DRSC/TRiP Functional Genomics Resources

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Protein Alignment Unc-89 and KALRN

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:XP_006713873.1 Gene:KALRN / 8997 HGNCID:4814 Length:2988 Species:Homo sapiens


Alignment Length:3164 Identity:603/3164 - (19%)
Similarity:1037/3164 - (32%) Gaps:994/3164 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1474 KLSQAGNYSIKATNDLS-QTSEYW---SCTVKSKPVIVKNFESEYIHGEKENVQMTVRIDAY--- 1531
            :||:||:|:.:....:| |..:.|   :..:..:..|:.  .|...|.:.|  |....:||:   
Human   379 RLSEAGHYASQQIKQISTQLDQEWKSFAAALDERSTILA--MSAVFHQKAE--QFLSGVDAWCKM 439

  Fly  1532 ----------PEAKLTWYHDETEIKITDSKYT-VSSDGNAYTLKITGATRVDAGKYTVKATNEHG 1585
                      .:.:|..:|.:|..:.....|| ||.||.| .|.:...........::.||..:.
Human   440 CSEGGLPSEMQDLELAIHHHQTLYEQVTQAYTEVSQDGKA-LLDVLQRPLSPGNSESLTATANYS 503

  Fly  1586 SATSSTQLLIKCAPEFTHKLKNITVAEGDSNVEL-------VVGVDAYPRPHAKWYIDGIEIDEK 1643
            .|...   ::....|..|..:.:........|.|       |...|      .:..:|.||...:
Human   504 KAVHQ---VLDVVHEVLHHQRRLESIWQHRKVRLHQRLQLCVFQQD------VQQVLDWIENHGE 559

  Fly  1644 RNDFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKLEDNCVVTVNCKPKVKRGLKNVEVQEG 1708
            ....:|...|...     ..|..:|     |..:|:.::..|.....:         |.:|..|.
Human   560 AFLSKHTGVGKSL-----HRARALQ-----KRHDDFEEVAQNTYTNAD---------KLLEAAEQ 605

  Fly  1709 KSFTLEVEVYSEPEAKIKWFKDGHEIYEDAR---IKISRDTQRIENYYLTLNLA-----RTEDAG 1765
            .:.|.|    .:||          |||:.||   ::|....:|:|...|.|:::     .|::..
Human   606 LAQTGE----CDPE----------EIYKAARHLEVRIQDFVRRVEQRKLLLDMSVSFHTHTKELW 656

  Fly  1766 TYEMKATNFIGETTSTCKVAVLTSEALSLEQTVTKTLIATTEEPEEGAVPEIVHVDVFQQHSYES 1830
            |:.......:.|......|..:.......:|..|.||.||....:||.       |:.||     
Human   657 TWMEDLQKEMLEDVCADSVDAVQELIKQFQQQQTATLDATLNVIKEGE-------DLIQQ----- 709

  Fly  1831 VPLKYEVIATGIP---KPEAIWYHDGKPITPDKHTAITVDGDHYKLEVQSLDLVDAGEYKVVVQN 1892
              |:....:.|.|   :..|:  .:.|  ||...:.     .|.:..:|.||  ||       |.
Human   710 --LRSAPPSLGEPSEARDSAV--SNNK--TPHSSSI-----SHIESVLQQLD--DA-------QV 754

  Fly  1893 KVGEKSHQGELSLSGIAEYRKPILTQGPGLKDIKVNKGDKVCEPVVFTADPAPEI-----VLLKD 1952
            ::.|..|:.::.|....:.|  |..|                    :|.:...|:     .||: 
Human   755 QMEELFHERKIKLDIFLQLR--IFEQ--------------------YTIEVTAELDAWNEDLLR- 796

  Fly  1953 GQPVVETNNVKLKVDKKDAENGLVQYT---CTLNILEAEI----KDSGRYELKVKNKYGELVTSG 2010
                 :.|:...: |...||..|.::|   ..:|.:..|:    :|..:|..:|:....||:...
Human   797 -----QMNDFNTE-DLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYITEVQASGIELICEK 855

  Fly  2011 WIDVLAKP--------------EISGLNDTKCLPGDTICFEAL-VQANPKPKVSWTRGNENLCNH 2060
            .||:.|:.              |::.....|.|..   |.:.. :||..|..:.|.|..|::.|.
Human   856 DIDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQ---CLQLRHLQAEVKQVLGWIRNGESMLNA 917

