DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Unc-89 and TRIO

DIOPT Version :9

Sequence 1:NP_001097440.1 Gene:Unc-89 / 3346201 FlyBaseID:FBgn0053519 Length:4218 Species:Drosophila melanogaster
Sequence 2:NP_009049.2 Gene:TRIO / 7204 HGNCID:12303 Length:3097 Species:Homo sapiens


Alignment Length:2141 Identity:417/2141 - (19%)
Similarity:700/2141 - (32%) Gaps:777/2141 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 DSGDSPKEGWVPIDIL----------------EFNPTMSSSNGKESGDAEFRKLTILRELVETEE 99
            ||..|.|.  :.:||:                |.|        :|...:..||..|:.||::||:
Human  1251 DSNKSSKS--LQLDIIPASIPGSEVKLRDAAHELN--------EEKRKSARRKEFIMAELIQTEK 1305

  Fly   100 EFSRDLLHVVEKYI----KGIDKPVVPRSVRDNKDIIFCNFLQIAEFHNNVLKEGLKCYSNQPNM 160
            .:.|||...::.|:    .|:::  :|..:.:.:.|||.|..:|.|||||:..:.|:.|...|..
Human  1306 AYVRDLRECMDTYLWEMTSGVEE--IPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPED 1368

  Fly   161 VAKTFLRLERDFDKHVVYCQNEP----LAQDYLGSSPDAKKYFQELSKQLGDDKSLAEHLKLPIQ 221
            |...|:.....|..:|.||:|:|    |..::.||      ||.|:.::.|...|::.:|..|:|
Human  1369 VGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGS------YFDEIQQRHGLANSISSYLIKPVQ 1427

  Fly   222 RINDYQLLFKDFIKYSLSLKENVKDLERALELMLSVPSRAYDNRFLSSIEGCRGNIYKLGRLLLH 286
            ||..||||.|:.:......|..:||   .||:|||||.||.|...||.:||...||...|.|:|.
Human  1428 RITKYQLLLKELLTCCEEGKGEIKD---GLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQ 1489

  Fly   287 AWCNVVDKE---GKAHDRYCFLFKSRILVTKVRKISENRSVFILQ-------------------- 328
            ....|.|.:   .|..:|:.|||:..::.:|..|.|..||.::.:                    
Human  1490 ESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCK 1554

  Fly   329 ------------NIVKLPLCNIELKAD----------EKQIHL--SLKAPEANSFLP-------- 361
                        |.:.|...:||.|.|          |:.|||  :||.|   ..:|        
Human  1555 FALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEP---IHIPKTAPATRQ 1616

  Fly   362 ------IDIKPHGPEAHLTWFNEISSHINQDVTLQEHNADDLKVDASQIASESELILHLPQRAEA 420
                  .|:...|..:.......|:|..:|:.           :|:.:::...||.:.:......
Human  1617 KGRRDGEDLDSQGDGSSQPDTISIASRTSQNT-----------LDSDKLSGGCELTVVIHDFTAC 1670

  Fly   421 HDPNLSVRPSDVAE---------NYFLSKETKER-------------LQHEQQELLKLEQEAIEL 463
            :...|::|.....|         ::.|.:.|...             :.|.:.   .:|.|.|..
Human  1671 NSNELTIRRGQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRS---SMEMEGIFN 1732

  Fly   464 YKKQQSSKSVSSKTESVEITSSQVKSSSEVRKVVSPPPPPQAQVKEVTPVKV-VSSPPPPKEITP 527
            :|   .|.||||...|                       |.|.|..:.|..: ..|.|.||.  |
Human  1733 HK---DSLSVSSNDAS-----------------------PPASVASLQPHMIGAQSSPGPKR--P 1769

  Fly   528 AKVATPPPQPQVVTSPVKEVAPPPQPRAVASPAKEVTPSQSEPVKAPSPIKEVRKEVPPSASHSK 592
            .....     :.:||||:.::..                     ||...:|::      :..|.|
Human  1770 GNTLR-----KWLTSPVRRLSSG---------------------KADGHVKKL------AHKHKK 1802

