FRVVAKNELGASKPSDTSQPWCIPRQRDRFTVKAPCYREPDLSQKPRFLVGLRSHL-LPQG 3628

  Fly  2236 EPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKISTNPDGLVKLEINSCQPNDSGAYKLIISNPH 2300
            ....:.|.|.|||.|.|.|.|:...::.:.:: .||:..|:..|.|.|..|.|||.||.:..|..
Human  3629 CECCMSCAVQGSPRPHVTWFKNDRSLEGNPAV-YSTDLLGVCSLTIPSVSPKDSGEYKAVAENTL 3692

  Fly  2301 GEKVALCAVAV 2311
            |:.|:...:.|
Human  3693 GQAVSTATLIV 3703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449
I-set 1499..1595 CDD:254352 22/77 (29%)
I-set 1599..1690 CDD:333254 17/91 (19%)
I-set 1694..1786 CDD:254352 23/119 (19%)
I-set <1836..1903 CDD:333254 23/113 (20%)
I-set 1922..2005 CDD:333254 30/84 (36%)
I-set 2018..2108 CDD:333254 9/90 (10%)
I-set 2113..2214 CDD:333254 21/121 (17%)
I-set 2220..2302 CDD:254352 28/81 (35%)
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
IGFN1NP_001158058.1 I-set 29..120 CDD:254352
Ig 46..120 CDD:299845
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 61..81
I-set 309..395 CDD:254352
I-set 2914..2997 CDD:254352 21/73 (29%)
Ig 2930..2998 CDD:143165 19/71 (27%)
I-set 3005..3097 CDD:254352 17/91 (19%)
Ig 3017..3104 CDD:299845 15/86 (17%)
FN3 3101..3193 CDD:238020 20/101 (20%)
FN3 3201..3278 CDD:238020 16/85 (19%)
FN3 3302..3388 CDD:238020 15/85 (18%)
IG_like 3415..3494 CDD:214653 31/89 (35%)
Ig 3422..3494 CDD:299845 28/82 (34%)
FN3 3498..3587 CDD:238020 27/196 (14%)
I-set 3614..3703 CDD:254352 30/90 (33%)
Ig 3633..3700 CDD:143165 24/67 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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