  Fly  2061 E--NCEVIADVDA-----DKYRLVFQSVSPCEDGKYTITATNSEGRAAVDFNLAVLVEKPTFIVQ 2118
            .  |...:::.:.     ::::|..:|:       :..|:.....::|:.     :.:|...::|
Human   918 SLVNASSLSEAEQLQREHEQFQLAIESL-------FHATSLQKTHQSALQ-----VQQKAEVLLQ 970

  Fly  2119 PESQSIHDYRPVSTKVLVHGVPL------------PTIEWFKDDKPI--NYEAINKP-------- 2161
            .........|..:.||.:|...|            .::.::|..:.:  ..|::.:.        
Human   971 AGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDWC 1035

  Fly  2162 -GKDKL--YAKED-----TKKGTDQIESVLD------------IKSFRENDVGAYTCVATNEIGV 2206
             |:|||  .|:.|     ..|..:|.|:.|.            :|....|:| :...||::    
Human  1036 GGRDKLGPAAEIDHVIPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNV-SMPSVASH---- 1095

  Fly  2207 TKAPFK--LAMLSLAPSFVKKLDNALDVLQGEPLVLECCVDGSPLPTVQWLKDGDEVKPSESIKI 2269
            |:.|.:  .|:||             ::||.|..||..           |.              
Human  1096 TRGPEQQVKAILS-------------ELLQRENRVLHF-----------WT-------------- 1122

  Fly  2270 STNPDGLVKLEINSCQP---------------NDSGAYKLIISNPHGEKVALCAVAVKPEEMQP- 2318
                  |.|..::.||.               .::|.:.|......||..         ||.|. 
Human  1123 ------LKKRRLDQCQQYVVFERSAKQALDWIQETGEFYLSTHTSTGETT---------EETQEL 1172

  Fly  2319 -----KFLKPITSQTVVVGEPLKLEAQVTG-------FPAPEV-KW-------YKDGML------ 2357
                 :|..| ..||   .|.:||..|:..       ..|.|: ||       |:|..|      
Human  1173 LKEYGEFRVP-AKQT---KEKVKLLIQLADSFVEKGHIHATEIRKWVTTVDKHYRDFSLRMGKYR 1233

  Fly  2358 --LRPSPEINFINSPNGQIGLIIDAAQPLDAGVYKCLIANKGGEI-----EGVSKVEIVPKE--- 2412
              |..:..:|..::.:.::.:|     |......:..:.:...|:     :...|.|.:..|   
Human  1234 YSLEKALGVNTEDNKDLELDII-----PASLSDREVKLRDANHEVNEEKRKSARKKEFIMAELLQ 1293

  Fly  2413 SKPVFVAELQD---------ASSIEGFP---VKMDIKVVGNPKPKLQWFHNG---------HEIK 2456
            ::..:|.:|.:         .|.:|..|   :..:..:.||.: ::..|||.         .::.
Human  1294 TEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNIQ-EIYDFHNNIFLKELEKYEQLP 1357

  Fly  2457 PDASH------------IAIVENPDNSSSLIIEKTAPGDSGLYEVIAQNPEGSTASKAKLYVAP- 2508
            .|..|            :...:|..:|:.||:|     .:|.:....|...|...|.:...:.| 
Human  1358 EDVGHCFVTWADKFQMYVTYCKNKPDSNQLILE-----HAGTFFDEIQQRHGLANSISSYLIKPV 1417

  Fly  2509 ----------KADETATEEAPQFVSALRDVNADEGQELVLSAPFISNPMPEV------------- 2550
                      |...|..||..   ..|:|     |.|::||.|..:|....|             
Human  1418 QRITKYQLLLKELLTCCEEGK---GELKD-----GLEVMLSVPKKANDAMHVSMLEGFDENLDVQ 1474

  Fly  2551 ----------IWSKDGVTLTPNERLLMTCDGKHIGLTIKPAEAADSGNYTCLLANPLGEDSSACN 2605
                      :|....:.....||.|...:   |.|... .|..||..:|               
Human  1475 GELILQDAFQVWDPKSLIRKGRERHLFLFE---ISLVFS-KEIKDSSGHT--------------- 1520

  Fly  2606 ANVRKVYKPPVFTQKISDQQQVFGNNAKIPVTVSGVPYPD-------------LEW------YFQ 2651
               :.|||..:.|.::...:.|.|:..|..:.....|..|             .||      ..|
Human  1521 ---KYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVIQ 1582