  Fly   593 EVEALVATEIRESLTETRSTVVESGQSSEIREEIVVTEESSLEGKQVVALEREPSPCSIPKIQVY 657
                  :.|:|:|        .::|...:..:.....::.::|       ||             
Human  1803 ------SREVRKS--------ADAGSQKDSDDSAATPQDETVE-------ER------------- 1833

  Fly   658 RPVECENPVVTKHKPIELKDIVGYSESLRDGDTAPAGGSPGRQQGYSANITDHASLTIWNNRLAN 722
                                  |.:|.|..| |.....|.|.|.                     
Human  1834 ----------------------GRNEGLSSG-TLSKSSSSGMQS--------------------- 1854

  Fly   723 IAGDRSGANQHLQQSGPPPPPIPPNFTRMPGFFQPLPLIAYET-----TIEILIVKARPPSPPPP 782
             .|:..|      :.|....|:||     |...|...|:..::     :..:|:   ||.|...|
Human  1855 -CGEEEG------EEGADAVPLPP-----PMAIQQHSLLQPDSQDDKASSRLLV---RPTSSETP 1904

  Fly   783 PP----PTIKRVLVHTESLEQKTQNFFEGIYDAAS-----SDTSLRNAKQKIRSI---KSTVLKS 835
            ..    ..|:.::....:||.:..:......|::|     ||.||.::...|..:   ||:.||.
Human  1905 SAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKR 1969

  Fly   836 KDSTNYA-QDTVQKAKARDFLHIFTPPVKKRPIYEIVEEPVNIFELEGDYTESIADDFREPSADF 899
            :   :|. |:.|:  ..||::         |.:..:||..:.:.:.:|     :.||.       
Human  1970 R---HYVLQELVE--TERDYV---------RDLGYVVEGYMALMKEDG-----VPDDM------- 2008

  Fly   900 EARGQS---VGGMDDYYSGYSRASTRRYETKTRDYDRGTSYDSTVERSQYGISSRRDRSSVDKVE 961
              :|:.   .|.:...|..:            ||:..|     .:|:            .::..|
Human  2009 --KGKDKIVFGNIHQIYDWH------------RDFFLG-----ELEK------------CLEDPE 2042

  Fly   962 ARSSLLATGRTESRAASRAESRAESRASYSVAESRAGIRSSSRLQEDRPLRSVDKPVVVKMLKSV 1026
            ...||..          :.|.|.....:|.               :::|                
Human  2043 KLGSLFV----------KHERRLHMYIAYC---------------QNKP---------------- 2066

  Fly  1027 QVEPGETAHFEIQFKDQPGLVTWLKDNKPLEDRLADRITQT---AAPMN---SYRLDIKNCSE-- 1083
                 ::.|...::.|     |:.:|   |:.||..|:..|   ..|:.   .|:|.:|:..:  
Human  2067 -----KSEHIVSEYID-----TFFED---LKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYS 2118

  Fly  1084 TDAGTYTIRAQSASETTTV-----SAQLAVGQAPGHD-----ETKTNTEPAFLVSLKDAEMI--- 1135
            ..|...|...:.|.|...:     :..:.||:..|.|     :.|...:..|||:.:||.::   
Human  2119 KKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVAQGKLLLQDTFLVTDQDAGLLPRC 2183

  Fly  1136 -ENTLFRF-MVKIIGDPKPRVK-------FYKDEKEI----LE---------------TNDRI-- 1170
             |..:|.| .:.|..:|..:.|       .:|:..::    ||               |.|.:  
Human  2184 RERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVENDPCKFALTSRTGDVVET 2248

  Fly  1171 -------------------QIIRD-KDYLGFYELVIADVQKT----------------------- 1192
                               ||:.: :::|......| :.|:.                       
Human  2249 FILHSSSPSVRQTWIHEINQILENQRNFLNALTSPI-EYQRNHSGGGGGGGSGGSGGGGGSGGGG 2312

