DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Unc-89 and KIAA1755

DIOPT Version :9

Sequence 1:	NP_001097440.1	Gene:	Unc-89 / 3346201	FlyBaseID:	FBgn0053519	Length:	4218	Species:	Drosophila melanogaster
Sequence 2:	NP_001025035.1	Gene:	KIAA1755 / 85449	HGNCID:	29372	Length:	1200	Species:	Homo sapiens

Alignment Length:	900	Identity:	180/900 - (20%)
Similarity:	301/900 - (33%)	Gaps:	271/900 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 ELILHLPQRAEAHDPNLSVRPSDVAENYFLSKETKERLQHEQQELLKLEQEAIELY---KK---- 466
            |:::||...    :| |.:|..|    ::|..|.:|    ||...:.::..:::|.   ||
Human    87 EVVVHLAPL----NP-LLLRQGD----FYLQVEPQE----EQSVCIMIKCLSLDLCTVDKKPVPE 138

  Fly   467 --------QQSSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQVKEVTPVKVVSSPPPPK 523
                    |:..::::|..|...:.:..|.|.:.:                        :|.|..
Human   139 PAYPILFTQEWLEAINSDFEGNPLHNCLVASENGI------------------------APVPWT 179

  Fly   524 EITPAKVATPPPQPQVVTS--------PVK--EVAPPPQPRAVASPAKEVTPSQS--------EP 570
            :||..:..  ..:||||.:        |::  :::.|.:....:||..:|.|:||        ..
Human   180 KITSPEFV--DDRPQVVNALCQAWGPLPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGRTYG 242

  Fly   571 VKAPSPIK-------EV--RKEVPPSASHSKEVEALVATEIRESLTE--TRSTVVESGQSSEIRE 624
            .|.|..||       ||  |.:...|.....:..||:... :||..|  :|.....||.:|...|
Human   243 SKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFS-QESRGESPSREAGTSSGCTSGALE 306

  Fly   625 EIVVTEESSLEGKQVVALEREPSP------CSIPKIQVYRP--------VECENPVVTKHKPIE- 674
            ||..|:|:.|..|.:...|....|      |:.|:....||        |..:.|.....:|.:
Human   307 EIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVNLKAPTHNSERPPQG 371

  Fly   675 -----LKDIVGYSESLRDGDTAPAGGSPGRQQGYSANITDHASLTIWNNRLANIAGDRSGANQHL 734
                 |:|.:..:..||.|.:.....|  :.||...|..:...|             |.|..
Human   372 SYMNVLEDALDCASGLRAGVSQEPAAS--KMQGPLGNPENMVQL-------------RPGPR--- 418

  Fly   735 QQSGPPPPPIPPNFTRMPGFFQPLPLIAYETTIEI------------LIVKARPPSPPPPPPPTI 787
            |.|.|...|..|            ...|.||.||:            :...:|..|.|.||.|.:
Human   419 QASSPRLSPASP------------AAAASETKIEVKTKERNGRLPKPMPCPSRNTSSPEPPTPGL 471

  Fly   788 KRVLVHTESLEQKTQNFFEGIYDAASSDTSLRNAKQKIR-SIKSTVLKSKDSTNYAQDTVQKAKA 851
            |...:..:.....|.       :.||..   .|...|:. |:.|.......|...|..|..|...
Human   472 KFSFLRGQRQPSVTP-------EKASLQ---HNGPWKVLCSLYSPKPNRAKSLGKAGTTQTKTSG 526

  Fly   852 RDFLHIFTPPVKKRPIYEIVEEPVNIFELEGDYTESIADDFREPSADFEARGQS--VG--GMDDY 912
                    |.....|   :.||...:.|......|      |.|:.:.|..|..  :|  |:..:
Human   527 --------PATAPSP---LTEEKAALPEASAGSPE------RGPTLEEEPPGPEPRIGALGVKVF 574

  Fly   913 YS-------GYSRASTRRYETKT------------RDYDRGTSYDSTVERSQYGISSRRDRSSVD 958
            .|       |..||........|            .:..:..||..|:.|.:            |
Human   575 RSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPE------------D 627

  Fly   959 K-------VEARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSS----RLQEDRPLR 1012
            |       ::||......|...:..|::|:..|..||...:.|..|.::..:    :::....|:
Human   628 KAKGLAVLIDARRQPPQPGLVSALQATQAQVPASIRAILFLGEKEAALQLQTLPDVQVEVLTSLK 692

  Fly  1013 SVDKPVVVKMLKSVQVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQTAAPMNSYRLD 1077
            ::...|....|.:|...|....|.|           |:...:.|:..||| :.|.::.:.:   .
Human   693 ALSHHVDPSQLPAVLEGPFPYCHTE-----------WVHFFQKLDPFLAD-LHQASSLLQA---S 742

  Fly  1078 IKNCSETD--AGTYTIRAQSASETTTVSAQL--AVGQAPG----------------HDETKTNTE 1122
            |:...:.|  .|     .|.|:...:.|.:|  ||.:.||                ||.::.:..
Human   743 IEEFEKADPPGG-----MQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFS 802

  Fly  1123 P---------AFLVSLKDAEMIENTLFRFMVKIIGDPKPRVKFYKDEKEILETND 1168
            |         ..|.||.|.::  :.|......::|..:.||:..:.|..|.:.:|
Human   803 PDVRSHLAAATALYSLVDEQL--HVLVTASNSLLGKLELRVRLGRLEAAIHQVSD 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Unc-89	NP_001097440.1	RhoGEF	90..260	CDD:238091
		PH_unc89	275..388	CDD:270134
		Atrophin-1	<493..690	CDD:331285	54/245 (22%)
		TonB_N	502..>596	CDD:318287	24/120 (20%)
		I-set	1017..1108	CDD:333254	19/94 (20%)
		I-set	1123..1212	CDD:254352	11/54 (20%)
		I-set	<1236..1299	CDD:333254
		I-set	1313..1403	CDD:254352
		Ig_3	1406..1487	CDD:316449
		I-set	1499..1595	CDD:254352
		I-set	1599..1690	CDD:333254
		I-set	1694..1786	CDD:254352
		I-set	<1836..1903	CDD:333254
		I-set	1922..2005	CDD:333254
		I-set	2018..2108	CDD:333254
		I-set	2113..2214	CDD:333254
		I-set	2220..2302	CDD:254352
		I-set	2318..2408	CDD:254352
		I-set	2415..2506	CDD:254352
		I-set	2519..2608	CDD:254352
		I-set	2615..2696	CDD:254352
		I-set	2717..2805	CDD:254352
		FN3	2834..2925	CDD:238020
		I-set	<2996..3063	CDD:333254
		I-set	3067..3157	CDD:333254
		PK_Unc-89_rpt1	3182..3440	CDD:271011
		I-set	3654..3744	CDD:333254
		FN3	3748..3840	CDD:238020
		STKc_Unc-89_rpt2	3893..4151	CDD:271014
KIAA1755	NP_001025035.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..302		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..372		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..491		26/135 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..568		14/74 (19%)
		CCDC154	675..1043	CDD:317803	37/202 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1056..1200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900