  Fly  2652 DKPI---------------PKSEKYSIKNDGDHHMLIVNNCEKGDQGVYK----CIASNREGKDI 2697
            ::.|               |..::.:.|.||      |.:.:....|..:    .|||......:
Human  1583 ERIIHLKGALKEPLQLPKTPAKQRNNSKRDG------VEDIDSQGDGSSQPDTISIASRTSQNTV 1641

  Fly  2698 TQGRLD-------IVNEIKKHSRSEPPVFL-----------KKIGDCDI--------YEGMVAKF 2736
            ...:|.       ::.:......||..:.:           ::.|.|.:        .||:|...
Human  1642 DSDKLSGGCELTVVLQDFSAGHSSELTIQVGQTVELLERPSERPGWCLVRTTERSPPLEGLVPSS 1706

  Fly  2737 TACAT-GYPEPEVEWFKNDQKLFP--SDRFLIDIEPNGLLRLTIKNVTEYDVGRYSCRIFNPYGD 2798
            ..|.: .....|::.|      ||  .|.:......||....::.|:                  
Human  1707 ALCISHSRSSVEMDCF------FPLVKDAYSHSSSENGGKSESVANL------------------ 1747

  Fly  2799 DICHAELFYDSLDSQQKPLEDQYT-------------------DFKKYKK---------SGAPPP 2835
               .|:...:|:.|...|.....|                   :.||.||         .|:|.|
Human  1748 ---QAQPSLNSIHSSPGPKRSTNTLKKWLTSPVRRLNSGKADGNIKKQKKVRDGRKSFDLGSPKP 1809

  Fly  2836 LSEGPIISRMTDRGLLLSWNPSVPLTPRY-PITYQIEMMDL-PEGD--------WRTLRTGVRSC 2890
            ..|........|......|....|....: |:...:::.|. |..|        .|...|.|.:.
Human  1810 GDETTPQGDSADEKSKKGWGEDEPDEESHTPLPPPMKIFDNDPTQDEMSSSLLAARQASTEVPTA 1874

  Fly  2891 ACDIRNLEPFRDYRFRVRVENKFGVSDPSPYTQTYRQKLVPDPPKTYTYLPPGTDFRPETSPYFP 2955
            |..:..:|..        |:||..:...|     ||..| .||...   |..|  ..|.|.|   
Human  1875 ADLVNAIEKL--------VKNKLSLEGSS-----YRGSL-KDPAGC---LNEG--MAPPTPP--- 1917

  Fly  2956 KDFDIERPPHDGLAQA---PQFLLREQDISYGVKDHNTELMWFVYGYPKPKMTYYFDDMLIESGG 3017
                 :.|..:..|:|   ..|:|.|  :....||:..:|...|.|:.|         .:.|.|.
Human  1918 -----KNPEEEQKAKALRGRMFVLNE--LVQTEKDYVKDLGIVVEGFMK---------RIEEKGV 1966

  Fly  3018 RFDQSYTRNGQATLF--INKMLDRDVGWYEAVATNEHGEARQRVRLEIAEHPRFLKRPDETFIMA 3080
            ..|.   |.....:|  |:::.|    |::              ...:||..:.::..|....:.
Human  1967 PEDM---RGKDKIVFGNIHQIYD----WHK--------------DFFLAELEKCIQEQDRLAQLF 2010

  Fly  3081 RKNGRIEAKLVGIPLPEVH---WFKDWKPIVDSSRIKISSYDPDIYVLSIHDSIIKDGGLYSISA 3142
            .|:.|           ::|   |:...||..:             |:::.:|:..::        
Human  2011 IKHER-----------KLHIYVWYCQNKPRSE-------------YIVAEYDAYFEE-------- 2043

  Fly  3143 RNIAGSISTSVTVHIEENEDQYIYKTYGR---HPYVRSKQLRYQDKYDIGDELGRGTQGITYHAV 3204
              :...|:..:|:      ..::.|...|   :..:....|||.:|           .|:....:
Human  2044 --VKQEINQRLTL------SDFLIKPIQRITKYQLLLKDFLRYSEK-----------AGLECSDI 2089

  Fly  3205 ERSSGDNYAAKIMYGRPELRPFMLN---------------ELEMMNTFNHKNLIRPYDAYDTDRS 3254
            |:      |.::|...|:....|:|               :|...:||....|.....:...:|.
Human  2090 EK------AVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERR 2148

  Fly  3255 VTLIMELAAGGELVRDNLLRRDYYTERDIAHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGG 3319
            |.|..::....||:|...|...|..:|.|                                    
Human  2149 VFLFEQIVIFSELLRKGSLTPGYMFKRSI------------------------------------ 2177