  Fly  1193 --------DAGTYSC---------------------------KATNKHGEAN-CEAIATTVEDKN 1221
                    ..|..||                           .|.:...||: ....:|......
Human  2313 APSGGSGHSGGPSSCGGAPSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLP 2377

  Fly  1222 PFGAL--SGQILPAGEKPVFQWKRNGEEFDPEERFKVL----------FGEDEDSLALVFQHVKP 1274
            |.||.  :|...|:...|....:.:..|.:|..:.|||          .|...|:.|      |.
Human  2378 PPGAAPEAGPSAPSRRPPGADAEGSEREAEPIPKMKVLESPRKGAANASGSSPDAPA------KD 2436

  Fly  1275 EDAGIYTCVAQTSTGNISCSAELSVQGAIQTLNREPEKPTLVIEHREANASIGGSAILELQCKGF 1339
            ..|.:.|..........:......:..|:.:|.:||..|:..::.       |||....:.....
Human  2437 ARASLGTLPLGKPRAGAASPLNSPLSSAVPSLGKEPFPPSSPLQK-------GGSFWSSIPASPA 2494

  Fly  1340 PKP-AVQWKHDGEVIQ-VDDRHKFMYEDEESMSLV--------------------IKNVDTV--- 1379
            .:| :..:..|.:.:| ...||....:|.:.||..                    ..|:.|:   
Human  2495 SRPGSFTFPGDSDSLQRQTPRHAAPGKDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVT 2559

  Fly  1380 ---------DAGVYTIEAINELGQDESSINLVVKAPPKIKKITDITCSAGETIKMEIEVEGFPQP 1435
                     :..||..|.:..|..::.::.||.:|      .|| .|.|.|.     .:.||   
Human  2560 HDYTAVKEDEINVYQGEVVQILASNQQNMFLVFRA------ATD-QCPAAEG-----WIPGF--- 2609

  Fly  1436 TVQVTNNGKDVTAES---NVKISSS-SIGKSLEKVVVEVKEIKLSQAGNYSIKATNDLSQTSEYW 1496
               |..:...|..|:   .:|.|:| .....|.|     |..|..:.|....|..|...::.|  
Human  2610 ---VLGHTSAVIVENPDGTLKKSTSWHTALRLRK-----KSEKKDKDGKREGKLENGYRKSRE-- 2664

  Fly  1497 SCTVKSKPVIVKNFESEYIHG---------------EKENVQMTVRIDAYPEAKLTWYHDETEIK 1546
               ..|..|.||.....||:.               ..|.|.:..|:...|:|.:||...|....
Human  2665 ---GLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETGETVVLRCRVCGRPKASITWKGPEHNTL 2726

  Fly  1547 ITDSKYTVS-SDGNAYTLKITGATRVDAGKYTVKATNEHGSATSSTQLLI--------------- 1595
            ..|..|::| ||....||||.|.|..|.|.||..|.|:.|||:||..|.:               
Human  2727 NNDGHYSISYSDLGEATLKIVGVTTEDDGIYTCIAVNDMGSASSSASLRVLGPGMDGIMVTWKDN 2791

  Fly  1596 --------------------KC---------APEFTHK--LKNITVAEGDSNVE-----LVVG-V 1623
                                ||         |.:|.:|  :|...|......::     |:|| :
Human  2792 FDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLL 2856

  Fly  1624 DAYPRPHAKWYIDGIEIDEKRN------DFRHVEEGNDFKLIMNQVATNMQGNYTCKIMNDYGKL 1682
            |.:..|.:  ||..:|:.::..      .:..:.||. .:..:.:|...::..:.|:|.:     
Human  2857 DTFETPTS--YILVLEMADQGRLLDCVVRWGSLTEGK-IRAHLGEVLEAVRYLHNCRIAH----- 2913