  Fly  3320 DIIKVSDFGLSRKINRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFLG 3384
                        |:|            ..|..|.|:.:...|:                      
Human  2178 ------------KMN------------YLVLEENVDNDPCKFA---------------------- 2196

  Fly  3385 IDDRETLTKI--REGRWDFKDEIW----THISDDGRDFISRLLLYSPEE--RMDVKTALKHPWFF 3441
            :.:|||..::  :....|.: :.|    ..:.:..|||::  .|.||.|  |.:..||:      
Human  2197 LMNRETSERVVLQAANADIQ-QAWVQDINQVLETQRDFLN--ALQSPIEYQRKERSTAV------ 2252

  Fly  3442 MLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKNYFRRRRLSGCFQHPSKMVYPP-GHVYTPE 3505
            |..:|.          ||           ..||.:.|         ...|:....|| |..|.| 
Human  2253 MRSQPA----------RL-----------PQASPRPY---------SSVPAGSEKPPKGSSYNP- 2286

  Fly  3506 NTPEPLPEPRIRAKREEVVSKYLHP--------DYELGLIQSESHYQYGPDTYLLQLRDVNFPVR 3562
                |||..:|.........:|..|        ..:||.....|......|.|.|:..::  .|.
Human  2287 ----PLPPLKISTSNGSPGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIKDYYALKENEI--CVS 2345

  Fly  3563 LREYMKV--------------AHRRSPSFALNDSVDWSLPVIRERRRFTDIMDEEIDDE------ 3607
            ..|.::|              |...||  |....|..|:.....:....:..|..|...      
Human  2346 QGEVVQVLAVNQQNMCLVYQPASDHSP--AAEGWVPGSILAPLTKATAAESSDGSIKKSCSWHTL 2408

  Fly  3608 --RTRSRISMYAANESYSIRRLRTELGPRL-------DEYTEADAM-IETQREGYPPFFREKPQT 3662
              |.|:.:.....||:...|:.:..||.::       .|.:|.|.: ..|..|...|.|      
Human  2409 RMRKRAEVENTGKNEATGPRKPKDILGNKVSVKETNSSEESECDDLDPNTSMEILNPNF------ 2467

  Fly  3663 IAITENQPSH----------------IHCFAVGDPKPCVQWFKNDMVLTE----SKRIKISVDED 3707
              |.|..|..                :.|...|.|||.:.|...|..:.:    |....:|..:.
Human  2468 --IQEVAPEFLVPLVDVTCLLGDTVILQCKVCGRPKPTITWKGPDQNILDTDNSSATYTVSSCDS 2530

  Fly  3708 GRSILRFEPALHFDVGVYKVVARNKVGQTVARCRIVVATLPDAPDSPEISANSGTEILLRWKQPR 3772
            |...|:....:..|.|:|..:|.|..|.|.....:.|..:|.||:.|.....|.|.::|||..|.
Human  2531 GEITLKICNLMPQDSGIYTCIATNDHGTTSTSATVKVQGVPAAPNRPIAQERSCTSVILRWLPPS 2595

  Fly  3773 DDGHSTVLCYSLQYKLSNCDAW-TTVADNIDHEFYLLHDLQPNTNYQFRLASKNRIGWSEMGIPV 3836
            ..|:.|:..|:::|:......| .:||..:| .:.::.||.|...||||:::.|..|   :.:|.
Human  2596 STGNCTISGYTVEYREEGSQIWQQSVASTLD-TYLVIEDLSPGCPYQFRVSASNPWG---ISLPS 2656

  Fly  3837 SASTVGGDAPKIHITKAMKHLQQLTENGHQVVPEEERVHTDYHCEREPPNWVTDSSVSDKYSFIS 3901
            ..|                ...:|.|             .|...:....:|  ..:....|:.::
Human  2657 EPS----------------EFVRLPE-------------YDAAADGATISW--KENFDSAYTELN 2690

  Fly  3902 EIARGEFSTIVKGIQKSTDTVVVAKILEVTDENEDNVVAEFDNFKTLRHERIPALFSAYKPLNVP 3966
            ||.||.||.:.|.|.|:|...|..|.:....:.::....|....:.|:|.:...|...|:.   |
Human  2691 EIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITLHDTYES---P 2752

  Fly  3967 IA-IFVMEKLQGADVLTYFSSRHEYSEQMVATVVTQLLDALQYLHWRGYCHLNIQPDNVVM-ASV 4029
            .: |.::|.:....:|.|..:..|..|:.||..:..:::||||||.....||:|:|:|::: ..:
Human  2753 TSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRI 2817

  Fly  4030 RSIQVKLVDFGSAKKVNKLGMKVTPCGSLDFQPPEMINDEPIFPQSDIWSLGALTYLLLSGCSPF 4094
            ...:|||:|...|.:::.........|:.:|..||:|...|:...:||||:|.|||::|||.|||
Human  2818 PVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAAPEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPF 2882

  Fly  4095 RGADEYETKQNISFVRYRF-ENLFKEVTPEATRFIMLLFKRHPTKRPYTEDCLEHRWLMSSDYMV 4158
            ....:.||..|:..|.:.| ...|..|:..|..||.::.:....:||....||:|.||...:...
Human  2883 LDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQEDFRRRPTAATCLQHPWLQPHNGSY 2947

  Fly  4159 RKRERAIFLG-SRLKTFCD---EYHDLKNASATSSKVLNTVAGG 4198
            .|    |.|. |||..|.:   ..:|::......|.::|.|..|
Human  2948 SK----IPLDTSRLACFIERRKHQNDVRPIPNVKSYIVNRVNQG 2987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091
PH_unc89 275..388 CDD:270134
Atrophin-1 <493..690 CDD:331285
TonB_N 502..>596 CDD:318287
I-set 1017..1108 CDD:333254
I-set 1123..1212 CDD:254352
I-set <1236..1299 CDD:333254
I-set 1313..1403 CDD:254352
Ig_3 1406..1487 CDD:316449 5/12 (42%)
I-set 1499..1595 CDD:254352 21/109 (19%)
I-set 1599..1690 CDD:333254 16/97 (16%)
I-set 1694..1786 CDD:254352 21/99 (21%)
I-set <1836..1903 CDD:333254 15/69 (22%)
I-set 1922..2005 CDD:333254 15/94 (16%)
I-set 2018..2108 CDD:333254 16/111 (14%)
I-set 2113..2214 CDD:333254 25/144 (17%)
I-set 2220..2302 CDD:254352 12/96 (13%)
I-set 2318..2408 CDD:254352 21/123 (17%)
I-set 2415..2506 CDD:254352 21/123 (17%)
I-set 2519..2608 CDD:254352 19/111 (17%)
I-set 2615..2696 CDD:254352 19/118 (16%)
I-set 2717..2805 CDD:254352 15/109 (14%)
FN3 2834..2925 CDD:238020 18/100 (18%)
I-set <2996..3063 CDD:333254 11/68 (16%)
I-set 3067..3157 CDD:333254 11/92 (12%)
PK_Unc-89_rpt1 3182..3440 CDD:271011 44/280 (16%)
I-set 3654..3744 CDD:333254 23/109 (21%)
FN3 3748..3840 CDD:238020 28/92 (30%)
STKc_Unc-89_rpt2 3893..4151 CDD:271014 78/260 (30%)
KALRNXP_006713873.1 SEC14 41..179 CDD:214706
SPEC 192..412 CDD:238103 8/32 (25%)
SPEC 313..538 CDD:238103 33/166 (20%)
SPEC 539..768 CDD:238103 60/299 (20%)
SPEC 893..1131 CDD:238103 49/298 (16%)
SPEC <1101..1240 CDD:295325 36/195 (18%)
RhoGEF 1286..1456 CDD:238091 34/183 (19%)
PH1_Kalirin_Trio_like 1463..1585 CDD:270060 22/143 (15%)
PH 1496..1581 CDD:278594 20/106 (19%)
SH3_Kalirin_1 1651..1710 CDD:212786 7/58 (12%)
SH3-RhoG_link 1708..1934 CDD:293215 51/279 (18%)
RhoGEF 1935..2105 CDD:279015 40/258 (16%)
PH2_Kalirin_Trio_p63RhoGEF 2109..2243 CDD:270061 31/218 (14%)
PH 2142..2228 CDD:278594 21/168 (13%)
SH3_Kalirin_2 2327..2385 CDD:212787 12/61 (20%)
I-set 2473..2567 CDD:254352 19/93 (20%)
Ig 2490..2564 CDD:143165 18/73 (25%)
FN3 2571..2662 CDD:238020 29/110 (26%)
S_TKc 2686..2940 CDD:214567 78/256 (30%)
STKc_Kalirin_C 2692..2939 CDD:271017 76/249 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11520
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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