  Fly  1683 EDNCVVTVNCKPKVKRGLKNVEVQEGKSFTLEVEVYSEPEAKIKWFKDGHEIYEDARIKISRDTQ 1747
                   ::.||      :|:.|.|.         .::|..|:..|.|.              .|
Human  2914 -------LDLKP------ENILVDES---------LAKPTIKLADFGDA--------------VQ 2942

  Fly  1748 RIENYYLTLNLARTEDAGTYEMKATNFIGETTSTCKVAVLTSEALS-----LEQTVTKTLI 1803
            ....||:...|...|.|.. |:...|.:..|:.|..|.|||...||     |:.:|.:|.:
Human  2943 LNTTYYIHQLLGNPEFAAP-EIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCL 3002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Unc-89NP_001097440.1 RhoGEF 90..260 CDD:238091 60/177 (34%)
PH_unc89 275..388 CDD:270134 36/173 (21%)
Atrophin-1 <493..690 CDD:331285 29/197 (15%)
TonB_N 502..>596 CDD:318287 18/94 (19%)
I-set 1017..1108 CDD:333254 17/103 (17%)
I-set 1123..1212 CDD:254352 27/200 (14%)
I-set <1236..1299 CDD:333254 12/72 (17%)
I-set 1313..1403 CDD:254352 19/123 (15%)
Ig_3 1406..1487 CDD:316449 19/84 (23%)
I-set 1499..1595 CDD:254352 37/111 (33%)
I-set 1599..1690 CDD:333254 17/104 (16%)
I-set 1694..1786 CDD:254352 19/91 (21%)
I-set <1836..1903 CDD:333254
I-set 1922..2005 CDD:333254
I-set 2018..2108 CDD:333254
I-set 2113..2214 CDD:333254
I-set 2220..2302 CDD:254352
I-set 2318..2408 CDD:254352
I-set 2415..2506 CDD:254352
I-set 2519..2608 CDD:254352
I-set 2615..2696 CDD:254352
I-set 2717..2805 CDD:254352
FN3 2834..2925 CDD:238020
I-set <2996..3063 CDD:333254
I-set 3067..3157 CDD:333254
PK_Unc-89_rpt1 3182..3440 CDD:271011
I-set 3654..3744 CDD:333254
FN3 3748..3840 CDD:238020
STKc_Unc-89_rpt2 3893..4151 CDD:271014
TRIONP_009049.2 SEC14 69..204 CDD:214706
SPEC 230..445 CDD:238103
Spectrin 1 311..418
SPEC 341..566 CDD:238103
Spectrin 2 538..644
SPEC 567..783 CDD:238103
SPEC 787..1014 CDD:238103
Spectrin 3 878..984
SPEC 908..1137 CDD:238103
Spectrin 4 1109..1216
SPEC 1143..1243 CDD:197544
RhoGEF 1295..1465 CDD:238091 61/180 (34%)
PH1_Kalirin_Trio_like 1472..1594 CDD:270060 26/121 (21%)
PH 1505..1590 CDD:278594 15/84 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1601..1650 9/62 (15%)
SH3_Kalirin_1 1659..1718 CDD:212786 7/58 (12%)
SH3-RhoG_link 1715..1972 CDD:293215 72/415 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1779..1906 37/246 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1927..1965 8/37 (22%)
RhoGEF 1970..2143 CDD:238091 42/283 (15%)
PH2_Kalirin_Trio_p63RhoGEF 2148..2286 CDD:270061 25/138 (18%)
PH 2175..2271 CDD:278594 15/95 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2287..2552 41/277 (15%)
SH3_Kalirin_2 2555..2613 CDD:212787 16/75 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2639..2660 6/25 (24%)
I-set 2685..2776 CDD:254352 31/90 (34%)
Ig 2699..2776 CDD:299845 31/76 (41%)
STKc_Trio_C 2788..3050 CDD:271015 48/260 (18%)
S_TKc 2796..3050 CDD:214567 48/252 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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